Abstract: In representative embodiments, architectures to improve security through use of an anomaly score are disclosed. A set of cryptographic key material is used to create a model based on a dimensionality reduction and a density estimation that captures the expected behavior of the set of cryptographic key material. An anomaly score for presented cryptographic key material is calculated based on the model. The anomaly score represents the divergence from expectations for the presented cryptographic key material. The anomaly score can be used by a relying system to determine whether to trust the presented cryptographic key material. In this way, cryptographic key material that is valid can be tested to determine whether the cryptographic key material should be trusted even though it is valid.

Abstract: A vehicle determines a traction value for a surface of a road segment, and associates the traction value with a location of the surface. The vehicle stores the traction value and location as part of a traction map.

Abstract: A method for operating a pallet positioning station for positioning a pallet to be impacted by a pallet impact station is provided. The pallet positioning station includes a frame adjacent the pallet impact station, a pallet lift assembly carried by the frame that includes a lift grate moveable between a retracted position and an extended position, and a pallet push arm assembly carried by the frame that includes a pallet push arm movable between a retracted position and a pallet positioning position. The method includes moving the pallet push arm and the lift grate to the retracted positions to receive the pallet for positioning, moving the lift grate to the extended position when the pallet is to be positioned for impact by the pallet impact station, and moving the pallet push arm to the pallet positioning position to position the pallet towards the pallet impact station until the pallet is aligned with an impact reference plane.

Abstract: A pallet positioning station for positioning a pallet to be impacted by a pallet impact station includes a frame, and a pallet lift assembly carried by the frame. The pallet lift assembly includes a lift grate moveable between a retracted position and an extended position. A pallet push arm assembly is carried by the frame and includes a pallet push arm movable between a retracted position and a pallet positioning position. A controller is configured to move the pallet push arm and the lift grate to the retracted positions to receive the pallet for positioning, and move the lift grate to the extended position when the pallet is to be positioned for impact by the pallet impact station. The controller is further configured to move the pallet push arm to the pallet positioning position to move the pallet towards the pallet impact station until the pallet is aligned with an impact reference plane.

Abstract: The present invention relates to exosomes, loaded with genetic material and methods of producing them and to the use of such exosomes for delivering genetic material in vivo, in particular the use of such exosomes in methods of gene therapy or gene silencing.

Abstract: Techniques are described herein for normalizing the recipient style of electronic messages while preserving the discernible intent of the sender. Given an electronic message or series of messages with varying visual styles applied to message text and other content, the electronic message may be transformed with a normalized and consistent formatting style that is more pleasing to the recipient, while preserving the sender's discernible intent in stylizing the message.

Abstract: In representative embodiments, systems and methods to calculate the likelihood that presented cryptographic key material is untrustworthy are disclosed. A predictive model based on a debasing condition and a dataset is created by evaluating the dataset relative to the debasing condition. For example, if certificate revocation is selected as the debasing condition, the dataset is analyzed to produce a predictive model that determines the likelihood that a presented certificate is untrustworthy based on similarity to already revoked certificates. The predictive model can include a supervised learning model like a logistic regression model or a deep neural network model. The system can be used in conjunction with existing security infrastructures or can be used as a separate infrastructure. Based on the likelihood score calculated by the model, a relying system can reject the cryptographic key material, accept the cryptographic key material or take other further action.

Abstract: The present invention relates to peptides, in particular cell penetrating peptides, of 40 amino acid residues or less comprising at least one directly glycosylated amino residue and one or more arginine rich arm domains, and to conjugates of such cell penetrating peptides with a therapeutic molecule. The present invention further relates to the use of the peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders of the central nervous system. page.

Abstract: The application discloses integrated air suspension and platform lifting systems that utilize an existing air supply for lifting one or more platforms installed in a trailer or hauling vehicle. An apparatus for lifting a rear gate or platform of a trailer or a hauling vehicle is disclosed that includes an actuating mechanism operable to pivot the platform between a lowered position (e.g., where the end of the platform is in contact with the ground) and a range of raised positions (e.g., where the platform is raised to meet an elevated platform such as a loading dock). The lifting mechanisms for raising and lowering the platform(s) may utilize a pressurized gas supply from a compressor. In some embodiments, the lifting mechanism may be supplied with pressurized air from a compressor of a brake system of a tractor. In some embodiments a separate locking mechanism is provided to hold the platform in place after the lifting system has moved it into a desired position.

Abstract: A reconfigurable pallet/dolly platform includes a top deck that includes a product support surface and an opposing underside. The underside includes pallet support leg attachment areas for receiving pallet support legs when configured as a pallet, and dolly wheel attachment areas for receiving dolly wheels when configured as a dolly. The product support surface includes pallet support leg receiving areas aligned with the pallet support leg attachment areas and configured to engage the pallet support legs from an identical platform stacked thereon when configured as a pallet. The product support surface also includes dolly wheel receiving areas aligned with the dolly wheel wells and configured to engage the dolly wheels from an identical platform stacked thereon when configured as a dolly. Each dolly wheel receiving area partially overlaps with one of the pallet support leg receiving areas.

Abstract: Systems and methods are provided for controlling a HVAC system of a vehicle. An exemplary method may comprise: collecting data describing environmental measurements and one or more states of the HVAC system; predicting one or more target values by inputting the collected data into one or more inference models that include a personal inference model, wherein the personal inference model is used to predict a personal target value for the vehicle or a user of the vehicle; and outputting the one or more target values including the personal target value for the vehicle or the user of the vehicle to control the HVAC system of the vehicle.

Abstract: In representative embodiments, systems and methods to calculate the likelihood that presented cryptographic key material is untrustworthy are disclosed. A predictive model based on a debasing condition and a dataset is created by evaluating the dataset relative to the debasing condition. For example, if certificate revocation is selected as the debasing condition, the dataset is analyzed to produce a predictive model that determines the likelihood that a presented certificate is untrustworthy based on similarity to already revoked certificates. The predictive model can include a supervised learning model like a logistic regression model or a deep neural network model. The system can be used in conjunction with existing security infrastructures or can be used as a separate infrastructure. Based on the likelihood score calculated by the model, a relying system can reject the cryptographic key material, accept the cryptographic key material or take other further action.

Abstract: A reconfigurable pallet/dolly platform includes a top deck that includes a product support surface and an opposing underside. The underside includes pallet support leg attachment areas for receiving pallet support legs when configured as a pallet, and dolly wheel attachment areas for receiving dolly wheels when configured as a dolly. The product support surface includes pallet support leg receiving areas aligned with the pallet support leg attachment areas and configured to engage the pallet support legs from an identical platform stacked thereon when configured as a pallet. The product support surface also includes dolly wheel receiving areas aligned with the dolly wheel wells and configured to engage the dolly wheels from an identical platform stacked thereon when configured as a dolly.

Abstract: The present invention relates to the combined use of antisense oligonucleotides and viral vectors for the treatment of Duchenne muscular dystrophy.

Abstract: A pallet impact station includes a frame, at least one pendulum swing arm rotatably coupled to the frame, a carriage assembly carried by the at least one pendulum swing arm for impacting a pallet, and a latching mechanism extending between the frame and the at least one pendulum swing arm. The latching mechanism disengages the at least one pendulum swing arm at a raised position so that the carriage assembly impacts the pallet. A controller operates the latching mechanism to disengage the at least one pendulum swing arm.

Abstract: A pallet tester includes a pallet positioning station for positioning a pallet on a conveyor, and a pallet impact station adjacent the conveyor and aligned with the pallet positioning station. The pallet positioning station includes a pallet push arm movable between a retracted position and a pallet positioning position. The pallet impact station includes a carriage assembly to impact the pallet, and a latching mechanism coupled to the carriage assembly. A controller moves the pallet push arm to the retracted position to receive the pallet for positioning, and moves the pallet push arm to the pallet positioning position to move the pallet towards the pallet impact station until an impact side of the pallet is aligned with an impact reference plane.

Abstract: A pallet impact station includes a frame, at least one pendulum swing arm rotatably coupled to the frame, and a carriage assembly carried by the at least one pendulum swing arm. A latching mechanism extends between the frame and the at least one pendulum swing arm, and engages the at least one pendulum swing arm when the carriage assembly is in a lowered position, raises the carriage assembly to a raised positon, and disengages the at least one pendulum swing arm at the raised positon so that the carriage assembly strikes a pallet. A sensor generates a signal corresponding to how high the carriage assembly is raised. A controller operates the latching mechanism, including disengaging the at least one pendulum swing arm when a height of the carriage assembly corresponds to a desired release height so that a predetermined impact force strikes the pallet.

Abstract: A pallet positioning station for positioning a pallet to be impacted by a pallet impact station includes a frame, and a pallet lift assembly carried by the frame. The pallet lift assembly includes a lift grate moveable between a retracted position and an extended position. A pallet push arm assembly is carried by the frame and includes a pallet push arm movable between a retracted position and a pallet positioning position. A controller is configured to move the pallet push arm and the lift grate to the retracted positions to receive the pallet for positioning, and move the lift grate to the extended position when the pallet is to be positioned for impact by the pallet impact station. The controller is further configured to move the pallet push arm to the pallet positioning position to move the pallet towards the pallet impact station until the pallet is aligned with an impact reference plane.

Abstract: A method for operating a pallet positioning station for positioning a pallet to be impacted by a pallet impact station is provided. The pallet positioning station includes a frame adjacent the pallet impact station, a pallet lift assembly carried by the frame that includes a lift grate moveable between a retracted position and an extended position, and a pallet push arm assembly carried by the frame that includes a pallet push arm movable between a retracted position and a pallet positioning position. The method includes moving the pallet push arm and the lift grate to the retracted positions to receive the pallet for positioning, moving the lift grate to the extended position when the pallet is to be positioned for impact by the pallet impact station, and moving the pallet push arm to the pallet positioning position to position the pallet towards the pallet impact station until the pallet is aligned with an impact reference plane.

Abstract: The present invention relates to exosomes, loaded with genetic material and methods of producing them and to the use of such exosomes for delivering genetic material in vivo, in particular the use of such exosomes in methods of gene therapy or gene silencing.