Abstract: This invention relates to compounds of the formula wherein one of R5, R6 and R7 is and X1, X2, Y1 to Y4, R1 to R13 and m and n are defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists.

Abstract: This invention relates to compounds of the formula wherein one of R6, R7 or R8 is and all enantiomers and pharmaceutically acceptable salts and/or esters thereof as well as pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR? and/or PPAR? agonists.

Abstract: A method and apparatus for the selection of oral care chemistries by a consumer from a plurality of available options. An oral care selection advisor first requests information from a consumer regarding their oral care preferences. The oral care selection advisor then selects a classification of chemistries from among at least two available classifications corresponding to those oral care preferences. The information is then displayed from the oral care selection advisor identifying at least one chemistry within the selected classification, allowing the consumer to identify the chemistries corresponding to the consumer's oral care preferences.

Abstract: A brushing system including a multiple cartridge dispensing system which dispenses the treatment material either directly onto brush bristles, or through the brush to the bristles. A multiplicity of materials may be provided to the cartridges for use in brushing. In addition to use in dental care, the system finds utility in hair coloring, spot laundry cleaning, skin and nail care, and polishing, as well as numerous others.

Abstract: A brushing system including a multiple cartridge dispensing system which dispenses the treatment material either directly onto brush bristles, or through the brush to the bristles. A multiplicity of materials may be provided to the cartridges for use in brushing. In addition to use in dental care, the system finds utility in hair coloring, spot laundry cleaning, skin and nail care, and polishing, as well as numerous others.

Abstract: A multiple dose delivery device for delivering a medicament into an oral cavity of a patient is provided. The device includes a sachet pack including a plurality of unit doses of a medicament enclosed between a first strip and a second strip. The device further includes a sachet advance mechanism and a mouthpiece. Upon actuation by a user, the sachet advance mechanism, which is engaged with the sachet pack, separates the first strip from the second strip to release one of the plurality of the unit doses from the sachet pack. The mouthpiece includes an opening, and each released unit dose passes through the opening.

Abstract: A support arm assembly for assisting in the performance of cardiac surgery has an articulated arm movable axially of a support base and rotatable relative to the support base. A distal end of the articulated arm receives a contact member and the contact member is moveable relative to the distal end. A surgeon may configure the support arm assembly to contact a desired portion of a heart and fix the articulated arm, its axial position, its rotated position and the orientation of the contact member with a single control.

Abstract: An interface for a peer-to-peer communications network, such as a token ring network, uses a master-slave serial communications controller and an adapter to enable the interface to operate in a peer-to-peer mode on the network.

Abstract: An endoprosthetic knee joint device with separate pairs of femoral and tibial condylar runner and track components is improved in respect of bone cement fixation surfaces, mutually articulatory bearing surfaces, and securement location relative to each other and the relevant bones. The femoral components have L-shaped fixation surfaces defining a slightly obtuse angle, and the tibial component fixation surfaces are tapered. The femoral component bearing surfaces have longitudinal convex curvature of higher and lower order over respective end portions, the tibial component bearing surface has longitudinal concave curvature of lowest order, and these bearing surfaces have complementary lateral curvatures of highest order. All components have recesses at one end to engage a jig assembly which connects with the femur in predetermined relationship and locates the components relative to the natural condyles.

Abstract: The valve body of a prosthetic heart valve of annular base-cage-ball or disc type has its annular base member circumferentially grooved around its outer periphery and its cage formed with arcuate members held in such grooving. Preferably the arcuate members are formed with the other cage members from a single length of material to a closed loop configuration with four axially directed cage portions joined remotely from the base and interconnected by two diagonally opposed quadrant portions seated in the base groove. One of the base groove side walls is notched to receive the cage portions and this can provide a snap fit or the quandrants can be tied by threading in the groove.