Abstract: Methods, kits, and systems for fixation of RNA permitting its detection in intact tissue, such as, large volume of mammalian tissue are disclosed. The methods, kits, and systems utilize carbodiimide-based chemistry to stably retain RNAs in tissue clarified using CLARITY. Also provided herein are methods, kits, and systems for detection of RNAs in clarified tissue.

Abstract: The present invention relates to methods of improving the environment within a poultry farming facility including reducing ammonia production in a poultry facility, inhibiting urease enzymes in poultry litter, reducing levels of pathogenic bacteria in poultry litter, improving productivity of poultry farms, reducing or preventing pododermatitis in poultry reared in mass production poultry facilities and controlling pests in poultry litter. Compositions, suitable for use in such methods, comprising at least one microorganism of the genus Bacillus and at least one biosurfactant wherein the biosurfactant is present in an amount of 2 mg/L to 7000 mg/L are also described.

Abstract: The present disclosure is directed to a continuous process for preparing cellulose reactive adducts of polyvinylamide.

Abstract: A method for estimating a boundary for a future location of a moving object includes: receiving location information about two previous locations of the moving object represented by a first and a second elliptical error probabilities (EEPs); representing each of the EEPs as a conic section via an implicit quadratic equation; defining four tangent lines from the implicit quadratic equation, each tangent line being tangent to both of the EEPs; determining two transverse tangent lines from the four tangent lines; forming a cone in a direction from the first EEP to the second EEP from the two transverse tangent lines; and estimating the boundary of the future location of the moving object as a first side of the cone formed by a first transverse tangent line and a second side of the cone formed by a second transverse tangent line, of the two transverse tangent lines.

Abstract: A method for estimating a boundary for a future location of a moving object includes: receiving location information about two previous locations of the moving object represented by a first and a second elliptical error probabilities (EEPs); representing each of the EEPs as a conic section via an implicit quadratic equation; defining four tangent lines from the implicit quadratic equation, each tangent line being tangent to both of the EEPs; determining two transverse tangent lines from the four tangent lines; forming a cone in a direction from the first EEP to the second EEP from the two transverse tangent lines; and estimating the boundary of the future location of the moving object as a first side of the cone formed by a first transverse tangent line and a second side of the cone formed by a second transverse tangent line, of the two transverse tangent lines.

Abstract: The present invention relates to compounds of the formula wherein A1, A2, A3 and R1 to R8 are defined in the description, and to pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical compositions containing them and their use as medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as particularly dyslipidemia, atherosclerosis and cardiovascular diseases.

Abstract: The present invention relates to methods of improving the environment within a poultry farming facility including reducing ammonia production in a poultry facility, inhibiting urease enzymes in poultry litter, reducing levels of pathogenic bacteria in poultry litter, improving productivity of poultry farms, reducing or preventing pododermatitis in poultry reared in mass production poultry facilities and controlling pests in poultry litter. Compositions, suitable for use in such methods, comprising at least one microorganism of the genus Bacillus and at least one biosurfactant wherein the biosurfactant is present in an amount of 2 mg/L to 7000 mg/L are also described.

Abstract: The present invention relates to a method of producing biosurfactants, such as surfactin, comprising culturing at least one biosurfactant-producing microbe in a liquid culture medium comprising vinasse as a carbon source. Methods of using the crude biosurfactant containing culture broth in tertiary oil recovery and as antibacterial compositions in tertiary oil recovery are also described. Methods of using the culture broth residue after isolation of the biosurfactants as fertilizer and compositions for this use are also described.

Abstract: The present invention relates to compounds of the formula wherein A1, A2, A3 and R1 to R8 are defined in the description, and to pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical compositions containing them and their use as medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as particularly dyslipidemia, atherosclerosis and cardiovascular diseases.

Abstract: The present invention relates to compounds of the formula wherein A1, A2, A3 and R1 to R8 are defined in the description, and to pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical compositions containing them and their use as medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as particularly dyslipidemia, atherosclerosis and cardiovascular diseases.