Patents by Inventor Matthias Grauert

Matthias Grauert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
    Patent number: 7371753
    Abstract: Disclosed are new dihydropteridinones of general formula (I) wherein the groups R1 to R5, Ra to Rc, W, Q1 and Q2 have the meanings given in the claims and specification, the isomers thereof and the use thereof for preparing a pharmaceutical composition for the treatment of diseases characterised by excessive or abnormal cell proliferation.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: May 13, 2008
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Heinz Stadtmueller, Harald Engelhardt, Andreas Schoop, Martin Steegmaier, Matthias Hoffmann, Matthias Grauert
  • Dihydropteridione Intermediate Compounds
    Publication number: 20080108812
    Abstract: Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
    Type: Application
    Filed: December 18, 2007
    Publication date: May 8, 2008
    Inventors: Matthias Grauert, Matthias Hoffmann, Christian Eickmeier
  • Dihydropteridione derivatives, process for their manufacture and their use as medicament
    Patent number: 7332491
    Abstract: Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
    Type: Grant
    Filed: August 24, 2005
    Date of Patent: February 19, 2008
    Assignee: Boehringer Ingelheim International, GmbH
    Inventors: Matthias Grauert, Matthias Hoffmann, Martin Steegmaier, Christian Eickmeier, Gisela Schnapp, Norbert Redemann, Flavio Solca, Jens Juergen Quant
  • Thiazolyl-Dihydro-Indazole
    Publication number: 20070270401
    Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R5 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
    Type: Application
    Filed: April 5, 2007
    Publication date: November 22, 2007
    Inventors: Steffen STEURER, Bodo BETZEMEIER, Darryl MCCONNELL, Thomas GERSTBERGER, Matthias GRAUERT, Matthias HOFFMANN, Maria IMPAGNATIELLO, Lars van der VEEN, Ulrike WEYER-CZERNILOFSKY
  • THIAZOLYL-DIHYDRO-INDAZOLE
    Publication number: 20070259855
    Abstract: Disclosed are compounds of general formula (I), wherein the groups R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-indazoles and the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: March 23, 2007
    Publication date: November 8, 2007
    Inventors: Udo Maier, Matthias Grauert, Matthias Hoffmann, Christoph Hoenke, Anne Joergensen, Alexander Pautsch, Trixi Brandl, Steffen Breitfelder, Stefan Scheuerer, Klaus Erb, Michael Pieper, Ingo Pragst
  • THIAZOLYL-DIHYDRO-QUINAZOLINE
    Publication number: 20070244104
    Abstract: Disclosed are thiazolyl-dihydro-quinazolines of general formula (I) wherein the groups R1 to R4 have the meanings given in the claims and specification, the isomers thereof, and processes for preparing these compounds and their use as pharmaceutical compositions.
    Type: Application
    Filed: March 23, 2007
    Publication date: October 18, 2007
    Inventors: Trixi Brandl, Udo Maier, Matthias Hoffmann, Stefan Scheuerer, Anne Joergensen, Alexander Pautsch, Steffen Breitfelder, Matthias Grauert, Christoph Hoenke, Klaus Erb, Michael Pieper, Ingo Pragst
  • THIAZOLYL-DIHYDRO-CHINAZOLINE
    Publication number: 20070238746
    Abstract: Disclosed are compounds of general formula (I), wherein the groups A, R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-quinazolines and the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: March 23, 2007
    Publication date: October 11, 2007
    Inventors: Trixi Brandl, Udo Maier, Christoph Hoenke, Anne Joergensen, Alexander Pautsch, Steffen Breitfelder, Matthias Grauert, Matthias Hoffmann, Stefan Scheuerer, Klaus Erb, Michael Pieper, Ingo Pragst
  • THIAZOLYL-DIHYDRO-INDAZOLE
    Publication number: 20070238718
    Abstract: The present invention relates to new thiazolyl-dihydro-indazoles of general formula (I) wherein the groups R1, R2 and R3 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-indazoles and the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: March 23, 2007
    Publication date: October 11, 2007
    Inventors: Matthias GRAUERT, Udo Maier, Matthias Hoffmann, Stefan Scheuerer, Anne Joergensen, Alexander Pautsch, Trixi Brandl, Christoph Hoenke, Steffen Breitfelder, Klaus Erb, Michael Pieper, Ingo Pragst
  • THIAZOLYL-DIHYDRO-CYCLOPENTAPYRAZOLE
    Publication number: 20070238730
    Abstract: Disclosed are compounds of general formula (I), wherein the groups R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-cyclopentapyrazoles and the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: March 23, 2007
    Publication date: October 11, 2007
    Inventors: Steffen Breitfelder, Udo Maier, Christoph Hoenke, Anne Joergensen, Alexander Pautsch, Trixi Brandl, Matthias Grauert, Matthias Hoffmann, Stefan Scheuerer, Klaus Erb, Michael Pieper, Ingo Pragst
  • SPECIFIC SALT, ANHYDROUS AND CRYSTALLINE FORM OF A DIHYDROPTERIDIONE DERIVATIVE
    Publication number: 20070203146
    Abstract: The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.
    Type: Application
    Filed: January 30, 2007
    Publication date: August 30, 2007
    Inventors: Guenter Linz, Peter Sieger, Matthias Grauert, Rolf Schmid
  • Pyrimidines as PLK inhibitors
    Patent number: 7241769
    Abstract: The present invention comprises compounds of general formula (1) wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: July 10, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Heinz Stadtmueller, Harald Engelhardt, Ulrich Reiser, Stephan Karl Zahn, Rudolf Hauptmann, Martin Steegmaier, Ulrich Guertler, Matthias Hoffmann, Matthias Grauert
  • 6-formyl-tetrahydropteridines, process for their manufacture and use thereof as medicaments
    Patent number: 7241889
    Abstract: Disclosed are 6-formyl-tetrahydropteridines of the formula (I) wherein the groups R1 to R6 have the meanings given in the claims and specification, the isomers thereof, methods of preparing these 6-formyl-tetrahydropteridines and their use as medicaments.
    Type: Grant
    Filed: July 12, 2005
    Date of Patent: July 10, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Hoffmann, Matthias Grauert, Martin Steegmaier, Flavio Solca
  • Dihydropteridinones in the treatment of respiratory diseases
    Publication number: 20070043055
    Abstract: The present invention relates to the use of dihydropteridinones of formula 1 wherein the groups X, R1, R2, R3, R4, R5, R6 and R7 have the meanings given in the claims and specification, for the preparation of a medicament for the treatment of respiratory diseases.
    Type: Application
    Filed: July 18, 2006
    Publication date: February 22, 2007
    Inventors: Udo Maier, Frank Kalkbrenner, Frank Buettner, Steffen Breitfelder, Matthias Grauert, Matthias Hoffmann
  • Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
    Patent number: 7094788
    Abstract: The present invention relates to new compounds of general formula 1 wherein X? and the groups A, B, R, R1, R2, R3, R3?, R4, R4?, Rx and Rx? may have the meanings given in the claims and in the specification, processes for preparing them and their use as pharmaceutical compositions.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: August 22, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Matthias Grauert, Michael P. Pieper, Gerald Pohl, Georg Speck, Steffen Breitfelder
  • Medicaments for the Treatment or Prevention of Fibrotic Diseases
    Publication number: 20060154939
    Abstract: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.
    Type: Application
    Filed: December 20, 2005
    Publication date: July 13, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: John Park, Nveed Chaudhary, Thorsten Lehmann-Lintz, Armin Heckel, Gerald Roth, Joerg Kley, Trixi Brandl, Georg Dahmann, Matthias Grauert
  • Medicaments for the Treatment or Prevention of Fibrotic Diseases
    Publication number: 20060142373
    Abstract: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.
    Type: Application
    Filed: December 20, 2005
    Publication date: June 29, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: John Park, Gerald Roth, Armin Heckel, Nveed Chaudhary, Trixi Brandl, Georg Dahmann, Matthias Grauert
  • PI3-kinases
    Publication number: 20060106013
    Abstract: New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastrointestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.
    Type: Application
    Filed: October 5, 2005
    Publication date: May 18, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Steffen Breitfelder, Udo Maier, Trixi Brandl, Christoph Hoenke, Matthias Grauert, Alexander Pautsch, Matthias Hoffmann, Frank Kalkbrenner, Anne Joergensen, Gerhard Schaenzle, Stefan Peters, Frank Buettner, Eckhart Bauer
  • Thiazolyl-dihydro-indazole
    Publication number: 20060100254
    Abstract: The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in Claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
    Type: Application
    Filed: October 5, 2005
    Publication date: May 11, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Bodo Betzemeier, Trixi Brandl, Steffen Breitfelder, Ralph Brueckner, Thomas Gerstberger, Michael Gmachl, Matthias Grauert, Frank Hilberg, Christoph Hoenke, Matthias Hoffmann, Maria Impagnatiello, Dirk Kessler, Christian Klein, Bernd Krist, Udo Maier, Darryl McConnell, Charlotte Reither, Stefan Scheuerer, Andreas Schoop, Norbert Schweifer, Oliver Simon, Martin Steegmaier, Steffen Steurer, Irene Waizenegger, Ulrike Weyer-Czernilofsky, Andreas Zoephel
  • Carbamic acid esters with anticholinergic activity
    Patent number: 7041674
    Abstract: A compound of formula 1 wherein X?, A, R1, R2, R3, and R4 may have the meanings given in the claims and in the specification, processes for preparing them, their use in pharmaceutical compositions, and methods of treating patients using them.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: May 9, 2006
    Assignee: Boehringer Ingelhiem Pharma GmbH & Co. KG
    Inventors: Steffen Breitfelder, Matthias Hoffmann, Matthias Grauert, Michael P. Pieper, Georg Speck
  • Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
    Publication number: 20060058344
    Abstract: The present invention relates to new compounds of general formula 1 wherein X? and the groups A, B, R, R1, R2, R3, R3?, R4, R4?, Rx and Rx? may have the meanings given in the claims and in the specification, processes for preparing them and their use as pharmaceutical compositions.
    Type: Application
    Filed: November 9, 2005
    Publication date: March 16, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Matthias Grauert, Michael Pieper, Gerald Pohl, Georg Speck, Steffen Breitfelder