Patent number: 6455538
Abstract: Compounds of general formula I
wherein X is a single bond, —O—, C-C4-alkylene, or an alkylene bridge having 1 to 8 carbon atoms which may be branched or unbranched and optionally have one or two oxygen atom(s) anywhere in the bridge; R1 is hydrogen, methyl, ethyl, or phenyl; R2 is hydrogen or methyl; R3 is hydrogen, fluorine, chlorine, bromine, hydroxy, methyl, or methoxy; R4 is hydrogen, methyl, or ethyl; R5 is hydrogen, methyl, or ethyl; R6 is hydrogen, methyl, or ethyl; R7 is tert-butyl, cyclohexyl, phenyl optionally substituted by R9 and R10, which may be identical or different, or;
R8 is hydrogen or C1-C4-alkyl; Z is oxygen, NH, or sulfur; R9 is hydrogen, methyl, fluorine, chlorine, bromine, or methoxy; R10 is hydrogen, methyl, fluorine, chlorine, bromine, or methoxy; optionally in the form of the individual optical isomers, mixtures of the individual enantiomers or racemates as well as in the form of the free bases or the corresponding acid addition salts
Type:
Grant
Filed:
March 10, 2000
Date of Patent:
September 24, 2002
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Matthias Grauert, Adrian Carter, Wolf-Dietrich Bechtel, Thomas Weiser, Rainer Palluk, Uwe Pschorn
Patent number: 6387921
Abstract: Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of general formula 1:
wherein:
R1 and R2, which are identical or different, are each hydrogen, C1-C6-alkyl, C1--C6-alkyloxy, OH, F, Cl, or Br;
R3 is hydrogen, F, Cl, Br, methyl, ethyl, OH, or methoxy;
R4 and R5, which are identical or different, are each hydrogen, methyl, or ethyl;
R6 is hydrogen;
X is NH2, NH—(C1-C6-alkyl), N(C1-C6-alkyl)2, the two C1-C6-alkyl groups of which are identical or different, NH—COH, NH—CO(C1-C6-alkyl), or F;
A is —(CH2)3—, —CH2—CH2—O—, —CH2—O—CH2—, —(CH2)4—, —CH(C1-C6-alkyl)-O—CH2—, —(CH2)2—O—CH2—, —(CH2)3—O—, —(CH2)5—, —CH2—O—(CH2)3—, —(CH2)2—O—(CH2)2—, —(CH2)3—O—CH2—, —(CH2)4—O—, —CH2—O—CH2—CH2—O—,
Type:
Grant
Filed:
November 27, 2001
Date of Patent:
May 14, 2002
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Matthias Grauert, Adrian Carter, Thomas Weiser, Helmut Ensinger, Wolfram Gaida, Joachim Mierau
Patent number: 6355652
Abstract: Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of general formula 1:
wherein:
R1 and R2, which may be identical or different, are each hydrogen, C1-C6-alkyl, C1-C6-alkyloxy, OH, F, Cl, or Br;
R3 is hydrogen, F, Cl, Br, methyl, ethyl, OH, or methoxy;
R4, R5, and R6, which may be identical or different, are each hydrogen, methyl, or ethyl;
X is NH2, NH-(C1-C6-alkyl), N(C1-C6-alkyl)2, the two C1-C6-alkyl groups of which may be identical or different, NH—COH, NH—CO(C1-C6-alkyl), or F;
A is —(CH2)3—, —CH2—CH2—O—, —CH2—O—CH2—, —(CH2)4—, —CH(C1-C6-alkyl)-O—CH2—, —(CH2)2—O—CH213 , —(CH2)3—O—, —(CH2)5—, —CH2—O—(CH2)3—, —(CH2)2—O—(CH2)2—, —(CH2)3—O—CH2—, —(CH2)4—O—, —CH2—O—CH2—CH2—O—,
the
Type:
Grant
Filed:
October 30, 2000
Date of Patent:
March 12, 2002
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Matthias Grauert, Adrian Carter, Thomas Weiser, Helmut Ensinger, Wolfram Gaida, Joachim Mierau
