Patents by Inventor Matthias Mann
Matthias Mann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240092826Abstract: The present invention relates to a method of purifying peptides and/or polypeptides, said method comprising or consisting of: (a) loading a sample comprising peptides and/or polypeptides under acidic or neutral aqueous conditions on mixed-phase solid phase extraction (SPE) material, wherein said material consists of or comprises reversed phase/ion exchange material; (b) washing said mixed-phase SPE material with (ba) an acidic or neutral composition comprising at least 50% (v/v) organic solvent; and/or (bb) an acidic or neutral aqueous solution; and (c) eluting said peptides and/or polypeptides from said mixed-phase SPE material with an alkaline composition comprising at least 50% (v/v) organic solvent.Type: ApplicationFiled: July 28, 2023Publication date: March 21, 2024Inventors: Nils A. KULAK, Garwin PICHLER, Matthias MANN
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Patent number: 11753437Abstract: The present invention relates to a method of purifying peptides and/or polypeptides, said method comprising or consisting of: (a) loading a sample comprising peptides and/or polypeptides under acidic or neutral aqueous conditions on mixed-phase solid phase extraction (SPE) material, wherein said material consists of or comprises reversed phase/ion exchange material; (b) washing said mixed-phase SPE material with (ba) an acidic or neutral composition comprising at least 50% (v/v) organic solvent; and/or (bb) an acidic or neutral aqueous solution; and (c) eluting said peptides and/or polypeptides from said mixed-phase SPE material with an alkaline composition comprising at least 50% (v/v) organic solvent.Type: GrantFiled: July 8, 2016Date of Patent: September 12, 2023Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.Inventors: Nils A. Kulak, Garwin Pichler, Matthias Mann
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Publication number: 20230158032Abstract: The present invention relates to the treatment of myeloproliferative neoplasms through targeted elimination of malignant clones and overcome of diseases persistence. The treatment is based on a combination of inhibitors of mRNA splicing and processing factors together with Jak inhibitors.Type: ApplicationFiled: April 23, 2021Publication date: May 25, 2023Inventors: Florian Heidel, Ashok Kumar Jayavelu, Matthias Mann
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Publication number: 20230087805Abstract: The present invention relates to inhibitors of the interaction between H. pylori HopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.Type: ApplicationFiled: September 21, 2022Publication date: March 23, 2023Applicants: TECHNISCHE UNIVERSITÄT MÜNCHEN, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Anahita JAVAHERI, Tobias KRUSE, Markus GERHARD, Bernhard B. SINGER, Daniel HORNBURG, Han REMAUT, Matthias MANN, Felix MEISSNER, Steffen BACKERT
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Patent number: 11471532Abstract: The present invention relates to inhibitors of the interaction between H. pylori IIopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.Type: GrantFiled: July 20, 2017Date of Patent: October 18, 2022Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG, DER WISSENSCHAFT EN E.V., TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Anahita Javaheri, Tobias Kruse, Markus Gerhard, Bernhard B. Singer, Daniel Hornburg, Han Remaut, Matthias Mann, Felix Meissner, Steffen Backert
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Patent number: 11355330Abstract: The present invention relates to use of an isobaric label in mass spectrometry (MS) analysis using data-independent acquisition (DIA), wherein said isobaric label comprises or consists of a group which fragments in the mass spectrometer (i) at an energy below the energy required for fragmenting analyte-derived precursor ions and/or a higher conversion rate than said precursor ions; and (ii) at said energy according to (i) and when coupled to a precursor ion, at a single site within said group, to yield a first moiety and a second moiety, said second moiety being coupled to said precursor ion.Type: GrantFiled: November 14, 2018Date of Patent: June 7, 2022Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAF 1 EN E.V.Inventors: Felix Meissner, Matthias Mann, Florian Meier, Sebastian Virreira Winter, Arturo Zychlinsky
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Publication number: 20220153797Abstract: The current disclosure relates to methods for treating ovarian cancer based on specific antigen expression of the cancer. Furthermore, the expressed antigen may be used in immunotherapeutic methods for treatment of the ovarian cancer. Aspects of the disclosure relate to immunotherapies targeting CT45 polypeptides, methods for treating ovarian cancer based on CT45 expression, and kits for detecting CT45 polypeptides and nucleotides.Type: ApplicationFiled: January 28, 2022Publication date: May 19, 2022Applicants: The University of Chicago, Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V.Inventors: Ernst Lengyel, Matthias Mann, Marion Curtis, Fabian Coscia
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Patent number: 11261223Abstract: The current disclosure relates to methods for treating ovarian cancer based on specific antigen expression of the cancer. Furthermore, the expressed antigen may be used in immunotherapeutic methods for treatment of the ovarian cancer. Aspects of the disclosure relate to immunotherapies targeting CT45 polypeptides, methods for treating ovarian cancer based on CT45 expression, and kits for detecting CT45 polypeptides and nucleotides.Type: GrantFiled: May 11, 2017Date of Patent: March 1, 2022Assignees: The University of Chicago, Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V.Inventors: Ernst Lengyel, Matthias Mann, Marion Curtis, Fabian Coscia
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Publication number: 20210008207Abstract: The present invention relates to inhibitors of the interaction between H. pylori IIopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.Type: ApplicationFiled: July 20, 2017Publication date: January 14, 2021Applicants: TECHNISCHE UNIVERSITÄT MÜNCHEN, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Anahita JAVAHERI, Tobias KRUSE, Markus GERHARD, Bernhard B. SINGER, Daniel HORNBURG, Han REMAUT, Matthias MANN, Felix MEISSNER, Steffen BACKERT
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Patent number: 10828358Abstract: The present invention relates to immunogenic compositions and their use in the prevention or treatment of diseases or disorders caused by or associated with Helicobacter pylori, in particular H. pylori infection and gastroduodenal disorders caused by H. pylori. The present invention further relates to methods of detecting H. pylori infection in a subject.Type: GrantFiled: December 14, 2016Date of Patent: November 10, 2020Assignees: TECHNISCHE UNIVERSITÄT MÜNCHEN, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Tobias Kruse, Daniel Hornburg, Markus Gerhard, Matthias Mann, Felix Meissner
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Publication number: 20200286721Abstract: The present invention relates to use of an isobaric label in mass spectrometry (MS) analysis using data-independent acquisition (DIA), wherein said isobaric label comprises or consists of a group which fragments in the mass spectrometer (i) at an energy below the energy required for fragmenting analyte-derived precursor ions and/or a higher conversion rate than said precursor ions; and (ii) at said energy according to (i) and when coupled to a precursor ion, at a single site within said group, to yield a first moiety and a second moiety, said second moiety being coupled to said precursor ion.Type: ApplicationFiled: November 14, 2018Publication date: September 10, 2020Inventors: Felix MEISSNER, Matthias MANN, Florian MEIER, Sebastian VIRREIRA WINTER, Arturo ZYCHLINSKY
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Publication number: 20190369112Abstract: The present invention relates to a compound which comprises or consists of (a) a reactive moiety, said reactive moiety being capable of reacting with a functional group of a peptide to form a covalent bond; and covalently joined thereto (b) a moiety which fragments in the mass spectrometer (i) at an energy below the energy required for fragmenting peptides and/or a higher conversion rate than peptides; and (ii) at said energy according to (i) and when coupled to a peptide via said reactive group, at a single site within said compound coupled to a peptide, to yield a first moiety and a second moiety, said second moiety being coupled to said peptide.Type: ApplicationFiled: November 14, 2017Publication date: December 5, 2019Inventors: Felix MEISSNER, Matthias MANN, Florian MEIER, Sebastian VIRREIRA WINTER, Arturo ZYCHLINSKY
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Publication number: 20190144516Abstract: The current disclosure relates to methods for treating ovarian cancer based on specific antigen expression of the cancer. Furthermore, the expressed antigen may be used in immunotherapeutic methods for treatment of the ovarian cancer. Aspects of the disclosure relate to immunotherapies targeting CT45 polypeptides, methods for treating ovarian cancer based on CT45 expression, and kits for detecting CT45 polypeptides and nucleotides.Type: ApplicationFiled: May 11, 2017Publication date: May 16, 2019Inventors: Ernst Lengyel, Matthias Mann, Marion Curtis, Fabian Coscia
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Publication number: 20180360941Abstract: The present invention relates to immunogenic compositions and their use in the prevention or treatment of diseases or disorders caused by or associated with Helicobacter pylori, in particular H. pylori infection and gastroduodenal disorders caused by H. pylori. The present invention further relates to methods of detecting H. pylori infection in a subject.Type: ApplicationFiled: December 14, 2016Publication date: December 20, 2018Applicants: TECHNISCHE UNIVERSITÄT MÜNCHEN, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSC HAFTEN E.V.Inventors: Tobias KRUSE, Daniel HORNBURG, Markus GERHARD, Matthias MANN, Felix MEISSNER
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Publication number: 20180217156Abstract: The present invention relates to a use of a tertiary amine as buffer in sample preparation, preferably for mass spectrometry and/or UV/vis spectroscopy, wherein the sample comprises proteins, polypeptides and/or peptides, and said sample preparation comprises: (a) protein, polypeptide and peptide denaturation; and (b) chemical isotope labelling and/or chemical cross-linking, wherein said sample preparation does not use primary amine buffers.Type: ApplicationFiled: July 28, 2016Publication date: August 2, 2018Inventors: Nils A. KULAK, Garwin PICHLER, Matthias MANN
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Publication number: 20180201644Abstract: The present invention relates to a method of purifying peptides and/or polypeptides, said method comprising or consisting of: (a) loading a sample comprising peptides and/or polypeptides under acidic or neutral aqueous conditions on mixed-phase solid phase extraction (SPE) material, wherein said material consists of or comprises reversed phase/ion exchange material; (b) washing said mixed-phase SPE material with (ba) an acidic or neutral composition comprising at least 50% (v/v) organic solvent; and/or (bb) an acidic or neutral aqueous solution; and (c) eluting said peptides and/or polypeptides from said mixed-phase SPE material with an alkaline composition comprising at least 50% (v/v) organic solvent.Type: ApplicationFiled: July 8, 2016Publication date: July 19, 2018Inventors: Nils A. KULAK, Garwin PICHLER, Matthias MANN
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Publication number: 20180067021Abstract: The present invention relates to sample preparation container for purification and/or enrichment of bio-organic compounds from cellular material, viruses and/or sub-components of said cellular material and/or viruses, the container comprising a reaction chamber and a chromatography medium; wherein said reaction chamber is for holding said cellular material, viruses and/or sub-components of said cellular material and/or viruses and is configured such that at least one of the following reactions can be performed therein: lysis, e.g.Type: ApplicationFiled: September 13, 2017Publication date: March 8, 2018Inventors: Nils A. KULAK, Matthias MANN, Seyed Babak AZIMIFAR, Nagarjuna NAGARAJ
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Patent number: 9891194Abstract: The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer (“TIMS”) is used as the ion mobility separator separation device. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with up-front substance separator. TIMS with parallel accumulation provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species to improve the quality of the fragment ion spectra.Type: GrantFiled: November 3, 2015Date of Patent: February 13, 2018Assignees: Bruker Daltonik GmbHInventors: Matthias Mann, Oliver Räther, Melvin Andrew Park, Markus Lubeck
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Publication number: 20180031528Abstract: The present invention relates to a device for preventing band broadening and remixing of separated fractions, and associated method, comprising a chromatographic column coupled to a flow selector, such as a rotary valve, wherein said flow selector is connected to the distal end of said column such that the sum of post-column swept volume and post-column dead volume is less than 10 ?L. Preferably, the column is directly plugged into the inlet port of the rotary valve and the sample is fractionated at the outlet port.Type: ApplicationFiled: February 5, 2016Publication date: February 1, 2018Inventors: Nils KULAK, Matthias MANN
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Patent number: 9791355Abstract: Disclosed is a sample preparation container for purification and/or enrichment of bio-organic compounds from cellular material, viruses and/or sub-components of these. The container includes a reaction chamber and a chromatography medium. The reaction chamber is for holding the cellular material, etc. and is configured to perform reactions inside. The chromatography medium is configured to purify the bio-organic compounds. The chromatography medium is located at a wall of the reaction chamber, and the wall is closed or sealed and configured to be opened for obtaining purified bio-organic compounds. The sample preparation container further includes a receiving chamber for receiving the bio-organic compounds, that is adjacent to the chromatography medium such that the chromatography medium separates the reaction chamber from the receiving chamber. The outer face of the receiving chamber is closed and configured to be opened for obtaining purified bio-organic compounds.Type: GrantFiled: December 19, 2013Date of Patent: October 17, 2017Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Nils A. Kulak, Matthias Mann, Seyed Babak Azimifar, Nagarjuna Nagaraj