Patents by Inventor Matthias Schaefer

Matthias Schaefer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130079358
    Abstract: The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R1, R2, R3 and X are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: January 12, 2011
    Publication date: March 28, 2013
    Applicant: SANOFI
    Inventors: Dieter Kadereit, Matthias Schaefer, Stephanie Hachtel, Axel Dietrich, Thomas Huebschle, Katrin Hiss
  • Publication number: 20130072502
    Abstract: Heterocyclic carboxylic acid derivatives comprising a 2,5-substituted oxazolopyrimidine ring as Edg-1 receptor agonists The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R1, R2, R3, X and Y are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: January 12, 2011
    Publication date: March 21, 2013
    Applicant: SANOFI
    Inventors: Dieter Kadereit, Matthias Schaefer, Stephanie Hachtel, Axel Dietrich, Thomas Huebschle, Katrin Hiss
  • Publication number: 20130072501
    Abstract: The invention relates to oxazolopyrimidine compounds of formula I, where A, R1 and R2 are defined as stated in the claims. The compounds of formula I are suitable, for example, for wound healing.
    Type: Application
    Filed: January 14, 2011
    Publication date: March 21, 2013
    Applicant: SANOFI
    Inventors: Dieter Kadereit, Matthias Schaefer, Stephanie Hachtel, Axel Dietrich, Thomas Huebschle, Katrin Hiss
  • Patent number: 8362073
    Abstract: The present invention relates to compounds of the formula I, wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: January 29, 2013
    Assignee: Sanofi
    Inventors: Matthias Schaefer, Josef Pernerstorfer, Dieter Kadereit, Hartmut Strobel, Werngard Czechtizky, L. Charlie Chen, Alena Safarova, Aleksandra Weichsel, Marcel Patek
  • Publication number: 20130023557
    Abstract: The invention therefore relates to compounds of the formula I in which X, Y, R1, R2 and R3 have the given meanings. The compounds of the formula I are suitable, for example, for wound healing.
    Type: Application
    Filed: June 25, 2012
    Publication date: January 24, 2013
    Applicant: SANOFI
    Inventors: Dieter KADEREIT, Matthias SCHAEFER, Stephanie HACHTEL, Thomas HUEBSCHLE, Katrin HISS
  • Publication number: 20130023558
    Abstract: Carboxylic acid derivatives having an oxazolo[4,5-c]pyridine ring The invention therefore relates to compounds of the formula I in which X, Y, R1, R2 and R3 have the given meanings. The compounds of the formula I are suitable, for example, for wound healing.
    Type: Application
    Filed: June 25, 2012
    Publication date: January 24, 2013
    Applicant: SANOFI
    Inventors: Dieter KADEREIT, Matthias SCHAEFER, Stephanie HACHTEL, Thomas HUEBSCHLE, Katrin HISS
  • Publication number: 20130023544
    Abstract: The invention therefore relates to compounds of the formula I in which A, X, Y, R1, R2 and R3 have the given meanings. The compounds of the formula I are suitable, for example, for wound healing.
    Type: Application
    Filed: June 25, 2012
    Publication date: January 24, 2013
    Applicant: SANOFI
    Inventors: Dieter KADEREIT, Matthias SCHAEFER, Stephanie HACHTEL, Thomas HUEBSCHLE, Katrin HISS
  • Publication number: 20130023545
    Abstract: The present invention relates to cycloalkyloxycarboxylic acid derivatives of the formula I in which A, R1, R2a, R2b, R2c, R3 and X are as defined in the claims. The compounds of the formula I are suitable, for example, for wound healing.
    Type: Application
    Filed: June 25, 2012
    Publication date: January 24, 2013
    Applicant: SANOFI
    Inventors: Dieter KADEREIT, Matthias SCHAEFER, Stephanie HACHTEL, Thomas HUEBSCHLE, Katrin HISS, Silke HAAG-DIERGARTEN
  • Patent number: 8342788
    Abstract: A chiplessly thread-forming screw has a stem (11) at one end of which a tip (13) is provided and at another end of which a head (14) is provided, and which has a pointed conical section (21) extending from the tip (13) in a direction of the head (14), a cylindrical section (25) arranged between the first pointed section (21) and the head (14), a first cambered section (22) adjoining the pointed conical section (21) in the direction of the head, and a second cambered section (24) arranged between the first cambered section (22) and the cylindrical section (25) and an outer surface (16) of which has a second curvature radius (R2) unequal to the first curvature radius (R1) of the outer surface (12) of the first cambered section (21).
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: January 1, 2013
    Assignee: Hilti Aktiengesellschaft
    Inventors: Sven Matthiesen, Frank Rieger, Peter Hertlein, Michael Baumgartner, Peter Mugg, Matthias Schaefer
  • Publication number: 20120287744
    Abstract: The invention provides a mixing system comprising the following: A) at least one extensional flow mixer comprising: a generally open and hollow body having a contoured outer surface and having: a single entrance port and a single exit port; a means for compressing a bulk stream flowing through the generally open and hollow body in a direction of flow, and at least one injected additive stream introduced at the single entrance port in the direction of flow; and a means for broadening the bulk stream and the at least one injected additive stream, such that an interfacial area between the bulk stream and the at least one injected additive stream is increased as the bulk stream and the at least one injected additive stream flow through the generally open and hollow body in the direction of flow to promote mixing of the bulk stream and the at least one injected additive stream; B) a flow conductor having an axis and having a generally open and hollow flow mixer body cured therein; and C) a primary additive stream
    Type: Application
    Filed: January 20, 2011
    Publication date: November 15, 2012
    Applicant: Dow Global Technologies LLC
    Inventors: Maria Pollard, Steven R. Strand, David A. Eversdyk, Matthias Schaefer
  • Publication number: 20120264790
    Abstract: The present invention relates to compounds of the formula I, wherein A, Y, Z, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
    Type: Application
    Filed: May 1, 2012
    Publication date: October 18, 2012
    Applicant: SANOFI
    Inventors: Josef PERNERSTORFER, Heinz-Werner KLEEMANN, Matthias SCHAEFER, Alena SAFAROVA, Marcel PATEK
  • Publication number: 20120253001
    Abstract: Insulated glass units are sealed with polyurethane made using a natural oil-based polyol (NOBP). In one embodiment the NOBP is made using a monol-rich monomer containing high levels of mono-hydroxy functional fatty acid methyl esters. Insulated glass sealants based on these compounds provide enhanced resistance to UV and oxidative degradation as compared to conventional products while still providing the required barrier and mechanical properties.
    Type: Application
    Filed: November 15, 2010
    Publication date: October 4, 2012
    Inventors: Bindushree Radhakrishnan, Dwight D. Latham, Laura A. Grier, William A. Koonce, Matthias Schaefer, Paul D. Ries
  • Publication number: 20120238769
    Abstract: Natural oil-based polyols that are high in color, e.g., >40 APHA, are decolorized when exposed to high frequency visible light and/or low frequency UV light, with or without the combination of heat and/or air exposure.
    Type: Application
    Filed: November 15, 2010
    Publication date: September 20, 2012
    Inventors: David A. Babb, Matthias Schaefer
  • Publication number: 20120226188
    Abstract: The invention relates to a medical device for infusion of an active ingredient or removal of a body tissue or body liquid comprising: a outlet device for infusion of an active ingredient to a body tissue; a receptacle for storing the active ingredient to which the outlet device is attachable; a sensor device for measuring a parameter which is related to a physical state in the body tissue; a drive device for effectuating at least an infusion of the active ingredient; characterized by a control unit functionally connected to the sensor device for receiving a sensor signal, which corresponds to the state of the body tissue, wherein the control unit is adapted for controlling a flow rate.
    Type: Application
    Filed: August 27, 2010
    Publication date: September 6, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Matthias Schaefer, Andreas Gille
  • Publication number: 20110190490
    Abstract: The present invention relates to oxazolopyrimidine compounds of the formula I in which A, R1, R2 and R3 are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: July 2, 2009
    Publication date: August 4, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Dieter Kadereit, Matthias Schaefer, Werngard Czechtizky
  • Publication number: 20110182134
    Abstract: A mixing system is disclosed comprising at least one extensional flow mixer comprising: a generally open and hollow body having a contoured outer surface and having: a single entrance port and a single exit port; a means for compressing a bulk stream flowing through the generally open and hollow body in a direction of flow and at least one injected additive stream introduced at the single entrance port in the direction of flow; and a means for broadening the bulk stream and the at least one injected additive stream such that an interfacial area between the bulk stream and the at least one injected additive stream is increased as the bulk stream and the at least one injected additive stream flow through the generally open and hollow body in the direction of flow to promote mixing of the bulk stream and the at least one injected additive stream, a flow conductor having an axis and having a generally open and hollow flow mixer body secured therein; and a primary additive stream injector positioned at the entra
    Type: Application
    Filed: January 22, 2010
    Publication date: July 28, 2011
    Applicant: Dow Global Technologies Inc.
    Inventors: Maria Pollard, Steven R. Strand, David A. Eversdyk, Matthias Schaefer
  • Publication number: 20110152290
    Abstract: The present invention relates to compounds of the formula I, wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
    Type: Application
    Filed: November 4, 2010
    Publication date: June 23, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Matthias SCHAEFER, Josef PERNERSTORFER, Dieter KADEREIT, Hartmut STROBEL, Werngard CZECHTIZKY, L. Charlie CHEN, Alena SAFAROVA, Aleksandra WEICHSEL, Marcel PATEK
  • Publication number: 20100307337
    Abstract: A gas mixer (10) for mixing a first gas stream with a second gas stream includes an impact labyrinth (24) in the first gas stream having structures (25), e.g., corrugated walls, forming a tortuous path through which the first gas stream must pass en route to a mixing point (20) in the gas mixer. The labyrinth fosters ignition of particles entrained in the first gas stream. Elongate, straight pipes (30) receive the first gas stream from the impact labyrinth (24) and carrying the first gas stream to the mixing point (20) the pipes (30) are positioned with a vessel (12) carrying the second gas stream. The pipes (30) have openings which are substantially aligned with the flow direction of the second gas stream at the mixing point (20) thereby introducing the first gas stream into the second gas stream in a low shear manner.
    Type: Application
    Filed: November 12, 2008
    Publication date: December 9, 2010
    Applicant: DOW TECHNOLOGY INVESTMENTS LLC
    Inventors: Harvey E. Andresen, Christopher P. Christenson, Charles W. Lipp, John R. Mayer, Thomas J. Kling, Victor R. Fey, Laurence G. Britton, Michael J. Rangitsch, Michael L. Hutchison, Matthias Schaefer
  • Publication number: 20100266567
    Abstract: The invention relates to the use of a urate oxidase, preferably recombinant urate oxidase, for example rasburicase, for the treatment or prophylaxis of disorders or indirect sequelae of the heart caused by ischemic or reperfusion events, for example during and after cardiac surgery like CABG (coronary artery bypass graft), PCI (percutaneous coronary intervention), transplantation, post myocardial infarction and for the treatment or prophylaxis of coronary artery disease or heart failure, for example congestive heart failure.
    Type: Application
    Filed: March 1, 2010
    Publication date: October 21, 2010
    Applicant: sanofi-aventis
    Inventors: Wolfgang LINZ, Matthias SCHAEFER
  • Patent number: 7510057
    Abstract: A parking brake for a commercial vehicle equipped with an air-operated service brake is configured in such a way that the actuating energy for the brake is reduced in comparison to a configuration with a spring brake cylinder, while the installation space in the wheel area is minimized. Primary functional parts of the parking brake include an inner race and an outer race, which delimit an annular gap. Displaceable tapered-roller bearings are located in the annular gap. To adopt a release position in opposition to the action of a compression spring, the tapered roller bearings are disengaged from the conical surfaces of the inner race and the outer race.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: March 31, 2009
    Assignee: Knorr-Bremse Systeme Fuer Nutzfahrzeuge GmbH
    Inventors: Wolfgang Kiener, Stephan Lange, Johann Baumgartner, Eduard Gerum, Michael Herges, Dirk Ganzhorn, Bence Csàk, Nicolas Savagner, Uwe Neumann, Matthias Gradl, Matthias Schaefer