Abstract: The present invention relates to oxazolopyrimidine compounds of the formula I in which A, R1, R2 and R3 are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

Abstract: A mixing system is disclosed comprising at least one extensional flow mixer comprising: a generally open and hollow body having a contoured outer surface and having: a single entrance port and a single exit port; a means for compressing a bulk stream flowing through the generally open and hollow body in a direction of flow and at least one injected additive stream introduced at the single entrance port in the direction of flow; and a means for broadening the bulk stream and the at least one injected additive stream such that an interfacial area between the bulk stream and the at least one injected additive stream is increased as the bulk stream and the at least one injected additive stream flow through the generally open and hollow body in the direction of flow to promote mixing of the bulk stream and the at least one injected additive stream, a flow conductor having an axis and having a generally open and hollow flow mixer body secured therein; and a primary additive stream injector positioned at the entra

Abstract: The present invention relates to compounds of the formula I, wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

Abstract: The present invention relates to drug delivery systems in the form of thin water-soluble films (wafers), which contain estradiol, or derivatives thereof, in low amounts. The wafers of the present invention are suitable for treating, alleviating or preventing a physical condition in a female mammal caused by insufficient endogenous levels of estrogen.

Abstract: A gas mixer (10) for mixing a first gas stream with a second gas stream includes an impact labyrinth (24) in the first gas stream having structures (25), e.g., corrugated walls, forming a tortuous path through which the first gas stream must pass en route to a mixing point (20) in the gas mixer. The labyrinth fosters ignition of particles entrained in the first gas stream. Elongate, straight pipes (30) receive the first gas stream from the impact labyrinth (24) and carrying the first gas stream to the mixing point (20) the pipes (30) are positioned with a vessel (12) carrying the second gas stream. The pipes (30) have openings which are substantially aligned with the flow direction of the second gas stream at the mixing point (20) thereby introducing the first gas stream into the second gas stream in a low shear manner.

Abstract: The invention relates to the use of a urate oxidase, preferably recombinant urate oxidase, for example rasburicase, for the treatment or prophylaxis of disorders or indirect sequelae of the heart caused by ischemic or reperfusion events, for example during and after cardiac surgery like CABG (coronary artery bypass graft), PCI (percutaneous coronary intervention), transplantation, post myocardial infarction and for the treatment or prophylaxis of coronary artery disease or heart failure, for example congestive heart failure.

Abstract: A parking brake for a commercial vehicle equipped with an air-operated service brake is configured in such a way that the actuating energy for the brake is reduced in comparison to a configuration with a spring brake cylinder, while the installation space in the wheel area is minimized. Primary functional parts of the parking brake include an inner race and an outer race, which delimit an annular gap. Displaceable tapered-roller bearings are located in the annular gap. To adopt a release position in opposition to the action of a compression spring, the tapered roller bearings are disengaged from the conical surfaces of the inner race and the outer race.

Abstract: A chiplessly thread-forming screw has a stem (11) at one end of which a tip (13) is provided and at another end of which a head (14) is provided, and which has a pointed conical section (21) extending from the tip (13) in a direction of the head (14), a cylindrical section (25) arranged between the first pointed section (21) and the head (14), a first cambered section (22) adjoining the pointed conical section (21) in the direction of the head, and a second cambered section (24) arranged between the first cambered section (22) and the cylindrical section (25) and an outer surface (16) of which has a second curvature radius (R2) unequal to the first curvature radius (R1) of the outer surface (12) of the first cambered section (21).

Abstract: A parking brake for a commercial vehicle equipped with an air-operated service brake is configured in such a way that the actuating energy for the brake is reduced in comparison to a configuration with a spring brake cylinder, while the installation space in the wheel area is minimized. Primary functional parts of the parking brake include an inner race and an outer race, which delimit an annular gap. Displaceable tapered-roller bearings are located in the annular gap. To adopt a release position in opposition to the action of a compression spring, the tapered roller bearings are disengaged from the conical surfaces of the inner race and the outer race.

Abstract: The present invention relates to the arrangement of a stator and a spare stator. In order to avoid a permanent correction in the length of the driving shaft, the spare stator is connected to the instantaneously operated stator or is configured in a single piece. Upon occurrence of a defined amount of wear, this stator combination is merely reversed through 180° relative to the longitudinal axis or an intermediate tube is inserted so that the spare stator arrives in the rotor region.

Abstract: The present invention relates to the arrangement of a stator and a spare stator. In order to avoid a permanent correction in the length of the driving shaft, the spare stator is connected to the instantaneously operated stator or is configured in a single piece. Upon occurrence of a defined amount of wear, this stator combination is merely reversed through 180° relative to the longitudinal axis or an intermediate tube is inserted so that the spare stator arrives in the rotor region.

Abstract: Compounds of Formula I, and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation ##STR1## wherein X, Y, J, R.sup.1, and R.sup.2 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling undesired vegetation which involves contacting the vegetation or its environment with an effective amount of a compound of Formula I.