Abstract: System (SYS) for supporting X-ray imaging and related methods. The system (SYS) comprises a machine learning module (MLM), a logic (LG) configured to compute output correction information for adjusting an imaging geometry of an X-ray imaging apparatus to achieve a target imaging geometry. A modulator (MOD,L-MOD, H-MOD, S-MOD) is the system is configured to provide a user instruction for imaging geometry adjustment. The user instruction is modulated based on the output correction information. The machine learning module was previously trained on training data including a specific user's responses to previous instructions.

Abstract: An X-ray detector comprises a first scintillator layer, a second scintillator layer, a first photodiode array, a second photodiode array, and at least one light emitting layer. The first scintillator layer is configured to absorb X-rays from an X-ray pulse and emit light. The first photodiode array is positioned adjacent to the first scintillator layer and is configured to detect at least some of the light emitted by the first scintillator layer. The second scintillator layer is configured to absorb X-rays from the X-ray pulse and emit light. The second photodiode array is positioned adjacent to the second scintillator layer and is configured to detect at least some of the light emitted by the second scintillator layer. The at least one light emitting layer is configured to emit radiation such that at least some of the emitted radiation irradiates the first photodiode array, and at least some of the emitted radiation irradiates the second photodiode array.

Abstract: A detector includes a first detection layer (1141) and a second detector layer (1142). The first and second detection layers include a first and second scintillator (204, 7041) (216, 7042), a first and second active photosensing region (210, 7081) (220, 7082), a first portion (206, 7261) of a first substrate (208, 7061), and a second portion (218, 7262) of a second substrate (208, 7062). An imaging system (100) includes a radiation source (110), a radiation sensitive detector array (108) comprising a plurality of multi-layer detectors (112), and a reconstructor (118) configured to reconstruct an output of the detector array and produces an image. The detector array includes a first detection layer and a second detector layer with a first and second scintillator, a first and second active photosensing region, a first portion of a first substrate, and a second portion of a second substrate.

Abstract: Typically, a dual layer multi-spectral X-ray detector is capable of providing two points of spectral data about an imaged sample, because the front X-ray detector also acts to filter part of an incident X-ray spectrum before detection by a rear X-ray detector. A pre-filter can be placed in front of the front X-ray detector to enhance the spectral separation. However, the provision of a pre-filter implies that the intensity of the X-ray radiation must be increased to achieve the same signal to noise ratio. The present application concerns a multi-spectral X-ray detector with a front X-ray detector, a rear X-ray detector, and a structured spectral filter placed in-between them. The structured spectral filter has first and second regions configured to sample superpixels of the front X-ray detector, enabling three separate items of spectral information to be obtained per superpixel.

Abstract: The invention relates to an analyzing grid for phase contrast imaging and/or dark-field imaging, a detector arrangement for phase contrast imaging and/or dark-field imaging comprising such analyzing grid, an X-ray imaging system comprising such detector arrangement, a method for manufacturing such analyzing grid, a computer program element for controlling such analyzing grid or detector arrangement for performing such method and a computer readable medium having stored such computer program element. The analyzing grid comprises a number of X-ray converting gratings. The X-ray converting gratings are configured to convert incident X-ray radiation into light or charge. The number of X-ray converting gratings comprises at least a first X-ray converting grating and a second X-ray converting grating.

Abstract: In the present invention a direct X-ray conversion layer comprises a material having a perovskite crystal structure. This is preferable since this enables constructing an X-ray detector with edge-on illuminated detector elements.

Abstract: The invention relates to a method for producing a radiation detector used to detect ionizing radiation including a first inorganic-organic halide Perovskite material (24) as a direct converter material and/or as a scintillator material in a detector layer and to a radiation detector comprising a detector layer (24) produced by means of the steps of the method. In order to provide an approach for producing a thick layer (e.g. above 10 ???) of Perovskite material suitable for a radiation detector, it is proposed to grow the material selectively on a seeding layer (23), yielding in a thick polycrystalline layer. One suitable seeding layer (23) to grow lead Perovskite material is made of a bromide Perovskite material.

Abstract: The teachings of the present disclosure may be employed for buffering electric power in a virtual storage power plant. For example, a virtual power plant for buffering electric power may include: distributed electrical energy storage systems electrically interconnected by transmission lines of an electrical power plant network; a measuring device detecting a state of charge of each of the storage systems; and a control device adjusting the states of charge between a lower limit and an upper limit. The states of charge are adjusted as needed by means of a charge equalization including transmitting electrical equalization charges from energy storage systems having a relatively high state of charge to energy storage systems having a relatively low state of charge, via the electrical power plant network.

Abstract: The present invention relates to medical imaging, and in particular a medical imaging detector. In order to improve and facilitate the collection of information, e.g. for medical diagnosis, a medical imaging detector is provided that comprises a first sensor arrangement (12) and a second sensor arrangement (14). The first sensor arrangement is configured to provide a first type of image data belonging to a first imaging modality. The second sensor arrangement is configured to provide a second type of image data belonging to a second imaging modality. The first imaging modality is an X-ray imaging modality, while the second imaging modality is a non-X-ray imaging modality. The first sensor arrangement comprises one or a plurality of first sensor segments (16) arranged within a first circumferential line (18) defining a first imaging area (20).

Abstract: In the present invention a direct X-ray conversion layer comprises a material having a perovskite crystal structure. This is preferable since this enables constructing an X-ray detector with edge-on illuminated detector elements.

Abstract: An anti-scatter device (ASG) filled with a filler material. The filler material (202) has an acoustic impedance that corresponds to that of human or animal tissue. Furthermore a hybrid X-ray/ultrasound imager (IM) including such an anti-scatter GA device (ASG).

Abstract: The teachings of the present disclosure may be employed for buffering electric power in a virtual storage power plant. For example, a virtual power plant for buffering electric power may include: distributed electrical energy storage systems electrically interconnected by transmission lines of an electrical power plant network; a measuring device detecting a state of charge of each of the storage systems; and a control device adjusting the states of charge between a lower limit and an upper limit. The states of charge are adjusted as needed by means of a charge equalization including transmitting electrical equalization charges from energy storage systems having a relatively high state of charge to energy storage systems having a relatively low state of charge, via the electrical power plant network.

Abstract: The invention relates to a radiation detector (100) and to a method for manufacturing such a detector. In a preferred embodiment, the radiation detector (100) comprises an array of photosensitive pillars (110) that are embedded in a conversion material (120). The photosensitive pillars may particularly be diodes connected at their ends to external circuits (130, 140). The conversion material (120) may particularly comprise a powder of scintillator particles (121) embedded in a matrix of binder.

Abstract: A radiation detector device for detecting a primary radiation includes a scintillator which generates a converted primary radiation in response to incoming primary radiation and a photo detector for detecting the converted primary radiation. The radiation detector device further includes a secondary radiation source for irradiating the scintillator with a secondary radiation which has a wavelength different from a wavelength of the first radiation and which is capable of producing a spatially more uniform response of the scintillator to primary radiation.

Abstract: The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma. Moreover, methods for determining whether a treatment with the compounds of the invention is suitable for a patient are disclosed.

Abstract: The invention relates to a radiation detector (100) and to a method for manufacturing such a detector. In a preferred embodiment, the radiation detector (100) comprises an array of photosensitive pillars (110) that are embedded in a conversion material (120). The photosensitive pillars may particularly be diodes connected at their ends to external circuits (130, 140). The conversion material (120) may particularly comprise a powder of scintillator particles (121) embedded in a matrix of binder.

Abstract: The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.

Abstract: The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma. Moreover, methods for determining whether a treatment with the compounds of the invention is suitable for a patient are disclosed.

Abstract: The present invention relates to a radiation detector with organic photodiodes and to a method of producing such a radiation detector. The TFT backplane (103, 104) is placed between the scintillator (101) and the organic photodiode layer stack (105, 106, 107, 108). This implies the use of transparent TFT-electronics, e.g., a-Si with back-thinned glass or an organic TFT on foil. The geometrical order enables a multitude of possible stack built- ups for OPDs and has advantages for encapsulation and manufacturing.

Abstract: A method for sensing input signal changes at an input of an input/output module operated in an automation system in which a signal is sampled by an input/output module. A change event and a timestamp associated with the change event are generated when a change in the sampled signal occurs and a value pair comprising the change event and the timestamp is stored in a higher-ranking automation component to the input/output module. The input/output module and the higher-ranking automation component are operated clock-synchronously with respect to one another by a clock pulse, and the timestamp is calculated centrally on the higher-ranking automation component based on the clock-synchronous operation.