Abstract: The invention relates to a radiation detector (100) and to a method for manufacturing such a detector. In a preferred embodiment, the radiation detector (100) comprises an array of photosensitive pillars (110) that are embedded in a conversion material (120). The photosensitive pillars may particularly be diodes connected at their ends to external circuits (130, 140). The conversion material (120) may particularly comprise a powder of scintillator particles (121) embedded in a matrix of binder.

Abstract: A radiation detector device for detecting a primary radiation includes a scintillator which generates a converted primary radiation in response to incoming primary radiation and a photo detector for detecting the converted primary radiation. The radiation detector device further includes a secondary radiation source for irradiating the scintillator with a secondary radiation which has a wavelength different from a wavelength of the first radiation and which is capable of producing a spatially more uniform response of the scintillator to primary radiation.

Abstract: The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma. Moreover, methods for determining whether a treatment with the compounds of the invention is suitable for a patient are disclosed.

Abstract: The invention relates to a radiation detector (100) and to a method for manufacturing such a detector. In a preferred embodiment, the radiation detector (100) comprises an array of photosensitive pillars (110) that are embedded in a conversion material (120). The photosensitive pillars may particularly be diodes connected at their ends to external circuits (130, 140). The conversion material (120) may particularly comprise a powder of scintillator particles (121) embedded in a matrix of binder.

Abstract: The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.

Abstract: A method for operating an internal combustion engine is described, the internal combustion engine including a cylinder having an inlet valve for supplying fresh air from an intake manifold in a controlled manner, an air filling being set in a certain operating mode by predefining a closing point in time of the inlet valve in an intake stroke at a constant intake manifold pressure.

Abstract: The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma. Moreover, methods for determining whether a treatment with the compounds of the invention is suitable for a patient are disclosed.

Abstract: The present invention relates to a radiation detector with organic photodiodes and to a method of producing such a radiation detector. The TFT backplane (103, 104) is placed between the scintillator (101) and the organic photodiode layer stack (105, 106, 107, 108). This implies the use of transparent TFT-electronics, e.g., a-Si with back-thinned glass or an organic TFT on foil. The geometrical order enables a multitude of possible stack built- ups for OPDs and has advantages for encapsulation and manufacturing.

Abstract: In a method for adapting a torque model for operating an internal combustion engine, which torque model indicates an ignition angle adjustment as a function of an air charge in a cylinder of the internal combustion engine, the torque model is adapted based on a variation of an operating variable of the internal combustion engine caused by a mode switching.

Abstract: A method for sensing input signal changes at an input of an input/output module operated in an automation system in which a signal is sampled by an input/output module. A change event and a timestamp associated with the change event are generated when a change in the sampled signal occurs and a value pair comprising the change event and the timestamp is stored in a higher-ranking automation component to the input/output module. The input/output module and the higher-ranking automation component are operated clock-synchronously with respect to one another by a clock pulse, and the timestamp is calculated centrally on the higher-ranking automation component based on the clock-synchronous operation.

Abstract: According to an exemplary embodiment of the invention a detector unit 301 for detecting electro-magnetic radiation may be provided. The detector unit 301 may comprise a conversion material 332 adapted for converting impinging electro-magnetic radiation into electric charge carriers. Moreover, the detector unit 301 may comprise a charge collection electrode 331 adapted for collecting the converted electric 321 charge carriers and an evaluation circuit 312, 313, 314 adapted for evaluating the electro-magnetic radiation based on the collected electric charge carriers. Moreover, the detector unit 301 may comprise a semiconductor 373 which may be electrically coupled between the charge 331 collection electrode 331 and the evaluation circuit 312, 313, 314.

Abstract: A detector unit (301) for detecting electromagnetic radiation (106), the detector unit (301) comprising a conversion material (332) adapted for converting impinging electromagnetic radiation (106) into electric charge carriers, a charge collection electrode (331) adapted for collecting the converted electric charge carriers, a shielding electrode (334, 335) adapted to form a capacitance with the charge collection electrode (331), and an evaluation circuit (312 to 315) electrically coupled with the charge collection electrode (331) and adapted for evaluating the electromagnetic radiation (106) based on the collected electric charge carriers.

Abstract: A method for sensing input signal changes at an input of an input/output module operated in an automation system in which a signal is sampled by an input/output module. A change event and a timestamp associated with the change event are generated when a change in the sampled signal occurs and a value pair comprising the change event and the timestamp is stored in a higher-ranking automation component to the input/output module. The input/output module and the higher-ranking automation component are operated clock-synchronously with respect to one another by a clock pulse, and the timestamp is calculated centrally on the higher-ranking automation component based on the clock-synchronous operation.

Abstract: The application describes an X-ray detector, which uses direct X-ray conversion (DiCo) combined with CMOS pixel circuits. DiCo materials have to be used with high voltage to achieve a high field strength. This makes the sensor prone to leakage currents, which falsify the measured charge result. Moreover, most direct conversion materials suffer from large residual signals that lead to temporal artifacts (ghost images) in an X-ray image sequence. A circuit is described, which senses the sensor's dark current including residual signals from previous exposures before the sensor is exposed (again) to X-ray, and freezes relevant circuit parameters at the end of the sensing phase in such way, that the dark current (leakage current and residual signal) can still be drained during exposure. Therefore, the charge pulses generated in the sensor due to X-ray exposure can be integrated without charges carried by the leakage current or residual signal, thus obtaining a more accurate estimate of the deposited X-ray energy.

Abstract: A method for providing information about a spatial gain distribution of a scintillator for a primary radiation is provided which does not require the irradiation of the scintillator with the primary radiation. The method comprises the step of irradiating the scintillator with a secondary radiation for generating an image of a spatial secondary gain distribution of the scintillator for said second radiation. The spatial secondary gain distribution image corresponds to an image of the spatial primary gain distribution for the primary radiation. In an embodiment of the invention, i.e. in an X-ray imaging device where the primary radiation is X-ray radiation, the invention provides for an accurate calibration of the X-ray detector without irradiating the X-ray detector with X-ray radiation. Rather, irradiation with UV radiation as the secondary radiation provides the desired spatial secondary gain distribution image which can be used for calibration.

Abstract: The invention relates to converter element (100) for a radiation detector, particularly for a Spectral CT scanner. The converter element (100) comprises at least two conversion cells (131) that are at least partially separated from each other by intermediate separation walls (135) which affect the spreading of electrical signals generated by incident radiation (X). The conversion cells (131) may particularly consist of a crystal of CdTe and/or CdZnTe. Said crystal is preferably grown by e.g. vapor deposition between preformed separation walls.

Abstract: The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.

Abstract: Systems and methods for data acquisition in computed tomography (CT) applications are provided. The systems and methods are particularly adapted for scanning and acquiring/processing data in connection with high-power cone-beam CT applications. The electron beam is moved/scanned along the anode surface to multiple focal positions. Data acquisition for a full projection at one focus position and one view angle is achieved by activating each focus position multiple times during the data acquisition for one angle of the gantry. The detector array and associated data processing system are adapted to rapidly switch between the different focus positions during the acquisitions for one view angle and to collect all data belonging to the same projection into the same data set. Adaptive electron optics are utilized to move/scan the electron beam along the anode surface to the various focus positions.

Abstract: According to an embodiment of the invention, a radiation detector device (10) for detecting a primary radiation (6) comprises a scintillator (12) which generates a converted primary radiation in response to incoming primary radiation (6) and a photo detector (14) for detecting the converted primary radiation. The radiation detector device (10) further comprises a secondary radiation source (20) for irradiating the scintillator (12) with a secondary radiation (22) which has a wavelength different from a wavelength of the first radiation (6) and which is capable of producing a spatially more uniform response of the scintillator (12) to primary radiation. In an embodiment of the invention, the radiation detector device (10) is an X-ray detector of an X-ray imaging apparatus where the primary radiation is X-ray radiation and the secondary radiation has a wavelength between 350 nm and 450 nm. According to an embodiment, the irradiation with the secondary radiation, e.g.

Abstract: A method for providing information about a spatial gain distribution of a scintillator for a primary radiation is provided which does not require the irradiation of the scintillator with the primary radiation. The method comprises the step of irradiating the scintillator with a secondary radiation for generating an image of a spatial secondary gain distribution of the scintillator for said second radiation. The spatial secondary gain distribution image corresponds to an image of the spatial primary gain distribution for the primary radiation. In an embodiment of the invention, i.e. in an X-rayimaging device where the primary radiation is X-rayradiation, the invention provides for an accurate calibration of the X-raydetector without irradiating the X-raydetector with X-rayradiation. Rather, irradiation with UV radiation as the secondary radiation provides the desired spatial secondary gain distribution image which can be used for calibration.