Abstract: The present disclosure provides compositions and methods that rapidly and selectively modify cells of the immune system to achieve therapeutic objectives. The methods can be practiced in vivo and any cell type that expresses a known marker can be targeted for a therapeutic objective.

Abstract: The present disclosure provides compositions and methods that rapidly and selectively modify cells of the immune system to achieve therapeutic objectives. The methods can be practiced in vivo and any cell type that expresses a known marker can be targeted for a therapeutic objective.

Abstract: Compositions and methods that rapidly and selectively modify hematopoietic stem cells (or cells derived therefrom) to achieve therapeutic objectives by providing for transient expression of nucleic acids are described. The transient expression leads to permanent therapeutic changes in the modified cells, referred to herein as “hit and run” effects.

Abstract: The present disclosure provides compositions and methods for the delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse. The compositions comprise (i) a structure comprising an injectable polymer or scaffold comprising pores; (ii) lymphocytes disposed within the structure, (iii) at least one lymphocyte-adhesion moiety associated with the structure; and (iv) at least one lymphocyte-activating moiety associated with the structure, and optionally an immune stimulant.

Abstract: Provided is an RF resource allocation device that distributes to a mobile terminal a communication setting notification including a communication setting to be used in a radio communication. The device includes an acquisition unit configured to acquire a measurement result or an estimation result of communication conditions at a plurality of positions; a generation unit configured to determine for each region the communication setting to be used by the mobile terminal in the radio communication based on the communication conditions, and to generate the communication setting notification including the communication setting for each region; and a transmission unit configured to transmit the communication setting notification to the mobile terminal The acquisition of the communication conditions by the acquisition unit and the generation of the communication setting notification by the generation unit are executed repeatedly at predetermined time intervals.

Abstract: The present disclosure provides compositions and methods for the delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse. The compositions comprise (i) a structure comprising an injectable polymer or scaffold comprising pores; (ii) lymphocytes disposed within the structure, (iii) at least one lymphocyte-adhesion moiety associated with the structure; and (iv) at least one lymphocyte-activating moiety associated with the structure, and optionally an immune stimulant.

Abstract: Compositions and methods that rapidly and selectively modify hematopoietic stem cells (or cells derived therefrom) to achieve therapeutic objectives by providing for transient expression of nucleic acids are described. The transient expression leads to permanent therapeutic changes in the modified cells, referred to herein as “hit and run” effects.

Abstract: The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.

Abstract: The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.

Abstract: A wireless communication apparatus includes a radar device; a communication device configured to communicate using at least a part of a frequency band that is used by the radar device; an acquirer configured to acquire a position of a target object using the radar device; a predictor configured to predict a trajectory of the target object from history of positions of the target object; and a controller configured to determine a communication start time with the target object based on a communication range of the communication device and the trajectory of the target object, and control the communication device so that data is transmitted to the target object at the determined communication start time using the communication device.

Abstract: Provided is an RF resource allocation device that distributes to a mobile terminal a communication setting notification including a communication setting to be used in a radio communication. The device includes an acquisition unit configured to acquire a measurement result or an estimation result of communication conditions at a plurality of positions; a generation unit configured to determine for each region the communication setting to be used by the mobile terminal in the radio communication based on the communication conditions, and to generate the communication setting notification including the communication setting for each region; and a transmission unit configured to transmit the communication setting notification to the mobile terminal The acquisition of the communication conditions by the acquisition unit and the generation of the communication setting notification by the generation unit are executed repeatedly at predetermined time intervals.

Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.

Abstract: A wireless communication apparatus includes a radar device; a communication device configured to communicate using at least a part of a frequency band that is used by the radar device; an acquirer configured to acquire a position of a target object using the radar device; a predictor configured to predict a trajectory of the target object from history of positions of the target object; and a controller configured to determine a communication start time with the target object based on a communication range of the communication device and the trajectory of the target object, and control the communication device so that data is transmitted to the target object at the determined communication start time using the communication device.

Abstract: Provided is an RF resource allocation device that distributes to a mobile terminal a communication setting notification including a communication setting to be used in a radio communication. The device includes an acquisition unit configured to acquire a measurement result or an estimation result of communication conditions at a plurality of positions; a generation unit configured to determine for each region the communication setting to be used by the mobile terminal in the radio communication based on the communication conditions, and to generate the communication setting notification including the communication setting for each region; and a transmission unit configured to transmit the communication setting notification to the mobile terminal The acquisition of the communication conditions by the acquisition unit and the generation of the communication setting notification by the generation unit are executed repeatedly at predetermined time intervals.

Abstract: The present disclosure provides compositions and methods that rapidly and selectively modify cells of the immune system to achieve therapeutic objectives. The methods can be practiced in vivo and any cell type that expresses a known marker can be targeted for a therapeutic objective.

Abstract: Compositions and methods that rapidly and selectively modify hematopoietic stem cells (or cells derived therefrom) to achieve therapeutic objectives by providing for transient expression of nucleic acids are described. The transient expression leads to permanent therapeutic changes in the modified cells, referred to herein as “hit and run” effects.

Abstract: Provided is an RF resource allocation device that distributes to a mobile terminal a communication setting notification including a communication setting to be used in a radio communication. The device includes an acquisition unit configured to acquire a measurement result or an estimation result of communication conditions at a plurality of positions; a generation unit configured to determine for each region the communication setting to be used by the mobile terminal in the radio communication based on the communication conditions, and to generate the communication setting notification including the communication setting for each region; and a transmission unit configured to transmit the communication setting notification to the mobile terminal The acquisition of the communication conditions by the acquisition unit and the generation of the communication setting notification by the generation unit are executed repeatedly at predetermined time intervals.

Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.

Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.

Abstract: The present disclosure provides compositions and methods that rapidly and selectively modify cells of the immune system to achieve therapeutic objectives. The methods can be practiced in vivo and any cell type that expresses a known marker can be targeted for a therapeutic objective. The present disclosure provides compositions and methods that rapidly and selectively modify cells of the immune system to achieve therapeutic objectives. The methods can be practiced in vivo and any cell type that expresses or is associated with a known marker can be targeted for a therapeutic objective by the modified cell.