Patents by Inventor Matthias Stephan

Matthias Stephan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for localized agent delivery
    Patent number: 9283184
    Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: March 15, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Matthias Stephan, Jaehyun Moon, Anna Bershteyn
  • COMPOSITIONS AND METHODS FOR DELIVERY OF IMMUNE CELLS TO TREAT UN-RESECTABLE OR NON-RESECTED TUMOR CELLS AND TUMOR RELAPSE
    Publication number: 20160008399
    Abstract: The present disclosure provides compositions and methods for the delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse. The compositions comprise (i) a structure comprising an injectable polymer or scaffold comprising pores; (ii) lymphocytes disposed within the structure, (iii) at least one lymphocyte-adhesion moiety associated with the structure; and (iv) at least one lymphocyte-activating moiety associated with the structure, and optionally an immune stimulant.
    Type: Application
    Filed: January 14, 2014
    Publication date: January 14, 2016
    Applicant: Fred Hutchinson Cancer Research Center
    Inventor: MATTHIAS STEPHAN
  • CONSTITUTIVE EXPRESSION OF COSTIMULATORY LIGANDS ON ADOPTIVELY TRANSFERRED T LYMPHOCYTES
    Publication number: 20160008398
    Abstract: The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
    Type: Application
    Filed: June 9, 2015
    Publication date: January 14, 2016
    Applicant: Memorial Sloan-Kettering Cancer Center
    Inventors: Michel Sadelain, Matthias Stephan
  • Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
    Patent number: 9220728
    Abstract: The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: December 29, 2015
    Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: Michel Sadelain, Matthias Stephan
  • METHODS AND COMPOSITIONS FOR LOCALIZED AGENT DELIVERY
    Publication number: 20140017170
    Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
    Type: Application
    Filed: June 5, 2013
    Publication date: January 16, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Matthias Stephan, Jaehyun Moon, Anna Bershteyn
  • CONSTITUTIVE EXPRESSION OF COSTIMULATORY LIGANDS ON ADOPTIVELY TRANSFERRED T LYMPHOCYTES
    Publication number: 20130121960
    Abstract: The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
    Type: Application
    Filed: August 27, 2012
    Publication date: May 16, 2013
    Applicant: Memorial Sloan-Kettering Cancer Center
    Inventors: Michel Sadelain, Matthias Stephan
  • Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
    Patent number: 8389282
    Abstract: The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: March 5, 2013
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Michel Sadelain, Matthias Stephan
  • Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
    Patent number: 8252592
    Abstract: The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: August 28, 2012
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Michel Sadelain, Matthias Stephan
  • METHODS AND COMPOSITIONS FOR LOCALIZED AGENT DELIVERY
    Publication number: 20110293705
    Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
    Type: Application
    Filed: November 24, 2009
    Publication date: December 1, 2011
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Matthias Stephan, Jaehyun Moon, Anna Bershteyn
  • CONSTITUTIVE EXPRESSION OF COSTIMULATORY LIGANDS ON ADOPTIVELY TRANSFERRED T LYMPHOCYTES
    Publication number: 20100178276
    Abstract: The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
    Type: Application
    Filed: March 31, 2008
    Publication date: July 15, 2010
    Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: Michel Sadelain, Matthias Stephan