Abstract: This disclosure concerns a cytometry system including a handling system that enables presentation of single cells to at least one laser source. The laser source is configured to deliver light to a cell within the cells in order to induce bond vibrations in the cellular DNA. The system further includes a detection facility that detects the signature of the bond vibrations, wherein the bond vibration signature is used to determine the folding or packing of the DNA.

Abstract: A method for determining a nonlinearity characteristic of a receiver path includes generating a set of N×M digital samples by repeating N times selecting an scaling factor from a set of N scaling factors, generating a version of a test signal, the version of the test signal corresponding to a test signal scaled by the respective scaling factor, processing the respective version of the test signal in at least a part of the receiver path to generate a respective processed signal, and storing M digital samples corresponding to the respective processed signal. Fourier-transformed data are generated using at least a portion of the set of N×M digital samples and a nonlinearity characteristic of the receiver path is determined based on the Fourier-transformed data.

Abstract: The disclosure relates to growing cells, directing cells to grow into specified cell types, genetically and physically manipulating cells, and addressing one or more individual cells within a mixed cell population. Aspects of the disclosure relate to vectors useful to induce developmental changes in cells, in which those vectors have a temporal component. Vectors of the disclosure encode a controllable, temporal series of events. Once the vectors are delivered into target cells, a series of discrete and different genetic events may be induced. The disclosed methods generally provide for the temporal encoding of multiplex genetic effectors in vector format for cell state transitions.

Abstract: A mobile apparatus for capturing an object space includes a frame and at least one single scanner mounted on the frame and a multiple scanner mounted on the frame above the single scanner. This multiple scanner has a plurality of emission units integrated in one component, a receiver for detecting reflected rays, and a scanning device for changing the emission directions of the signal beams of the emission units. Furthermore, the mobile apparatus has an evaluation device which is designed to generate and output in real time, at least from the reflected rays detected by the receiver, a graphical representation of those areas of the object space through which the mobile apparatus can be moved and/or has been moved. Finally, the mobile apparatus has a data interface designed to output data to a memory device for post-processing. A corresponding method for capturing an object space is also disclosed.

Abstract: Methods, systems, and computer program products are provided for monitoring a cell culture, utilizing a predictive model to improve cell culture processes, measuring cell dynamics of a cell culture, managing cell clusters in a cell culture system, and training a machine learning model for managing cell clusters in a cell culture system. In various embodiments, a cell culture may be maintained in a cell culture chamber. The cell culture may comprise one or more cell colonies. One or more properties of the cell culture may be measured. One or more perturbations may be applied to all or a portion of the cell culture. The one or more properties of the cell culture may be measured after applying the one or more perturbations. The one or more properties may be compared before and after the one or more perturbations. The cell culture may be managed based on the comparison.

Abstract: Technologies for assessing, quantifying and isolating sperm cell populations and/or subpopulations having specific genetic signatures are provided, as well as methods and systems to assess the efficacy of chromosomal differentiation processes. Compositions for identification and differentiation of X-chromosomes and Y-chromosomes in DNA are also provided.

Abstract: The holder for a center console, including a first fastening region for fastening to the vehicle body as well as a second fastening region for fastening to the center console, wherein the first fastening region and the second fastening region are connected by at least one arm extending in the Z-direction. The arm has a primary region with a first center axis and at least one secondary region with a second center axis which form relative to one another at least one bend point, which permits deformation of the primary region relative to the secondary region and thus a movement of the first fastening region relative to the second fastening region in the Z-direction.

Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.