Patents by Inventor Mattias Myrman

Mattias Myrman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060257327
    Abstract: The invention discloses a medical product for use in a treatment of respiratory disorders, and comprises a metered dose of a tiotropium dry powder formulation, directly loaded and sealed into a container made to act as a dry high barrier seal to prevent the capture and ingress of moisture into the tiotropium powder. The dose of tiotropium is further adapted for inhalation and the container is so tight that the efficacy of the dose when delivered is unaffected by moisture. In a further aspect of the invention a type of inhaler is illustrated, which may accept at least one sealed, moisture-tight container of a dose of tiotropium, to deliver the dose with a consistent fine particle dose, over the expected shelf life of the product.
    Type: Application
    Filed: June 8, 2006
    Publication date: November 16, 2006
    Inventors: Bernd Zierenberg, Holger Memmesheimer, Christine Lunkenheimer, Sven Calander, Alf Niemi, Thomas Nilsson, Mattias Myrman
  • Publication number: 20060239933
    Abstract: A medical product is disclosed. The medical product contains an accurately metered dose of at least one GLP medicament intended for pulmonary inhalation put into a moisture-tight, high barrier seal container. The medical product optionally also contains a dose of insulin. The container is adapted for application into a dry powder inhaler. The dose loaded in the container is intended for a prolonged delivery by inhalation to the deep lung where the active ingredients are absorbed into the system. Optionally the medical product also may comprise at least one biologically acceptable excipient.
    Type: Application
    Filed: November 15, 2005
    Publication date: October 26, 2006
    Applicant: MEDERIO AG
    Inventors: Thomas Nilsson, Sven Calander, Alf Niemi, Claes Friberg, Lars Kax, Mattias Myrman
  • Publication number: 20060120969
    Abstract: A medical product containing an accurately metered dose of a GLP-1 medicament intended for pulmonary inhalation put into a moisture-tight, high barrier seal container. The medical product optionally also contains a dose of insulin. The container is preferably adapted for application into a dry powder inhaler. The dose loaded in the container is intended for a prolonged delivery by inhalation to the deep lung where the active ingredients are absorbed into the system. Optionally the medical product also may comprise at least one biologically acceptable excipient.
    Type: Application
    Filed: February 4, 2005
    Publication date: June 8, 2006
    Applicant: Microdrug AG
    Inventors: Thomas Nilsson, Sven Calander, Alf Niemi, Claes Friberg, Lars Kax, Mattias Myrman
  • Publication number: 20060067911
    Abstract: The invention discloses a metered medication dose of a dry powder protein medicament, particularly a peptide medicament, intended for inhalation by use of an adapted dry powder inhaler. An active peptide agent is presented in a pure, natural, crystalline, micronized, dry powder form. A dose comprises at least one such peptide powder and may optionally comprise at least one biologically acceptable excipient in dry powder form. The dose does not include any substances that are intended to change one, some or all properties of the at least one peptide with an object of improving the stability or systemic absorption of the active peptide or peptides deposited.
    Type: Application
    Filed: April 22, 2005
    Publication date: March 30, 2006
    Applicant: MEDERIO AG
    Inventors: Thomas Nilsson, Claes Friberg, Lars Kax, Alf Niemi, Mattias Myrman, Sven Calander
  • Publication number: 20060021616
    Abstract: A dry powder inhaler device (DPI) is disclosed. When a user activates the inhaler, the DPI is capable of delivering a dry powder dose directly from a medicament container, loaded into the DPI. A method is also disclosed for delivering a dry powder medicament dose directly from a container to a user of a DPI, whereby a sealing foil of the container is being slit open concurrently with aerosolizing and entraining of the powder in the dose into the inhaled air.
    Type: Application
    Filed: June 6, 2005
    Publication date: February 2, 2006
    Applicant: MEDERIO AG
    Inventor: Mattias Myrman
  • Publication number: 20060000473
    Abstract: A method and a device for making a metered dry powder medication dose, enclosed in a dose container, accessible for inhalation with a minimum of exposure to ambient atmosphere.
    Type: Application
    Filed: June 6, 2005
    Publication date: January 5, 2006
    Applicant: MEDERIO AG
    Inventor: Mattias Myrman
  • Publication number: 20050279356
    Abstract: A medicament container for carrying a metered, finely divided, dry powder medication dose is disclosed. The medicament container, which is intended for administration by a dry powder inhaler device, constitutes a pod presents a bottom surface acting as a dose bed adapted for receiving a metered medication dose. The metered dose, carried by the pod, is protected from foreign matter, particularly moisture, after a sealing of the pod with a high barrier seal foil, which transforms the pod into a high barrier container. Furthermore the pod is formed such that the pod sealing foil can be slit open from a point of penetration at a first pod end to a point of exit at a second pod end by a cutter set in motion relative to the pod.
    Type: Application
    Filed: July 26, 2004
    Publication date: December 22, 2005
    Applicant: Microdrug AG
    Inventors: Claes Friberg, Lars Kax, Mattias Myrman
  • Publication number: 20050121026
    Abstract: A method for administration and preparation of pharmaceutical dry powder doses are disclosed. The metered dry powder doses are formed from a finely divided dry powder of an selected anticholinergic agent to be used in a dry powder inhaler device. The metered dry powder medicinal dose is arranged as a medicinally effective quantity of the selected medicament onto a dose bed and moisture-tight sealed by using a high barrier seal, for introduction into an inhaler device provided with an Air-razor device for obtaining a fine particle fraction, FPF, of at least 30-50% of delivered powder mass when suction through the inhaler is applied, whereby the dose is delivered to and deposited in the lung of the user during a single inhalation effort.
    Type: Application
    Filed: December 8, 2003
    Publication date: June 9, 2005
    Inventors: Thomas Nilsson, Mattias Myrman, Sven Calander, Alf Niemi
  • Publication number: 20050121027
    Abstract: A medical product suitable for storing and delivering a pre-metered dose of tiotropium, devices containing the same, and methods of using the same.
    Type: Application
    Filed: April 29, 2004
    Publication date: June 9, 2005
    Applicant: Microdrug AG
    Inventors: Thomas Nilsson, Mattias Myrman, Sven Calander, Alf Niemi
  • Publication number: 20050124644
    Abstract: The invention discloses a medical product for use in a treatment of respiratory disorders, and comprises a metered dose of a tiotropium dry powder formulation, directly loaded and sealed into a container made to act as a dry high barrier seal to prevent the capture and ingress of moisture into the tiotropium powder. The dose of tiotropium is further adapted for inhalation and the container is so tight that the efficacy of the dose when delivered is unaffected by moisture. In a further aspect of the invention a type of inhaler is illustrated, which may accept at least one sealed, moisture-tight container of a dose of tiotropium, to deliver the dose with a consistent fine particle dose, over the expected shelf life of the product.
    Type: Application
    Filed: December 8, 2003
    Publication date: June 9, 2005
    Inventors: Thomas Nilsson, Mattias Myrman, Sven Calander, Alf Niemi
  • Publication number: 20050121032
    Abstract: The invention discloses a dry powder inhaler for use in a treatment of respiratory disorders.
    Type: Application
    Filed: September 3, 2004
    Publication date: June 9, 2005
    Applicant: Microdrug AG
    Inventors: Thomas Nilsson, Mattias Myrman, Sven Calander, Alf Niemi
  • Publication number: 20050123486
    Abstract: The invention discloses a medical product that may be used in a treatment of respiratory disorders.
    Type: Application
    Filed: August 19, 2004
    Publication date: June 9, 2005
    Applicant: Microdrug AG
    Inventors: Thomas Nilsson, Mattias Myrman, Sven Calander, Alf Niemi
  • Patent number: 6892727
    Abstract: A device and an arrangement are disclosed, which create a powder Air-razor, which into an inhalation air volume de-aggregates and disperses a finely divided medication powder. The powder is generally loaded onto a dosing member intended for use with an inhaler. By sucking air through a mouthpiece connected to a nozzle, particles of the load of powder are gradually de-aggregated, dispersed and continuously released into the sucked air during a defined interval. The gradual de-aggregation and dispersal of the medication powder is generated by a relative motion introduced between the nozzle and the dosing member. The powder is generally loaded onto a larger area than the area of the air nozzle inlet. The nozzle may be positioned outside the dose area until an air stream has begun to flow into the nozzle by suction of air in an inhaling operation.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: May 17, 2005
    Assignee: Mederio AG
    Inventor: Mattias Myrman
  • Patent number: 6881398
    Abstract: A therapeutic dry powder preparation and a method of administering such a preparation are disclosed for effectively de-aggregating and dispersing into air a dose of medication powder in an administration the dose to a user. The present dry powder preparation and method do not require other sources of energy besides the power of an inhalation effort by a user to produce a very high degree of de-aggregation and efficient dispersal into air of the dry powder medication dose. Utilizing an effort of sucking air through a nozzle, the particles of the therapeutic powder dose, made available to the nozzle, are gradually de-aggregated and dispersed into a stream of air entering the nozzle.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: April 19, 2005
    Assignee: Microdrug AG
    Inventors: Mattias Myrman, Per-Gunnar Nilsson
  • Publication number: 20050063911
    Abstract: The present invention discloses pharmaceutical dry powder combined doses for the administration by inhalation of metered dry powder combined doses of finely divided dry medication powders. Formoterol and an anticholinergic agent are selected medicaments for forming the combined doses. Metered dry powder medicinal combined doses comprising separately metered deposits of medicinally suitable quantities of each of the selected medicaments are prepared, in which the sum of the metered deposits constitutes the metered quantities of powder of the combined doses and the medicinal combined doses are introduced into an adapted inhaler device for a generally simultaneous or sequential delivery of the medicinal combined doses during the course of a single inhalation by a user, such that each one of the delivered medicinal combined doses is composed of a high proportion of de-aggregated fine particles of the selected medicament or medicaments, whereby a desired therapeutic or treating effect to the user is achieved.
    Type: Application
    Filed: June 21, 2004
    Publication date: March 24, 2005
    Applicant: Microdrug AG
    Inventors: Thomas Nilsson, Mattias Myrman, Claes Friberg, Sven Calander
  • Publication number: 20050053553
    Abstract: The present invention discloses a method and pharmaceutical dry powder combined doses for administration by inhalation of metered dry powder combined doses of finely divided dry medication doses. Formoterol and fluticasone are selected medicaments for forming the combined doses. Metered dry powder medicinal combined doses comprising separately metered deposits of medicinally effective quantities of each of the selected medicaments are prepared, in which the sum of the metered deposits constitutes the metered quantities of powder of the combined doses and the medicinal combined doses are introduced into an adapted inhaler device for a generally simultaneous or sequential prolonged delivery of the medicinal combined doses during the course of a single inhalation by a user, such that each one of the administered medicinal combined doses is composed of a high proportion of de-aggregated fine particles of the selected medicament or medicaments and directed to a selected location in the lungs.
    Type: Application
    Filed: November 10, 2003
    Publication date: March 10, 2005
    Inventors: Thomas Nilsson, Mattias Myrman, Claes Friberg, Sven Calander
  • Publication number: 20050042174
    Abstract: A method and pharmaceutical dry powder combination of doses for the prophylaxis or treatment of a respiratory disorder in a user by inhalation of metered dry powder combinations of doses of finely divided dry medication powders. Medicaments for forming a combination of doses are selected from a group of beta2-agonists, a group of anticholinergic agents and a group of anti-inflammatory corticosteroids. Metered dry powder medicinal combinations of doses comprising separately metered deposits of medicinally suitable quantities of each of the selected medicaments are prepared. The medicinal combination of doses are introduced into an adapted inhaler device for a generally simultaneous or sequential delivery during the course of a single inhalation by a user, such that each one of the delivered medicinal combination of doses is composed of a high proportion of de-aggregated fine particles of the selected medicament or medicaments.
    Type: Application
    Filed: June 21, 2004
    Publication date: February 24, 2005
    Applicant: Microdrug AG
    Inventors: Thomas Nilsson, Mattias Myrman, Claes Friberg, Sven Calander
  • Publication number: 20050042175
    Abstract: The present invention discloses pharmaceutical dry powder combined doses for administration by inhalation of metered dry powder combined doses of finely divided dry medication doses. Formoterol and budesonide are selected medicaments for forming the combined doses. Metered dry powder medicinal combined doses comprising separately metered deposits of medicinally effective quantities of each of the selected medicaments are prepared, in which the sum of the metered deposits constitutes the metered quantities of powder of the combined doses and the medicinal combined doses are introduced into an adapted inhaler device for a generally simultaneous or sequential prolonged delivery of the medicinal combined doses during the course of a single inhalation by a user, such that each one of the administered medicinal combined doses is composed of a high proportion of de-aggregated fine particles of the selected medicament or medicaments and directed to a selected location in the lungs of a user.
    Type: Application
    Filed: June 21, 2004
    Publication date: February 24, 2005
    Applicant: Microdrug AG
    Inventors: Thomas Nilsson, Mattias Myrman, Claes Friberg, Sven Calander
  • Patent number: 6840239
    Abstract: A method based on an Air-razor tool is disclosed thereby providing de-aggregation and dispersal into air of a dose of finely divided medication powder. In sucking air through a nozzle, particles of a powder dose made available to the nozzle, are gradually de-aggregated and dispersed into a stream of air entering the nozzle. The gradual de-aggregation or dispersal is produced by a relative motion introduced between the nozzle and the dose. In a preferred embodiment, the powder is deposited onto a substrate, occupying a larger area than the area of the nozzle inlet. The nozzle is preferably positioned outside the powder area, not accessing the powder in its relative motion until a created air stream entering the nozzle, exceeds a threshold flow velocity.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: January 11, 2005
    Assignee: Microdrug AG
    Inventor: Mattias Myrman
  • Publication number: 20040258624
    Abstract: The present invention discloses a method and a pharmaceutical dry powder combined dose for the prophylaxis or treatment of a respiratory disorder in a mammalian host by inhalation of a metered dry powder combined dose of finely divided dry medication powders. At least one dry powder medicament is selected from a first group of bronchodilating medicaments and at least one dry powder medicament from a second group of anti-inflammatory medicaments.
    Type: Application
    Filed: June 26, 2003
    Publication date: December 23, 2004
    Applicant: Microdrug AG
    Inventors: Thomas Nilsson, Mattias Myrman, Claes Friberg, Sven Calander