Mattias Myrman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
Abstract: A method as well as a therapeutic metered combined dose are disclosed for a combined administration of medicinal dry powders. A metered medicinal dry powder combined dosage comprising at least two medicaments of separate dry powder formulations is prepared, whereby the metered powder quantity per medicament is deposited in a dose forming step creating the medicinal combined dose. The deposits of the at least two medicaments are suitably kept separated from each other, such that the medicaments cannot detrimentally interact after forming of the combined dose, and the medicinal combined dose is introduced into an inhaler device for a delivery of the powder dose during the course of a single inhalation.
June 26, 2003
December 23, 2004
Thomas Nilsson, Mattias Myrman, Claes Friberg, Sven Calander
Abstract: A device is disclosed for controlling the duration of an administration of a prescribed dose of dry powder to a user's lung when inhaling the powder by use of a dry powder inhaler (DPI). The present device controls the speed of a moving cassette (4) carrying medical powder doses to one by one be administered by the DPI to a user. Generally the dose is pre-metered and applied to the cassette in the form of a strip (31) or a series of spots of ready-prepared powder. The present device using the airbrake arrangement (22) prolongs the time during which the pre-metered powder dose is released to the inhalation air. Adjustment means of the airbrake arrangement (22) define leakage of air (36) and thereby motion speed of a spring-loaded cassette (4). During the motion of the cassette the powder dose is sucked from the prepared dose powder strip onto the cassette (4) by a nozzle (1) connected to a mouthpiece used for inhaling medical powder from the dry powder inhaler.
Abstract: A foil-cutting device is disclosed for opening a foil protecting a dose of medical power carried by a dosing cassette or the like for an inhaler device. The dosing cassette will in a typical embodiment carry a number of prepared doses (31), which for protection of the medical powder are covered by a metallic or plastic foil (24). The foil-cutter device of the present invention provides a tool (11) for accessing a selected sealed dose of medical powder of the cassette during an inhalation process using a dry powder inhaler (DPI). When a user inhales through the DPI the foil-cutter opens the foil (24) for access to a pre-metered powder dose (31). The foil-cutter arrangement ensures that no access is permitted to the pre-metered dose during any other circumstances. Particularly the present invention is adapted to be applied in an inventive continuous inhaler prolonging the release of a powder dose during the inhalation of the medical powder.
Abstract: A device and an arrangement are disclosed, which create a powder Air-razor, which into an inhalation air volume de-aggregates and disperses a finely divided medication powder. The powder is generally loaded onto a dosing member intended for use with an inhaler. By sucking air through a mouthpiece connected to a nozzle, particles of the load of powder are gradually de-aggregated, dispersed and continuously released into the sucked air during a defined interval. The gradual de-aggregation and dispersal of the medication powder is generated by a relative motion introduced between the nozzle and the dosing member. The powder is generally loaded onto a larger area than the area of the air nozzle inlet. The nozzle may be positioned outside the dose area until an air stream has begun to flow into the nozzle by suction of air in an inhaling operation.
Abstract: A method based on an Air-razor tool is disclosed thereby providing de-aggregation and dispersal into air of a dose of finely divided medication powder. In sucking air through a nozzle, particles of a powder dose made available to the nozzle, are gradually de-aggregated and dispersed into a stream of air entering the nozzle. The gradual de-aggregation or dispersal is produced by a relative motion introduced between the nozzle and the dose. In a preferred embodiment, the powder is deposited onto a substrate, occupying a larger area than the area of the nozzle inlet. The nozzle is preferably positioned outside the powder area, not accessing the powder in its relative motion until a created air stream entering the nozzle, exceeds a threshold flow velocity.
Abstract: A therapeutic dry powder preparation and a method of administering such a preparation are disclosed for effectively de-aggregating and dispersing into air a dose of medication powder in an administration the dose to a user. The present dry powder preparation and method do not require other sources of energy besides the power of an inhalation effort by a user to produce a very high degree of de-aggregation and efficient dispersal into air of the dry powder medication dose. Utilizing an effort of sucking air through a nozzle, the particles of the therapeutic powder dose, made available to the nozzle, are gradually de-aggregated and dispersed into a stream of air entering the nozzle.
Abstract: An arrangement is disclosed for, in connection to an inhalation operation, opening and closing an air inlet of a dry powder inhaler device (DPI) provided with a pre-metered dosing member (4). The arrangement requires a certain well-defined minimum pressure differential between a surrounding atmosphere and the airways of the inhaling person to open the inlet for outside air to enter into the interior of the DPI. The arrangement controlling the opening and closing of the air inlet presents a biased flap connected to a biased catch mechanism. The biased flap (16) closes the air inlets (23) of the DPI to the atmosphere by the force exerted by a compression spring (13), which acts on the flap through a mechanism of levers. In order to open the flap a force Fp bigger than the closing force Fc of the spring and lever mechanism must be applied. The necessary force ensues from the pressure differential across the flap resulting when sucking the mouthpiece of the DPI to a certain degree.
Abstract: An continuous dry powder inhaler arrangement is disclosed, the arrangement being provided with electrostatically dosed medical powder onto an exchangeable dosing member like a cassette or the like for respiratory administration of medicaments into the deep or upper lung airways. The inhaler presents a compact integrated device (8) with a case having a sliding lid (17), which can be set in an open position exposing a mouthpiece (19) or in a closed position. The arrangement further provides dose (18b/18c) counters and a cassette counter (34). In the state with open lid (17) the device is ready to deliver a prepared pre-metered dose of medical powder upon an inhalation via the exposed mouthpiece (19). Medical drugs are in advance dosed as medical powder and carried by an exchangeable dosing means and constitute dry powder substances or dry powder medical formulations prepared for continuous dosing during a preset period of operation.
Abstract: An interface arrangement is disclosed for ensuring proper dosing as well as achieving a safe operation and handling of a dry powder inhaler (DPI) used for administration of a powder to be inhaled. The interface of the present invention primarily handles the loading of a cassette (4) carrying pre-metered doses into the dry powder inhaler (8). An important characteristic is that the interface by utilizing a particular coding prevents a user from loading a cassette not containing the proper powder. Additionally the interface informs a user when a new mouthpiece has to be replaced after being used for a pre-defined number of inhalation operations. Additionally the interface informs a user when a present cassette has delivered its last dose and should be exchanged. Also information on the number of further cassettes already utilized will control that another cassette still is permitted to be loaded.
October 12, 2000
Date of Patent:
March 26, 2002
Mattias Myrman, Michael Strehl, Herbert Grässl