Patents by Inventor Maurizio Botta

Maurizio Botta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral compounds and use thereof
    Patent number: 11814366
    Abstract: The present invention relates to compounds of formula (I), their use as medicaments, in particular as broad spectrum antiviral agents, their combination with a further antiviral agent and relative pharmaceutical compositions. In particular, the compounds of the invention are useful in the treatment of a disease caused by an enveloped virus.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: November 14, 2023
    Assignee: UNIVERSITA DEGLI STUDI DI SIENA
    Inventors: Maurizio Botta, Filippo Canducci, Valeria Cagno, David Lembo, Cristina Tintori, Annalaura Brai, Nastasja Palombi
  • Use of DDX3 inhibitors as antiproliferative agents
    Patent number: 11000512
    Abstract: The present invention refers to compounds of formula I or II endowed with DDX3 inhibitory activity, relative pharmaceutical compositions and their use as antihyperproliferative agents. (I) or (II).
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: May 11, 2021
    Assignee: AZIENDA OSPEDALIERA UNIVERSITARIA SENESE
    Inventors: Annalaura Brai, Maurizio Botta, Cristina Tintori, Giovanni Maga
  • ANTIVIRAL COMPOUNDS AND USE THEREOF
    Publication number: 20210070737
    Abstract: The present invention relates to compounds of formula (I), their use as medicaments, in particular as broad spectrum antiviral agents, their combination with a further antiviral agent and relative pharmaceutical compositions. In particular, the compounds of the invention are useful in the treatment of a disease caused by an enveloped virus.
    Type: Application
    Filed: March 18, 2019
    Publication date: March 11, 2021
    Applicant: UNIVERSITA DEGLE STUDI DI SIENA
    Inventors: Maurizio BOTTA, Filippo CANDUCCI, Valeria CAGNO, David LEMBO, Cristina TINTORI, Annalaura BRAI, Nastaja PALOMBI
  • Human helicase DDX3 inhibitors as therapeutic agents
    Patent number: 10941121
    Abstract: The present invention refers to compounds endowed with RNA helicase DDX3 inhibitory activity of formula I and II and their therapeutic use, in particular for the treatment of viral diseases.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: March 9, 2021
    Assignee: AZIENDA OSPEDALIERA UNIVERSITARIA SENESE
    Inventors: Andreas Meyerhans, Miguel Angel Martinez De La Sierra, Annalaura Brai, Roberta Fazi, Cristina Tintori, Maurizio Botta, Jose Este-Araque, Javier Martinez
  • HUMAN HELICASE DDX3 INHIBITORS AS THERAPEUTIC AGENTS
    Publication number: 20200140398
    Abstract: The present invention refers to compounds endowed with RNA helicase DDX3 inhibitory activity of formula I and II and their therapeutic use, in particular for the treatment of viral diseases.
    Type: Application
    Filed: January 6, 2020
    Publication date: May 7, 2020
    Applicant: AZIENDA OSPEDALIERA UNIVERSITARIA SENESE
    Inventors: Andreas MEYERHANS, Miguel-Angel MARTINEZ DE LA SIERRA, Annalaura BRAI, Roberta FAZI, Cristina TINTORI, Maurizio BOTTA, Jose-Este ARAQUE, Javier MARTINEZ
  • USE OF DDX3 INHIBITORS AS ANTIPROLIFERATIVE AGENTS
    Publication number: 20190099403
    Abstract: The present invention refers to compounds of formula I or II endowed with DDX3 inhibitory activity, relative pharmaceutical compositions and their use as antihyperproliferative agents.
    Type: Application
    Filed: March 23, 2017
    Publication date: April 4, 2019
    Applicant: AZIENDA OSPEDALIERA UNIVERSITARIA SENRESE
    Inventors: Annalaura BRAI, Maurizio BOTTA, Cristina TINTPRO, Glovanni MAGA
  • Multitarget hedgehog pathway inhibitors and uses thereof
    Patent number: 10093642
    Abstract: The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: October 9, 2018
    Assignees: UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA”, UNIVERSITA DEGLI STUDI DI SIENA
    Inventors: Bruno Botta, Alberto Gulino, Maurizio Botta, Mattia Mori, Lucia Di Marcotullio, Paola Infante, Francesca Ghirga, Sara Toscano, Cinzia Ingallina, Romina Alfonsi
  • Macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors
    Patent number: 10071975
    Abstract: The present invention relates to macrocyclic amidinourea derivatives of formula 8, methods of preparation and uses thereof, pharmaceutical compositions in particular to be used as chitinase inhibitors in the treatment of a fungal infection.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: September 11, 2018
    Assignee: CYGNET BIOSCIENCES B.V.
    Inventors: Stefania Sanfilippo, Brunella Posteraro, Maurizio Sanguinetti, Maurizio Botta, Giorgio Maccari, Filomena De Luca, Jean-Denis Docquier, Davide Deodato
  • COMPOUNDS AND USES THEREOF
    Publication number: 20180186796
    Abstract: The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine derivatives of formula I and IV able to target the Src family kinases (SFKs) such as Src, Fyn and Hck tyrosine kinases as well as Abl tyrosine kinase and uses and method of preparation thereof. In particular, the compounds of the invention are for use in the treatment and/or prevention of cancer, such as neuroblastoma (NB) or glioblastoma multiforme (GBM) or for use in the treatment and/or prevention of neurodegenerative diseases such as taupathies.
    Type: Application
    Filed: October 29, 2015
    Publication date: July 5, 2018
    Applicant: LEAD DISCOVERY SIENA S.R.L.
    Inventors: Maurizio BOTTA, Adriano ANGELUCCI, Elena DREASSI, Silvia SCHENONE, Cristina TINTORI, Giulia VIGNAROLI
  • Linear guanidine derivatives, methods of preparation and uses thereof
    Patent number: 10004702
    Abstract: The present invention relates to linear guanidine derivatives, methods of preparation, uses and pharmaceutical compositions thereof. The compounds of Formulas 1 or 2 exhibit high antimicrobial activity against Gram positive and Gram negative bacteria.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: June 26, 2018
    Assignee: LEAD DISCOVERY SIENA S.R.L.
    Inventors: Maurizio Botta, Giorgio Maccari, Stefania Sanfilippo, Filomena De Luca, Jean-Denis Docquier, Davide Deodato
  • HUMAN HELICASE DDX3 INHIBITORS AS THERAPEUTIC AGENTS
    Publication number: 20180016243
    Abstract: The present invention refers to compounds endowed with RNA helicase DDX3 inhibitory activity of formula I and II and their therapeutic use, in particular for the treatment of viral diseases.
    Type: Application
    Filed: February 12, 2016
    Publication date: January 18, 2018
    Inventors: Andreas MEYERHANS, Miguel-Angel MARTINEZ DE LA SIERRA, Annalaura BRAI, Roberta FAZI, Cristina TINTORI, Maurizio BOTTA, Jose-Este ARAQUE, Javier MARTINEZ
  • LINEAR GUANIDINE DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF
    Publication number: 20170304235
    Abstract: The present invention relates to linear guanidine derivatives, methods of preparation, uses and pharmaceutical compositions thereof. The compounds of Formulas 1 or 2 exhibit high antimicrobial activity against Gram positive and Gram negative bacteria.
    Type: Application
    Filed: October 9, 2015
    Publication date: October 26, 2017
    Applicant: LEAD DISCOVERY SIENA S.R.L.
    Inventors: Maurizio BOTTA, Giorgio MACCARI, Stefania SANFILIPPO, Filomena DE LUCA, Jean-Denis DOCQUIER, Davide DEODATO
  • MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF
    Publication number: 20160368886
    Abstract: The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).
    Type: Application
    Filed: June 25, 2014
    Publication date: December 22, 2016
    Applicant: Universita' Degli Studi di Siena
    Inventors: Bruno BOTTA, Alberto GULINO, Maurizio BOTTA, Mattia MORI, Lucia DI MARCOTULLIO, Paola INFANTE, Francesca GHIRGA, Sara TOSCANO, Cinzia INGALLINA, Romina ALFONSI
  • NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS
    Publication number: 20160137617
    Abstract: The present invention relates to macrocyclic amidinourea derivatives of formula 8, methods of preparation and uses thereof, pharmaceutical compositions in particular to be used as chitinase inhibitors in the treatment of a fungal infection.
    Type: Application
    Filed: June 18, 2014
    Publication date: May 19, 2016
    Inventors: Stefania SANFILIPPO, Brunella POSTERARO, Maurizio SANGUINETTI, Maurizio BOTTA, Giorgio MACCARI, Filomena DE LUCA, Jean-Denis DOCQUIER, Davide DEODATO
  • Non peptidic 14-3-3 inhibitors and the use thereof
    Patent number: 8895600
    Abstract: The present invention refers to compounds with inhibitory activity against 14-3-3 proteins and their use in the treatment of tumors, in particular chronic myeloid leukemia. The invention also provides methods for the identification of 14-3-3 protein inhibitors.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: November 25, 2014
    Assignee: Università degli Studi di Siena
    Inventors: Maurizio Botta, Valentina Corradi, Federico Falchi, Manuela Mancini, Maria Alessandra Santucci
  • Linear and cyclic guanidine derivatives, method of preparation and uses thereof
    Patent number: 8685953
    Abstract: The present invention relates to linear and cyclic guanidine derivatives, method of preparation and uses thereof, pharmaceutical compositions to be used as antifungal agents, in particular against Candida species.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: April 1, 2014
    Assignee: Universita Degli Studi Di Siena
    Inventors: Maurizio Botta, Francesco Raffi, Paolo Visca
  • NON PEPTIDIC 14-3-3 INHIBITORS AND THE USE THEREOF
    Publication number: 20130203831
    Abstract: The present invention refers to compounds with inhibitory activity against 14-3-3 proteins and their use in the treatment of tumors, in particular chronic myeloid leukemia. The invention also provides methods for the identification of 14-3-3 protein inhibitors.
    Type: Application
    Filed: August 9, 2012
    Publication date: August 8, 2013
    Applicant: UNIVERSITÀ DEGLI STUDI DI SIENA
    Inventors: Maurizio BOTTA, Valentina CORRADI, Federico FALCHI, Manuela MANCINI, Maria Alessandra SANTUCCI
  • 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof
    Patent number: 8466164
    Abstract: The present invention relates to a compound 4-substituted derivative of pyrazolo[3,4-d]pyrimidine or of pyrrolo[2,3-d]pyrimidine having the formula (I) and uses thereof, in particular for the treatment of bone related diseases and tumors.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: June 18, 2013
    Assignee: Universita degli Studi di Siena
    Inventors: Silvia Schenone, Francesco Bondavalli, Olga Bruno, Maurizio Botta, Fabrizio Manetti, Marco Radi, Alessandra Santucci, Giovanni Maga, Mauro Bologna, Adriano Angelucci, Annalisa Santucci, Adriano Spreafico, Fabio Carraro, Jurgen Borlak
  • Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof and intermediates thereto
    Patent number: 8304410
    Abstract: The present invention relates to compounds having formula 3 as well as the synthesis, intermediates and methods of using the same.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: November 6, 2012
    Assignees: Università degli Studi di Roma “La Sapienza”, Università degli Studi di Siena
    Inventors: Mariangela Biava, Giulio Cesare Porretta, Raffaello Pompei, Maurizio Botta, Fabrizio Manetti, Alessandro De Logu
  • COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF
    Publication number: 20120202814
    Abstract: The present invention relates to the medical use of the compound of formula 1, 2, 3 or 4:
    Type: Application
    Filed: October 4, 2010
    Publication date: August 9, 2012
    Applicants: UNIVERSITÀ DEGLI STUDI DI SIENA, CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Marco Radi, Maurizio Botta, Federico Falchi, Giovanni Maga, Fausto Baldanti, Stefania Paolucci