Patents by Inventor Maurizio Botta

Maurizio Botta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine, synthesis process and uses thereof
    Patent number: 8012970
    Abstract: The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine (BM212). The invention concerns the use of the described compounds as antitubercular agents having high activity and low toxicity and process to obtain intermediates and final compounds.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: September 6, 2011
    Assignee: Universta' Degli Studi di Siena
    Inventors: Mariangela Biava, Fabrizio Manetti, Delia Deidda, Raffaello Pompei, Maurizio Botta, Giulio Cesare Porretta
  • Derivatives of 1--4-methylpiperazine, synthesis process and uses thereof
    Publication number: 20110144109
    Abstract: The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine (BM212). The invention concerns the use of the described compounds as antitubercular agents having high activity and low toxicity and process to obtain intermediates and final compounds.
    Type: Application
    Filed: February 23, 2011
    Publication date: June 16, 2011
    Inventors: Mariangela BIAVA, Fabrizio MANETTI, Delia DEIDDA, Raffaello POMPEI, Maurizio BOTTA, Giulio Cesare PORRETTA
  • Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl] methyl}-4-methylpiperazine, synthesis process and uses thereof
    Patent number: 7910581
    Abstract: The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine (BM212). The invention concerns the use of the described compounds as antitubercular agents having high activity and low toxicity and process to obtain intermediates and final compounds.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: March 22, 2011
    Inventors: Mariangela Biava, Fabrizio Manetti, Delia Deidda, Raffaello Pompei, Maurizio Botta, Giulio Cesare Porretta
  • LINEAR AND CYCLIC GUANIDINE DERIVATIVES, METHOD OF PREPARATION AND USES THEREOF
    Publication number: 20110039854
    Abstract: The present invention relates to linear and cyclic guanidine derivatives, method of preparation and uses thereof, pharmaceutical compositions to be used as antifungal agents, in particular against Candida species.
    Type: Application
    Filed: March 12, 2009
    Publication date: February 17, 2011
    Applicant: UNIVERSITÀ DEGLI STUDI DI SIENA
    Inventors: Maurizio Botta, Francesco Raffi, Paolo Visca
  • Spiro Compounds Useful as Antagonists of the H1 Receptor
    Publication number: 20100311734
    Abstract: The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, for treating diseases and conditions of the central nervous system (CNS), in particular sleep disorders.
    Type: Application
    Filed: July 24, 2008
    Publication date: December 9, 2010
    Inventors: Maurizio Botta, Emiliano Castiglioni, Romano Di Fabio, Raffaella Spinosa, Andrea Togninelli
  • 6-VINYL PYRIMIDINE AND PYRIMIDINONE DERIVATIVES AND THE USE THEREOF
    Publication number: 20100292260
    Abstract: The invention relates to 6-vinyl pyrimidine pyrimidinone derivatives and the use thereof as medicaments in particular for the treatment of HTV infections, the use thereof for preparing pharmaceutical compositions and methods for the preparation thereof.
    Type: Application
    Filed: October 13, 2006
    Publication date: November 18, 2010
    Applicant: UNIVERSITA DEGLI STUDI DE SIENA
    Inventors: Maurizio Botta, Federico Corelli, Elena Petricci, Marco Radi, Giovanni Maga, Jose A. Este, Antonello Mai
  • NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-D PYRIMIDINE AND PYRROLO[2,3-D]PYRIMIDINE AND USES THEREOF
    Publication number: 20100249152
    Abstract: The present invention relates to a compound 4-substituted derivative of pyrazolo[3,4-d]pyrimidine or of pyrrolo[2,3-d]pyrimidine having the formula (I) and uses thereof, in particular for the treatment of bone related diseases and tumours.
    Type: Application
    Filed: September 12, 2008
    Publication date: September 30, 2010
    Applicant: UNIVERSITA DEGLI STUDI DI SIENA
    Inventors: Silvia Schenone, Francesco Bondavalli, Olga Bruno, Maurizio Botta, Fabrizio Manetti, Marco Radi, Alessandra Santucci, Giovanni Maga, Mauro Bologna, Adriano Angelucci, Annalisa Santucci, Adriano Spreafico, Fabio Carraro, Jurgen Borlak
  • PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF AND INTERMEDIATES THERETO
    Publication number: 20100197672
    Abstract: The present invention relates to a compound having the general formula (3): synthesis, intermediates and uses thereof.
    Type: Application
    Filed: September 25, 2008
    Publication date: August 5, 2010
    Applicants: UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA", UNIVERSITA DEGLI STUDI DI SIENA
    Inventors: Mariangela Biava, Giulio Cesare Porretta, Raffaello Pompei, Maurizio Botta, Fabrizio Manetti, Alessandro De Logu
  • Derivatives of 1--4-methylpiperazine, synthesis process and uses thereof
    Publication number: 20090281094
    Abstract: The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine (BM212). The invention concerns the use of the described compounds as antitubercular agents having high activity and low toxicity and process to obtain intermediates and final compounds.
    Type: Application
    Filed: March 3, 2006
    Publication date: November 12, 2009
    Inventors: Mariangela Biava, Fabrizio Manetti, Delia Deidda, Raffaello Pompei, Maurizio Botta, Giulio Cesare Porretta
  • Substituted pyrazolo[3,4-D]pyrimidines as anti-tumor agents
    Patent number: 7589086
    Abstract: The present invention provides a compound of pyrazolo[3,4-d]pyrimidine having the formula wherein: X=N; R=H, alkylthio, or aminoalkylthio; R1=NHcyclopropyl, NHC3H7, NHC4H9, N(CH2CH3)2, NHCH2CH2OC2H5, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, NHcyclohexyl, 1-hexahydroazepinyl, NHCH2C6H5, or NHCH2CH2C6H5; wherein R3=H, halogen, or alkyl and R5=Cl, Br or OH.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: September 15, 2009
    Assignee: Universita degli Studi di Siena
    Inventors: Francesco Bondavalli, Maurizio Botta, Olga Bruno, Fabrizio Manetti, Silvia Schenone, Fabio Carraro
  • Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity
    Patent number: 7368605
    Abstract: Formula (I) compounds are described where the groups are as identified in the text, and their use as medicines, particularly as anti-diabetes, serum glucose-lowering and anti-obesity agents. They are useful for the prophylaxis and treatment of diabetes, particularly type 2 diabetes, and its complications, syndrome X, the various forms of insulin resistance, and hyperlipidaemias, as well as for the treatment of obesity.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: May 6, 2008
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Emanuela Tassoni, Maria Ornella Tinti, Pompeo Pessotto, Maurizio Botta, Pederico Corelli
  • 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof
    Publication number: 20070010510
    Abstract: 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. Compounds are active as antitumoural agents.
    Type: Application
    Filed: May 26, 2004
    Publication date: January 11, 2007
    Inventors: Francesco Bondavalli, Maurizio Botta, Olga Bruno, Fabrizio Manetti, Silvia Schenone, Fabio Carraro
  • Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity
    Publication number: 20060069100
    Abstract: Formula (I) compounds are described where the groups are as identified in the text, and their use as medicines, particularly as anti-diabetes, serum glucose-lowering and anti-obesity agents. Said medicines are useful for the prophylaxis and treatment of diabetes, particularly type 2 diabetes, and its complications, syndrome X, the various forms of insulin resistance, and hyperlipidaemias, as well as for the treatment of obesity.
    Type: Application
    Filed: December 1, 2003
    Publication date: March 30, 2006
    Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Emanuela Tassoni, Maria Tinti, Pompeo Pessotto, Maurizio Botta, Pederico Corelli