Patents by Inventor Mauro Ferrari

Mauro Ferrari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190111000
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 18, 2019
    Applicants: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Patent number: 10253424
    Abstract: Provided is a particle that includes a first porous region and a second porous region that differs from the first porous region. Also provided is a particle that has a wet etched porous region and that does have a nucleation layer associated with wet etching. Methods of making porous particles are also provided.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: April 9, 2019
    Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Mauro Ferrari, Xuewu Liu, Ming-Cheng Cheng
  • Publication number: 20190001025
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Application
    Filed: August 27, 2018
    Publication date: January 3, 2019
    Applicant: Board of Regents of the University of Texas System
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Publication number: 20180361030
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 20, 2018
    Applicant: Board of Regents of the University of Texas System
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Patent number: 10143658
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: December 4, 2018
    Assignees: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Patent number: 10087442
    Abstract: Disclosed are methods and compositions containing functionalized nanoporous silicon particles, useful in a variety of diagnostic and/or therapeutic regimens for delivery of genetic constructs to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing into selected host cells one or more selected nucleic acid molecules. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual one or more of the compositions and formulations thereof as described herein.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: October 2, 2018
    Assignee: The Methodist Hospital
    Inventors: Haifa Shen, Mauro Ferrari, Jianliang Shen, Mingzhen Zhang
  • Patent number: 10058633
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: August 28, 2018
    Assignee: Board of Regents of the University of Texas System
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Publication number: 20180117176
    Abstract: Porous silicon (pSi) microparticles (PSM) are disclosed, which provide an important advance in the area of cancer immunotherapeutics and molecular nanomedicine. In particular, potent PSM-based adjuvants are disclosed for dendritic cell-based vaccines compositions, and methods for their use in a variety of cancer immunotherapies. The PSM of the present invention are also useful in developing other types of vaccines, including those not necessarily related to the treatment of cancers, such as vaccines for the treatment of acne, Alzheimer's disease, asthma, atherosclerosis, autoimmune disorders, autoinflammatory disease, celiac disease, colitis, Crohn's disease, diabetes, glomerulonephritis, infectious diseases, inflammatory bowel disease, irritable bowel syndrome, ischemia, Lupus, pelvic inflammatory disease, reperfusion injury, rheumatoid arthritis, sarcoidosis, transplant rejection, West Nile virus, and related illnesses.
    Type: Application
    Filed: December 6, 2017
    Publication date: May 3, 2018
    Inventors: Haifa SHEN, Xiaojun XIA, Mauro FERRARI
  • Publication number: 20170172450
    Abstract: Disclosed are method of detecting or characterizing a tumor by quantitatively measuring and comparing changes in mass transfer into the tumor and normal tissue over time using computed tomography or magnetic resonance imaging. The methods can be used to predict therapeutic response to treatment and to develop treatment plans.
    Type: Application
    Filed: March 6, 2015
    Publication date: June 22, 2017
    Inventors: Eugene KOAY, Vittorio CRISTINI, Jason FLEMING, Priya BHOSALE, Christopher CRANE, Haifa SHEN, Mauro FERRARI
  • Publication number: 20170136154
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Application
    Filed: September 20, 2016
    Publication date: May 18, 2017
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Publication number: 20170056327
    Abstract: Disclosed are micro/nano composite drug delivery compositions for use in diagnosis, prophylaxis, treatment and/or amelioration of one or more symptoms of a mammalian disease, disorder, dysfunction, or abnormal condition. In illustrative embodiments, pharmaceutical formulations comprising these composites are provided that are useful in methods for targeting selected mammalian cells and tissues, particularly human lung tissue, and delivering one or more therapeutic agents, particularly in the treatment of human lung cancers, such as melanoma lung metastases.
    Type: Application
    Filed: August 25, 2016
    Publication date: March 2, 2017
    Inventors: Yu MI, Mauro FERRARI
  • Patent number: 9526824
    Abstract: A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: December 27, 2016
    Assignees: The Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Xuewu Liu, Alessandro Grattoni, Daniel Fine, Randy Goodall, Sharath Hosali, Ryan Medema, Lee Hudson
  • Publication number: 20160369269
    Abstract: Disclosed are methods and compositions containing functionalized nanoporous silicon particles, useful in a variety of diagnostic and/or therapeutic regimens for delivery of genetic constructs to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing into selected host cells one or more selected nucleic acid molecules. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual one or more of the compositions and formulations thereof as described herein.
    Type: Application
    Filed: December 11, 2015
    Publication date: December 22, 2016
    Inventors: Haifa Shen, Mauro Ferrari, Jian Shen, Mingzhen Zhang
  • Publication number: 20160051481
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Application
    Filed: May 29, 2015
    Publication date: February 25, 2016
    Applicants: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Publication number: 20160032480
    Abstract: Provided is a particle that includes a first porous region and a second porous region that differs from the first porous region. Also provided is a particle that has a wet etched porous region and that does have a nucleation layer associated with wet etching. Methods of making porous particles are also provided.
    Type: Application
    Filed: November 11, 2014
    Publication date: February 4, 2016
    Applicants: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Xuewu Liu, Ming-Cheng Cheng
  • Patent number: 9196465
    Abstract: A method for detecting hepcidin. Having a sample liquid in contact with a nanochip having a specific surface coating structure of silicon oxide, so that hepcidin is enriched with specificity; eluting the nanochip with an eluent; by performing mass spectrometric detection on the elution product, determining the hepcidin content in the elution product. The enrichment method substantially enhances the sensitivity and accuracy of mass spectrometric detection. A kit for detecting hepcidin comprising a sample diluent and a nanochip, the sample diluent comprising water, trifluoroacetic acid, and acetonitrile.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: November 24, 2015
    Assignee: National Center for Nanoscience and Technology
    Inventors: Guangjun Nie, Tony Hu, Jia Fan, Yuliang Zhao, Mauro Ferrari
  • Publication number: 20150246174
    Abstract: A capsule configured for in vivo refilling of a therapeutic agent. In certain embodiments, the capsule may contain methotrexate.
    Type: Application
    Filed: March 16, 2015
    Publication date: September 3, 2015
    Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Mauro Ferrari, Xuewu Liu, Alessandro Grattoni, Randy Goodall, Lee Hudson
  • Publication number: 20150158195
    Abstract: An apparatus for slicing food products includes a container for the food product and a movable carriage carrying the container and product towards a cutting plane defined by a rotating blade. After slicing, the container can be removed from the carriage and then vacuum sealed for preserving the remaining unsliced product.
    Type: Application
    Filed: April 10, 2013
    Publication date: June 11, 2015
    Applicant: Idea S.r.I.
    Inventors: Mauro Ferrari, Dario Gualini, Pietro Tomasoni
  • Patent number: 9005185
    Abstract: A capsule configured for in vivo refilling of a therapeutic agent. In certain embodiments, the capsule may contain methotrexate.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: April 14, 2015
    Assignees: The Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Xuewu Liu, Alessandro Grattoni, Randy Goodall, Lee Hudson
  • Publication number: 20150088102
    Abstract: A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, electrodes and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
    Type: Application
    Filed: August 1, 2014
    Publication date: March 26, 2015
    Inventors: Daniel FINE, Alessandro GRATTONI, Mauro FERRARI, Xuewu LIU, Randal GOODALL, Sharath HOSALI