Patents by Inventor Mauro Ferrari

Mauro Ferrari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210338593
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Application
    Filed: July 6, 2021
    Publication date: November 4, 2021
    Applicants: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Patent number: 10987500
    Abstract: A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, electrodes and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: April 27, 2021
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Daniel Fine, Alessandro Grattoni, Mauro Ferrari, Xuewu Liu, Randal Goodall, Sharath Hosali
  • Publication number: 20210059942
    Abstract: The present disclosure is directed to a composition for the sustained-release delivery of an active agent to a target cell of an individual. The compositions disclosed herein comprise of at least one porous particle; at least one polymer; and at least one active agent. In an embodiment, the porous particle comprises a plurality of microscale reservoirs. In an exemplary embodiment, the at least one active agent is covalently linked to the at least one polymer to form a polymer-active agent conjugate, and the polymer-active agent conjugate is contained in the plurality of microscale reservoirs of the porous particle. In some embodiments, the active agent is released with zero-order or near zero-order kinetics following administration of the composition. The present disclosure is also directed to a method of treating a tumor by administering to an individual the composition described supra.
    Type: Application
    Filed: November 12, 2020
    Publication date: March 4, 2021
    Applicant: The Methodist Hospital Research Institute
    Inventors: Haifa Shen, Mauro Ferrari, Xiaoyong Deng, Guodong Zhang
  • Patent number: 10842749
    Abstract: The present disclosure is directed to a composition for the sustained-release delivery of an active agent to a target cell of an individual. The compositions disclosed herein comprise of at least one porous particle; at least one polymer; and at least one active agent. In an embodiment, the porous particle comprises a plurality of microscale reservoirs. In an exemplary embodiment, the at least one active agent is covalently linked to the at least one polymer to form a polymer-active agent conjugate, and the polymer-active agent conjugate is contained in the plurality of microscale reservoirs of the porous particle. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual the composition described supra. Additionally, disclosed herein is a method of eliminating tumor stem cells. Furthermore, there is provided a method of circumventing multi-drug resistance in a tumor cell.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: November 24, 2020
    Assignee: The Methodist Hospital Research Institute
    Inventors: Haifa Shen, Mauro Ferrari, Xiaoyong Deng, Guodong Zhang
  • Patent number: 10773846
    Abstract: An anvil for transversally sealing a tube having a longitudinal seam portion can include a first elongate contact surface and a second elongate contact surface. In some embodiments, the first elongate contact surface includes a first groove and the second elongate contact surface includes a second groove, each one of the first groove and the second groove being adapted to receive, in use, a respective section of the longitudinal seam portion of the tube. The first elongate contact surface can include a first seam interaction portion positioned within the first groove and having a first surface profile. The second elongate contact surface can include a second seam interaction portion positioned within the second groove and having a second surface profile. In some embodiments, the first surface profile differs from the second surface profile.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 15, 2020
    Assignee: Tetra Laval Holdings & Finance S.A.
    Inventors: Luca Gentili, Mauro Ferrari, Fabrizio Fenu
  • Publication number: 20200172278
    Abstract: An anvil for transversally sealing a tube having a longitudinal seam portion can include a first elongate contact surface and a second elongate contact surface. In some embodiments, the first elongate contact surface includes a first groove and the second elongate contact surface includes a second groove, each one of the first groove and the second groove being adapted to receive, in use, a respective section of the longitudinal seam portion of the tube. The first elongate contact surface can include a first seam interaction portion positioned within the first groove and having a first surface profile. The second elongate contact surface can include a second seam interaction portion positioned within the second groove and having a second surface profile. In some embodiments, the first surface profile differs from the second surface profile.
    Type: Application
    Filed: July 30, 2018
    Publication date: June 4, 2020
    Inventors: Luca Gentili, Mauro Ferrari, Fabrizio Fenu
  • Publication number: 20190211328
    Abstract: Disclosed are methods and compositions containing functionalized nanoporous silicon particles, useful in a variety of diagnostic and/or therapeutic regimens for delivery of genetic constructs to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing into selected host cells one or more selected nucleic acid molecules. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual one or more of the compositions and formulations thereof as described herein.
    Type: Application
    Filed: October 2, 2018
    Publication date: July 11, 2019
    Inventors: Haifa Shen, Mauro Ferrari, Jianliang Shen, Mingzhen Zhang
  • Publication number: 20190111000
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 18, 2019
    Applicants: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Patent number: 10253424
    Abstract: Provided is a particle that includes a first porous region and a second porous region that differs from the first porous region. Also provided is a particle that has a wet etched porous region and that does have a nucleation layer associated with wet etching. Methods of making porous particles are also provided.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: April 9, 2019
    Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Mauro Ferrari, Xuewu Liu, Ming-Cheng Cheng
  • Publication number: 20190001025
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Application
    Filed: August 27, 2018
    Publication date: January 3, 2019
    Applicant: Board of Regents of the University of Texas System
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Publication number: 20180361030
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 20, 2018
    Applicant: Board of Regents of the University of Texas System
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Patent number: 10143658
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: December 4, 2018
    Assignees: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Patent number: 10087442
    Abstract: Disclosed are methods and compositions containing functionalized nanoporous silicon particles, useful in a variety of diagnostic and/or therapeutic regimens for delivery of genetic constructs to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing into selected host cells one or more selected nucleic acid molecules. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual one or more of the compositions and formulations thereof as described herein.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: October 2, 2018
    Assignee: The Methodist Hospital
    Inventors: Haifa Shen, Mauro Ferrari, Jianliang Shen, Mingzhen Zhang
  • Patent number: 10058633
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: August 28, 2018
    Assignee: Board of Regents of the University of Texas System
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Publication number: 20180117176
    Abstract: Porous silicon (pSi) microparticles (PSM) are disclosed, which provide an important advance in the area of cancer immunotherapeutics and molecular nanomedicine. In particular, potent PSM-based adjuvants are disclosed for dendritic cell-based vaccines compositions, and methods for their use in a variety of cancer immunotherapies. The PSM of the present invention are also useful in developing other types of vaccines, including those not necessarily related to the treatment of cancers, such as vaccines for the treatment of acne, Alzheimer's disease, asthma, atherosclerosis, autoimmune disorders, autoinflammatory disease, celiac disease, colitis, Crohn's disease, diabetes, glomerulonephritis, infectious diseases, inflammatory bowel disease, irritable bowel syndrome, ischemia, Lupus, pelvic inflammatory disease, reperfusion injury, rheumatoid arthritis, sarcoidosis, transplant rejection, West Nile virus, and related illnesses.
    Type: Application
    Filed: December 6, 2017
    Publication date: May 3, 2018
    Inventors: Haifa SHEN, Xiaojun XIA, Mauro FERRARI
  • Publication number: 20170172450
    Abstract: Disclosed are method of detecting or characterizing a tumor by quantitatively measuring and comparing changes in mass transfer into the tumor and normal tissue over time using computed tomography or magnetic resonance imaging. The methods can be used to predict therapeutic response to treatment and to develop treatment plans.
    Type: Application
    Filed: March 6, 2015
    Publication date: June 22, 2017
    Inventors: Eugene KOAY, Vittorio CRISTINI, Jason FLEMING, Priya BHOSALE, Christopher CRANE, Haifa SHEN, Mauro FERRARI
  • Publication number: 20170136154
    Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.
    Type: Application
    Filed: September 20, 2016
    Publication date: May 18, 2017
    Inventors: Mauro Ferrari, Rachel Buchanan, Christine Smid, Ennio Tasciotti
  • Publication number: 20170056327
    Abstract: Disclosed are micro/nano composite drug delivery compositions for use in diagnosis, prophylaxis, treatment and/or amelioration of one or more symptoms of a mammalian disease, disorder, dysfunction, or abnormal condition. In illustrative embodiments, pharmaceutical formulations comprising these composites are provided that are useful in methods for targeting selected mammalian cells and tissues, particularly human lung tissue, and delivering one or more therapeutic agents, particularly in the treatment of human lung cancers, such as melanoma lung metastases.
    Type: Application
    Filed: August 25, 2016
    Publication date: March 2, 2017
    Inventors: Yu MI, Mauro FERRARI
  • Patent number: 9526824
    Abstract: A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: December 27, 2016
    Assignees: The Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Xuewu Liu, Alessandro Grattoni, Daniel Fine, Randy Goodall, Sharath Hosali, Ryan Medema, Lee Hudson
  • Publication number: 20160369269
    Abstract: Disclosed are methods and compositions containing functionalized nanoporous silicon particles, useful in a variety of diagnostic and/or therapeutic regimens for delivery of genetic constructs to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing into selected host cells one or more selected nucleic acid molecules. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual one or more of the compositions and formulations thereof as described herein.
    Type: Application
    Filed: December 11, 2015
    Publication date: December 22, 2016
    Inventors: Haifa Shen, Mauro Ferrari, Jian Shen, Mingzhen Zhang