Patents by Inventor Mauro Ferrari

Mauro Ferrari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080102030
    Abstract: Provided is a composition that includes oblate spheroidal particles comprising an active agent, such as a therapeutic or imaging agent, and a method for treating or monitoring a physiological condition, such as a disease, by administering the composition to a subject in need thereof. Also provided are methods for making particles that have a volume that can enhance the particles' adhesion to a target site in a subject's body for a pre-selected shape of the particles and methods for making particles that have a shape that can enhance particles' adhesion to a target site in a subject's body for a pre-selected volume of the particles.
    Type: Application
    Filed: October 10, 2007
    Publication date: May 1, 2008
    Inventors: Paolo DECUZZI, Mauro FERRARI
  • Publication number: 20080033397
    Abstract: A method for releasing an aortic prosthesis includes positioning an introducer in femoral arteries of a patient. Guiding balloon catheters are positioned through the introducers to locate balloons thereof in terminal parts of common iliac arteries. The proximal aorta is clamped, balloons of the guiding catheters are inflated, and the aorta is opened for outside access. Distal ends of releasing balloon catheters are threaded through the guiding catheters and are recovered outside the patient through the introducers. Distal ends of the releasing catheters are connected to distal portions of the prosthesis, which is moved by the catheters until distal portions thereof contact the guiding catheters. The proximal part of the prosthesis is sutured to the aorta. The balloons of the releasing catheters are inflated to fix the distal portions of the prosthesis. Balloons are deflated, catheters are removed, the aorta is sutured, and the introducers are removed.
    Type: Application
    Filed: May 7, 2007
    Publication date: February 7, 2008
    Inventors: Francesco Serino, Mauro Ferrari
  • Publication number: 20070299340
    Abstract: A system and method for screening tissue is provided. The system provides a computer-based system for distinguishing between normal and potentially abnormal tissue. The system includes computer components for generating and receiving ultrasonic waves, for storing a tissue model, and for analyzing received ultrasonic waves in the context of the tissue model.
    Type: Application
    Filed: May 17, 2007
    Publication date: December 27, 2007
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Jun Liu, Mauro Ferrari, Stanislav Rokhlin, Daniel Sedmak
  • Patent number: 7235094
    Abstract: A bifurcated vascular prosthesis implanted using a combined laparoscopic/open and endovascular technique for curing aneurysms of the abdominal aorta includes two stents on distal arms of the prosthesis. A delivery system and surgical kit for the release of the vascular prosthesis includes a pair of balloon release catheters, to be inserted within each corresponding stent and to remain adhering thereto throughout the time prior to release until reinflated with an inflating syringe, and a pair of balloon guide catheters, each including a dilator and a sheath. A method for implanting the prosthesis is also provided.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: June 26, 2007
    Assignee: Bolton Medical, Inc.
    Inventors: Francesco Serino, Mauro Ferrari
  • Publication number: 20070066138
    Abstract: The invention generally relates to diffusion delivery systems and more particularly to high precision nanoengineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems.
    Type: Application
    Filed: April 5, 2006
    Publication date: March 22, 2007
    Applicant: The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Xuewu Liu, Piyush Sinha, Bryan Smith, Sadhana Sharma
  • Publication number: 20060271103
    Abstract: A clip for closing blood vessels which branch off from a main blood vessel during an intervention of the main blood vessel has a base body via which the clip can be placed on an inside face of the opened main blood vessel. At least three limbs protrude from the base body and are able to be bent in the direction towards the base body in order to clamp tissue in the area of the branch between the base body and the bent-back limbs thereby closing said branch.
    Type: Application
    Filed: December 1, 2005
    Publication date: November 30, 2006
    Inventors: Mauro Ferrari, Cesare Stefanini
  • Publication number: 20040111145
    Abstract: A bifurcated vascular prosthesis implanted using a combined laparoscopic/open and endovascular technique for curing aneurysms of the abdominal aorta includes two stents on distal arms of the prosthesis. A delivery system and surgical kit for the release of the vascular prosthesis includes a pair of balloon release catheters, to be inserted within each corresponding stent and to remain adhering thereto throughout the time prior to release until reinflated with an inflating syringe, and a pair of balloon guide catheters, each including a dilator and a sheath. A method for implanting the prosthesis is also provided.
    Type: Application
    Filed: November 20, 2003
    Publication date: June 10, 2004
    Inventors: Francesco Serino, Mauro Ferrari
  • Publication number: 20040064050
    Abstract: A system and method for screening tissue is provided. The system provides a computer-based system for distinguishing between normal and potentially abnormal tissue. The system includes computer components for generating and receiving ultrasonic waves, for storing a tissue model, and for analyzing received ultrasonic waves in the context of the tissue model.
    Type: Application
    Filed: September 20, 2002
    Publication date: April 1, 2004
    Inventors: Jun Liu, Mauro Ferrari, Stanislav I. Rokhlin, Daniel D. Sedmak
  • Publication number: 20030205552
    Abstract: A method of forming a membrane having nanometer scale pores includes forming an etch stop layer on a substrate and forming a base layer on the etch stop layer. Advantageously, a silicon nitride etch stop layer is formed on a silicon substrate and the base layer is a thermally grown oxide layer. Micron scale holes are etched through the base layer and, advantageously, partially through the underlying etch stop layer. A sacrificial base layer of controlled thickness is formed on the base layer and lining the holes. A thermally grown oxide is advantageously used as the sacrificial base layer. A plug layer is then formed on the base layer, on the sacrificial base layer and filling the holes. Polysilicon is advantageously used as the plug layer. The plug layer is planarized followed by the creation of an aperture in the backside of the wafer.
    Type: Application
    Filed: May 16, 2003
    Publication date: November 6, 2003
    Applicant: The Regents of the University of California
    Inventors: Derek J. Hansford, Mauro Ferrari
  • Publication number: 20030114366
    Abstract: Microfabricated, asymmetrical, reservoir-containing particles for use in the intravenous delivery of cytotoxic agents such as melittin to tumors is disclosed. The particles have a selected shape and uniform dimensions preferably in the 1 &mgr;m to 10 &mgr;m range. The reservoirs open to the face of the particle and are filled with a solution or suspension of the therapeutic agent and selected excipients. The drug/excipient solution may be dried by standard techniques. The excipients are selected to delay the dissolution/release of the agent from the particle reservoirs for 1-48 hours after the particle suspension is rehydrated and injected. Alternatively, the pore is plugged with an erodable material or covered with a semipermeable membrane. The face of the particle is grafted with a layer of specific ligands designed to quickly bind the particle to the surface of either tumor cells or the vascular endothelial cells, which form tumor capillaries.
    Type: Application
    Filed: January 6, 2000
    Publication date: June 19, 2003
    Inventors: FRANCIS J. MARTIN, MAURO FERRARI
  • Patent number: 6405066
    Abstract: An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon and has a glucose diffusion test result of at least 1 mg/dl in 330 min., and an albumin diffusion test result of at most 0.1 g/dl in 420 min.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: June 11, 2002
    Assignees: The Regents of the University of California, Roche Diagnostics Corporation
    Inventors: Matthias Essenpreis, Tejal A. Desai, Mauro Ferrari, Derek J. Hansford
  • Patent number: 6355270
    Abstract: Microfabricated, asymmetrical, reservoir-containing particles for use in the oral delivery of biopolymer therapeutic agents such as peptides, proteins and oligonucleotides are disclosed. The particles are encapsulated in enteric-coated capsules or tablets to provide passage through the stomach and release of a suspension of the particles in the intestinal lumen. The particles have a selected shape, and uniform dimensions preferably in the 100 &mgr;m to 1 mm range. The reservoirs open to the face of the particle and are filled with a therapeutic agent and selected excipients. The excipients are selected to delay the dissolution/release of the agent from the particle reservoirs for 5-60 minutes after the particle is released in the intestinal lumen. Alternatively, the pore is plugged with an erodable material.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: March 12, 2002
    Assignee: The Regents of the University of California
    Inventors: Mauro Ferrari, Peter J. Dehlinger, Francis J. Martin, Carl F. Grove, David R. Friend
  • Patent number: 6107102
    Abstract: A suspension of microfabricated microdevices for use in therapeutic applications is disclosed. The microdevices have a selected shape, and uniform dimensions preferably in the 100 nm to 10 Am range. Also disclosed are microfabrication methods for making such microdevices.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: August 22, 2000
    Assignee: Regents of the University of California
    Inventor: Mauro Ferrari
  • Patent number: 6044981
    Abstract: Microfabricated filters utilizing a bulk substrate structure and a thin film structure and a method for constructing such filters. The pores of the filters are defined by spaces between the bulk substrate structure and the thin film structure and are of substantially uniform width, length and distribution. The width of the pores is defined by the thickness of a sacrificial layer and therefore may be smaller than the limit of resolution obtainable with photolithography. The filters provide enhanced mechanical strength, chemical inertness, biological compatibility, and throughput. The filters are constructed using relatively simple fabrication techniques. Also, microfabricated containment wells and capsules constructed with such filters for the immunological isolation of cell transplants and a method for constructing such containment wells and capsules.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: April 4, 2000
    Assignee: The Regents of the University of California
    Inventors: Wen-Hwa Chu, Mauro Ferrari
  • Patent number: 6015599
    Abstract: This invention relates to the area of microelectromechanical systems in which electronic circuits and mechanical devices are integrated on the same silicon chip. The method taught herein allows the fabrication of thin film structures in excess of 150 microns in height using thin film deposition processes. Wafers may be employed as reusable molds for efficient production of such structures.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 18, 2000
    Assignee: Regents of the University of California
    Inventors: Christopher G. Keller, Mauro Ferrari
  • Patent number: 5985328
    Abstract: A microfabricated containment capsule has a bulk substrate delimiting a cavity with a boundary, a first portion of which constitutes an inner wall of a solid portion of the bulk substrate. The bulk substrate also provides at a second portion of the boundary a membrane joined to one side of the bulk substrate, the membrane having at least one porous area with controlled pores.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: November 16, 1999
    Assignee: Regents of the University of California
    Inventors: Wen-Hua Chu, Mauro Ferrari
  • Patent number: 5985164
    Abstract: Surface micromachining and bulk micromachining are employed for realizing a porous membrane with bulk support for a microparticle filter. The filter is manufactured by a process employing a thin film etch-stop, in which the bulk substrate is etched using a first etching process followed by etching of the etch stop and of material within pores of a filter layer using a second etching process. The filter is sufficiently sturdy to allow for easy handling. It may be used as a diffusion barrier and under high pressures. The disclosed fabrication method is simple, reliable, and integrated-circuit compatible, and thus amenable to mass production. Electronic circuitry may be integrated on the filter surface, as may be desired for several purposes, such as fluid characterization, filter self-cleaning, or charging of the filter surfaces. Methods are shown for the realization of biological containment capsules based on this microfilter.
    Type: Grant
    Filed: October 15, 1997
    Date of Patent: November 16, 1999
    Assignee: Regents of the University of California
    Inventors: Wen-Hua Chu, Mauro Ferrari
  • Patent number: 5948255
    Abstract: A thin film filter fabricated using surface micromachining. The width of the filter pores is determined by the thickness of a sacrificial thin-film layer. This dimension can be precisely controlled, and may be as small as about 50 angstroms. The pore length may also be determined by the thickness of thin film layers and can therefore be smaller than the limit of resolution obtainable with photolithography. The filters are suitable for use at high temperatures and with many harsh solvents.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: September 7, 1999
    Assignee: The Regents of the University of California
    Inventors: Christopher G. Keller, Mauro Ferrari
  • Patent number: 5938923
    Abstract: A microfabricated filter made up of two bonded substrate structures, each consisting of single crystalline silicon can optionally be formed into a capsule. The pores of the filter consist of one or more channels disposed between the two substrate structures. The width of the channels are defined by a thickness of a sacrificial layer formed on one of the substrate structures. The filter includes pores having a precisely controlled pore width which may be as small as 5 nanometers. The filter provides a relatively high mechanical strength relative to filters having polycrystalline silicon structures and also has a high throughput and can be modified to have high resistance to adsorption of particles.
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: August 17, 1999
    Assignee: The Regents of the University of California
    Inventors: Jay Kuang-Jieh Tu, Mauro Ferrari
  • Patent number: 5893974
    Abstract: The present invention provides a capsule made of a biologically compatible material with sufficient mechanical strength to form a very thin membrane shell having at least a region with approximately uniformly sized and spaced holes or pores that are large enough to let a desired biologically active molecular product through, while blocking the passage of all larger immunological molecules. The present invention thus provides an immunological isolation of cell transplants contained therein. The present invention also provides a free standing thin film structure that may be used as a component of such a capsule and method for the fabrication of such component and capsules.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: April 13, 1999
    Assignee: Regents of University of California
    Inventors: Christopher G. Keller, Mauro Ferrari