Abstract: The invention describes catheter systems and methods for accessing the brain during endovascular/neurointervention procedures in the treatment of ischemic stroke. More specifically, a multi-axial catheter system and kit is described that improves the process of accessing a carotid artery particularly in patients having a tortuous aortic arch and thereafter improves the process of gaining access to the brain to enable the insertion of aspiration and/or the deployment clot retrieval devices. In addition, methods of utilizing these systems are described.

Abstract: An automated system and method for assisting in decision making for the treatment of stroke patients is provided, and specifically for assisting a physician whether the patient should be administered a drug or transferred to another hospital to undergo an endovascular thrombectomy procedure. A variety of factors are input into the system with limited human intervention and a tool automatically determines the probability of whether the patient will have a better outcome if transferred or not. The factors include clinical factors, imaging factors and time to transfer factors. The tool includes processes for automatically determining several imaging factors, including the determination of clot length, collateral blood flow, the presence of forward blood flow within and around the clot, and the clot permeability. The tool has capability to continuously update the treatment protocol and other output results using current clinical, health system or other relevant information or feedback.

Abstract: An obstruction removal device is described, having one or more engaging members which can engage portions of the clot. The one or more engaging members have a collapsed, delivery state, and an expanded, deployed state which in some embodiments can be locked to maintain its fixed configuration.

Abstract: The invention relates to systems and methods for intracranial vessel access. In particular, a system including a co-axial combination of a steerable variable thickness microwire operatively supporting a tapered larger bore support and larger bore distal access catheter is described. Methods of advancing the intracranial access system through the vasculature are also described.

Abstract: The invention describes catheter systems and methods for accessing the brain during endovascular/neurointervention procedures in the treatment of ischemic stroke. More specifically, a multi-axial catheter system and kit is described that improves the process of accessing a carotid artery particularly in patients having a tortuous aortic arch and thereafter improves the process of gaining access to the brain to enable the insertion of aspiration and/or the deployment clot retrieval devices. In addition, methods of utilizing these systems are described.

Abstract: The invention relates to systems and methods for intracranial vessel access. In particular, a system including a co-axial combination of a steerable variable thickness microwire operatively supporting a tapered larger bore support and larger bore distal access catheter is described. Methods of advancing the intracranial access system through the vasculature are also described.

Abstract: The invention relates to systems and methods for predicting ischemic brain tissue fate from multi-phase CT-angiography. More specifically, systems and methods are provided that enable meaningful prediction of core, penumbra and perfusion from mCTA images using software that has been trained via machine learning to interpret mCTA images.

Abstract: Systems and methods to enhance the efficiency of initiating, conducting and funding research projects are described. The system includes a plurality of attributes relevant to users of the system including donors, potential donors, researchers and research projects. The system utilizes matching strategies to present research projects to donors that may best align with the donor's interests as defined by their attributes. The system includes negative and serendipitous strategies to also present research projects to donors that are not necessarily aligned with the donor's interests as defined by their attributes.

Abstract: The invention relates to systems and methods for predicting ischemic brain tissue fate from multi-phase CT-angiography. More specifically, systems and methods are provided that enable meaningful prediction of core, penumbra and perfusion from mCTA images using software that has been trained via machine learning to interpret mCTA images.

Abstract: The invention relates generally to increasing the efficiency of knowledge sharing promoting research and innovation, and more specifically to increasing the efficiency of knowledge sharing and collaboration between participants/experts in particular fields. In particular, a system is described that supports each of a discussion group, working group and research group, wherein modules supporting each group has particular functionality to enable people discuss and define new problems, begin working together to advance collaboration to solve a problem and to assist in establishing a real-world research project.

Abstract: Systems and methods for accessing small arteries for conveying catheters to target vessels such as brain vessels are described. In particular, the invention describes systems enabling a catheter to be introduced directly through a vessel opening without an external sheath wherein a distal tip of the catheter is protected by a protective cover. Methods of introducing catheters into vessels and kits are also described.

Abstract: An obstruction removal device is described, having one or more engaging members which can engage portions of the clot. The one or more engaging members have a collapsed, delivery state, and an expanded, deployed state which in some embodiments can be locked to maintain its fixed configuration.

Abstract: The invention relates to systems and methods to assist physicians in decision making for stroke patients. In particular the systems and methods can be used to assist physicians to decide on whether a patient with an acute ischemic stroke has a large vessel occlusion (LVO) and should be transferred from a community hospital to a larger hospital to undergo an endovascular thrombectomy procedure.

Abstract: The invention relates to systems and methods for assisting a physician in making treatment decisions and to assist in the planning of endovascular surgical procedures. In particular, the invention relates to systems and methods for helping a physician decide if access to the cervical and cerebral arteries is best achieved via a radial artery or femoral artery access route (or other) based on objective assessment of the likelihood of success by a specific access point and having consideration to the available endovascular equipment and a particular patient's anatomy.

Abstract: Systems and methods enabling a personalized solution for allowing more efficient access to the carotid artery (or vertebral arteries) m patients needing endovascular/neurointervention procedures using catheter systems.

Abstract: The invention describes catheter systems and methods for accessing the brain during endovascular/neurointervention procedures in the treatment of ischemic stroke. More specifically, a catheter system having a deployable redirection device (RD) is described that improves the process of accessing a clot in a patient with acute ischemic stroke due to large vessel occlusion.

Abstract: A distal entry point (DEP) to brain aspiration (D2BA) catheter for use in an endovascular procedure for gaining access to cervical and cerebral arteries in a brain of a patient and aspirating one or more intracranial clots from the cerebral arteries, comprising a soft distal tip region having a distal length sufficient to extend from a level 1 or level 2 arterial segment of a cerebral artery or equivalent to an upper neck arterial vessel, a stiffness enabling movement through the level 1 or level 2 arterial segment of the cerebral artery, and an outside diameter (OD) of 6F-10F, a proximal region having a stiffness greater than the stiffness of the soft distal tip region, the proximal region having a length sufficient to extend to outside the patient through the DEP.

Abstract: An obstruction removal device is described, having one or more engaging members which can engage portions of the clot. The one or more engaging members have a collapsed, delivery state, and an expanded, deployed state which in some embodiments can be locked to maintain its fixed configuration.

Abstract: A client device is tracked over a period of time using “refresh tokens” that are exchanged in conjunction with routine client-server communications. Each communication cycle between client and server includes a refresh token that is recorded at the server. The recorded refresh tokens are mapped to both server- and client-generated device identifiers. As communications between client and server occur, a chain of tokens, one for each communication cycle, is progressively recorded at the server. If the server receives a token that is outdated with respect to that which is otherwise expected based on the progression of the recorded chain, this suggests that the received communication was transmitted from a device that is a clone of another client device. A more robust device identification framework is therefore achieved by using a combination of device identifiers and tokens exchanged between client and server.

Abstract: The invention relates to systems and methods to assist physicians in decision making for stroke patients. In particular the systems and methods can be used to assist physicians to decide on whether a patient with an acute ischemic stroke has a large vessel occlusion (LVO) and should be transferred from a community hospital to a larger hospital to undergo an endovascular thrombectomy procedure.