Abstract: The invention relates to systems and methods for intracranial vessel access. In particular, the systems include a system including a co-axial combination of a steerable variable thickness microwire operatively supporting a tapered larger bore support and a larger bore distal access catheter. The methods for intracranial vessel access include methods of advancing the system through vasculature.

Abstract: The invention relates to systems and methods for predicting ischemic brain tissue fate from multi-phase CT-angiography. More specifically, systems and methods are provided that enable meaningful prediction of core, penumbra and perfusion from mCTA images using software that has been trained via machine learning to interpret mCTA images.

Abstract: The invention describes catheter systems and methods for accessing the brain during endovascular/neurointervention procedures in the treatment of ischemic stroke. More specifically, a multi-axial catheter system and kit is described that improves the process of accessing a carotid artery particularly in patients having a tortuous aortic arch and thereafter improves the process of gaining access to the brain to enable the insertion of aspiration and/or the deployment clot retrieval devices. In addition, methods of utilizing these systems are described.

Abstract: Rapid diagnosis of acute ischemic stroke (AIS), and endovascular treatment—that is mechanical removal of the clot with endovascular devices—together leads to better outcomes. Systems and methods for decreasing the time to diagnosis are described that include imaging techniques conducted within an angiography suite using two rotating x-ray tubes that acquire x-ray images from a limited number of projection angles and that are processed to provide meaningful diagnostic data.

Abstract: Systems and methods are provided for automated frequency coordination (AFC), by ingesting, at a cloud-based frequency coordination orchestrator, from a mobility conductor (MCR), telemetry data from access points (APs) of a non-cloud managed deployment. The telemetry data can be validated, and a determination can be made as to whether one or more of the APs require AFC. If so, an AFC request for the requisite APs can be scheduled to be forwarded to an AFC server. In response, the AFC server can provide information regarding one or more allowed channels and operating power levels for the requisite APs. The cloud-based frequency coordination orchestrator can concurrently perform AFC operations with respect to APs in a cloud-based AP deployment, making the cloud-based frequency coordination orchestrator universally applicable to both types of AP deployments.

Abstract: The invention describes catheter systems and methods for accessing the brain during endovascular/neurointervention procedures in the treatment of ischemic stroke. More specifically, catheter systems are described that enable quicker and improved access to cerebral vessels as well as improved processes of accessing and aspirating blood clots from the cerebral vessels of a patient with acute ischemic stroke due to medium or large vessel occlusion.

Abstract: Systems and methods for collecting medical data in a pre-hospital setting are described. Modular study devices (MSDs) are comprehensive, customizable toolkits that provide tools/equipment to enable data collection and particularly the tools/equipment to conduct a particular medical study in the pre-hospital setting. Specifically, the equipment and processes allow for standardized data collection and facilitate operating procedures alongside routine clinical care, thereby streamlining study workflow and pre-hospital treatment steps by emergency medical services (EMS) personnel such as paramedics. In addition, systems and methods are described enabling the efficient design of MSDs that may be configured into medical transport vehicles to meet parameters of those vehicles such as volume and/or weight restrictions whilst enabling a customized or unique study protocol to be conducted in the pre-hospital setting.

Abstract: Microcatheters having enlarged distal ends with distally decreasing tapered portions are disclosed. These microcatheters can be used for various treatments within a vessel, such as treatment of a vasospasm and delivery of a liquid embolic material.

Abstract: An obstruction removal device is described. having one or more engaging members which can engage portions of the clot. The one or more engaging members have a collapsed. delivery state, and an expanded. deployed state which in some embodiments can be locked to maintain its fixed configuration.

Abstract: The invention relates to systems and methods for predicting ischemic brain tissue fate from multi-phase CT-angiography. More specifically, systems and methods are provided that enable meaningful prediction of core, penumbra and perfusion from mCTA images using software that has been trained via machine learning to interpret mCTA images.

Abstract: An obstruction removal device is described, having one or more engaging members which can engage portions of the clot. The one or more engaging members have a collapsed, delivery state, and an expanded, deployed state which in some embodiments can be locked to maintain its fixed configuration.

Abstract: The embodiments presented herein relate to concepts designed to eliminate the gap between a catheter and guide wire that can otherwise contribute to a catheter getting stuck within the vasculature.

Abstract: The invention describes catheter systems and methods for accessing the brain during endovascular/neurointervention procedures in the treatment of ischemic stroke. More specifically, a catheter system having a deployable redirection device (RD) is described that improves the process of accessing a clot in a patient with acute ischemic stroke due to large vessel occlusion.

Abstract: Systems and methods for navigation of catheters through vessels including intracranial venous vessel access are described. In addition, systems and methods for the treatment of vasculature conditions including aspiration from the cerebral venous sinus are described. Generally, the system includes a co-axial combination of a microwire, a support catheter having an oval section and an aspiration catheter. Methods of advancing the system through the vasculature including the venous vasculature with narrow sections are also described.

Abstract: The embodiments presented herein relate to concepts designed to eliminate the gap between a catheter and guide wire that can otherwise contribute to a catheter getting stuck within the vasculature.

Abstract: The invention relates to systems and methods to assist physicians in decision making for stroke patients. In particular the systems and methods can be used to assist physicians to decide on whether a patient with an acute ischemic stroke has a large vessel occlusion (LVO) and should be transferred from a community hospital to a larger hospital to undergo an endovascular thrombectomy procedure.

Abstract: Systems and methods for accessing small arteries for conveying catheters to target vessels such as brain vessels are described including systems enabling a catheter to be introduced directly through a vessel opening without an external sheath wherein a distal tip of the catheter is protected by a protective cover. Methods of introducing catheters into vessels and kits are also described.

Abstract: The embodiments presented herein relate to concepts designed to eliminate the gap between a catheter and guide wire that can otherwise contribute to a catheter getting stuck within the vasculature. In an example embodiment, a microcatheter with an enlarged distal section is described. The enlarged portion of the microcatheter may be located close to the inner diameter of the guide catheter in order to reduce any open space between the microcatheter and the guide catheter, and the guidewire can be placed through the microcatheter and used to guide the system. The microcatheter can include one or more marker bands to aid in aligning the microcatheter correctly relative to the guide catheter. After the guide catheter and microcatheter are tracked to the appropriate treatment site, the microcatheter can then be used to deploy various medical devices to treat a patient.

Abstract: An obstruction removal device is described, having one or more engaging members which can engage portions of the clot. The one or more engaging members have a collapsed, delivery state, and an expanded, deployed state which in some embodiments can be locked to maintain its fixed configuration.

Abstract: The invention describes catheter systems and methods for accessing the brain during endovascular/neurointervention procedures in the treatment of ischemic stroke. More specifically, a multi-axial catheter system and kit is described that improves the process of accessing a carotid artery particularly in patients having a tortuous aortic arch and thereafter improves the process of gaining access to the brain to enable the insertion of aspiration and/or the deployment clot retrieval devices. In addition, methods of utilizing these systems are described.