Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.

Abstract: A bacterial toxin protein such as a Shiga toxin protein is efficiently produced using plant cells. The plant cells are transformed using a DNA construct containing DNA encoding a hybrid protein in which the bacterial toxin proteins such as the Shiga toxin proteins are tandemly linked through a peptide having the following characteristics (A) and (B) to produce the bacterial toxin protein in the plant cells: (A) a number of amino acids is 12 to 30; and (B) a content of proline is 20 to 35%.

Abstract: A bacterial toxin protein such as a Shiga toxin protein is efficiently produced using plant cells. The plant cells are transformed using a DNA construct containing DNA encoding a hybrid protein in which the bacterial toxin proteins such as the Shiga toxin proteins are tandemly linked through a peptide having the following characteristics (A) and (B) to produce the bacterial toxin protein in the plant cells: (A) a number of amino acids is 12 to 30; and (B) a content of proline is 20 to 35%.

Abstract: A technology for producing a pig edema disease vaccine at low cost and at high efficiency is developed. Specifically, a gene of a pig edema disease toxin protein (Stx2e protein) is efficiently expressed in plant cells to produce a plant vaccine for pig edema disease at low cost. An Stx2e protein including a secretory signal peptide derived from a plant added at an amino terminus is expressed in cells of a plant such as Lactuca sativa using the 5?-untranslated region of an alcohol dehydrogenase gene (ADH5?UTR) derived from a plant.

Abstract: Peptide which is obtained by treating fish meat such as sardine with an alkaline protease is adsorbed with a peptide-adsorbing resin (such as ODS resin) and eluted with 10 aqueous ethanol to obtain a peptide (Y-2 fraction). The resulting novel peptide has an excellent hypotensive action and can be used as a nutrient and a specific health food and, in addition, it can be advantageously used as a hypotensive agent.

Abstract: The invention relates to an endothelin antagonistic peptide of the formula (I): X-A-Trp-B-Gly-Thr-E-G-Y   (I) SEQ ID NO: 2 wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X1-Gly or  and Y represents hydroxy, lower alkoxy, amino, wherein X1, X3, Y1, Y2 and Z are further defined, or a pharmaceutically acceptable salt thereof.

Abstract: Peptide which is obtained by treating fish meat such as sardine with an alkaline protease is adsorbed with a peptide-adsorbing resin (such as ODS resin) and is eluted with a 10% aqueous ethanol to obtain a peptide (Y-2 fraction).

Abstract: Disclosed in a peptide represented by the following formula (I):

Abstract: There is disclosed a heat resistant cloth for fire fighting. At least an inner surface of a fluororesin film is subjected to plasma discharge treatment to form a treated surface. A vacuum-deposition film made of a bright metal such as aluminum is formed on the treated surface of the fluororesin film without use of a primer. The vacuum-deposition film on the treated surface is bonded to an outer surface of a substrate fabric through use of a silicone rubber adhesive in order to form a heat-reflecting layer on the outer surface of the substrate fabric. Since no primer coating layer is used, the heat reflecting layer can prevent a decrease in brightness, which would otherwise occur due to cracks generated in the primer coating layer. Thus, a decrease in heat reflectivity at high temperature is prevented. Since no flammable synthetic resin layer is used at the surface of the heat reflecting layer, flame resistance can be improved.

Abstract: The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.

Abstract: A contact type image transferring device and method incorporated in an image forming apparatus for cleaning a residual toner on a transfer roller. The transfer roller is in contact with a photoconductive drum at a first force and forms nip between the roller and the drum. A sheet of paper passes through the nip and a toner image on the drum is transferred to the sheet of paper. When the sheet of paper is not at the nip, the transfer roller is moved such that the force of the roller against the drum is a second force which is different from the first force. A cleaning bias voltage is applied to the roller and toner on the roller is transferred to the drum.

Abstract: There is provided an image forming device capable of preventing smudges on the background of an image due to excess toner replenishment caused by a failure in stirring developer and toner enough to charge the toner or scattering of replenished toner without being charged. A toner conveying member for conveying replenished toner from a toner replenishing portion through a toner replenishing port to a developer stirring and conveying member is constructed by a screw member unitarily formed with the developer stirring and conveying member. The screw member has a spiral conveying fin capable of conveying the replenished toner at relatively high speed. The replenished toner is delivered to a toner replenishing portion provided in the upstream of a developer receiving portion of the screw member.

Abstract: A contact type image transferring system and method, incorporated in an image forming apparatus, for cleaning a residual toner on a transfer roller. The transfer roller is in contact with a photoconductive drum and forms a nip between the roller and the drum. A sheet of paper passes through the nip and a toner image on the drum is transferred to the sheet of paper. When the sheet of paper is not at the nip, not only a transfer voltage but also a charging voltage is applied at a same time. The polarities of the voltages applied to the charger and to the transfer roller cause the toner on the transfer roller to be removed.

Abstract: The present invention relates to compound LK6-A represented by the formula: ##STR1## which has immunosuppressive activity, and pharmaceutically acceptable salts thereof.

Abstract: An image forming apparatus capable of collecting a toner remaining on an image carrier after image transfer and conveying the collected toner to a developing unit to reuse it. A toner supplement roller and a toner conveyor are so controlled as to maintain the supplement of a fresh toner from a hopper to the developing unit and the supplement of the collected toner from the toner conveyor to the developing unit in a ratio lying in a predetermined range.

Abstract: The present invention relates to EI-1941 compounds having interleukin-1 production inhibitory activity which are represented by the formula: ##STR1## wherein either of R.sup.1 and R.sup.2 is hydrogen and the other is hydroxy, or R.sup.1 and R.sup.2 together represent oxygen; and R.sup.3 is hydroxy and R.sup.4 is hydrogen, or R.sup.3 and R.sup.4 together represent --0--.

Abstract: Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 represents hydroxy;and Z represents, in case of (1),Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z.sup.1Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1,Trp-Phe-Phe-Asn-Tyr-R-T-Z.sup.1wherein Z.sup.1 is an organic moiety,wherein R is Tyr or a covalent bond,T is Trp, Ala, Phe, Tyr, Trp-Trp, Asn-Tyr-Tyr-Trp, Trp-Asn-Tyr-Tyr-Trp, Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp,or in case of (2), Z representsTrp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1.

Abstract: An image forming apparatus capable of collecting a toner remaining on an image carrier after image transfer and conveying the collected toner to a developing unit to reuse it. A toner supplement roller and a toner conveyor are so controlled as to maintain the supplement of a fresh toner from a hopper to the developing unit and the supplement of the collected toner from the toner conveyor to the developing unit in a ratio lying in a predetermined range.

Abstract: An image forming apparatus capable of collecting a toner remaining on an image carrier after image transfer and conveying the collected toner to a developing unit to reuse it. A toner supplement roller and a toner conveyor are so controlled as to maintain the supplement of a fresh toner from a hopper to the developing unit and the supplement of the collected toner from the toner conveyor to the developing unit in a ratio lying in a predetermined range.

Abstract: A novel physiologically active substance is represented by the formula. ##STR1## The substance is preferably derived from propolis, has excellent antitumor activity and is useful as an antitumor drug.