Patents by Inventor Mazen Es-Sayed

Mazen Es-Sayed has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
    Publication number: 20050070541
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Application
    Filed: August 20, 2004
    Publication date: March 31, 2005
    Applicant: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jorg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski
  • 7-Aikyl and cycloalkyl-substituted imidazotriazinones
    Publication number: 20050049250
    Abstract: The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
    Type: Application
    Filed: May 20, 2004
    Publication date: March 3, 2005
    Applicant: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn
  • Novel imidazo[1,3,5]triazinones and their use
    Publication number: 20050043303
    Abstract: The invention relates to imidazo[1,3,5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases.
    Type: Application
    Filed: July 15, 2004
    Publication date: February 24, 2005
    Applicant: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • 7-alkyl-and cycloalkyl-substituted imidazotriazinones
    Patent number: 6838459
    Abstract: The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: January 4, 2005
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn
  • Imidazo[1,3,5]triazinones and the use thereof
    Patent number: 6803365
    Abstract: The invention relates to imidazo[1.3.5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: October 12, 2004
    Assignee: Bayer Aktlengesellschaft
    Inventors: Ulrich Niewöhner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Isoxazolo pyrimidinones and the use thereof
    Patent number: 6777416
    Abstract: The invention relates to novel isoxazolo pyrimidinones of general formula (I), a method for producing the same and the pharmaceutical use thereof.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: August 17, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Pyrazolyl pyrimidines
    Publication number: 20040102465
    Abstract: This invention relates to novel pyrazolylpyrimidines of the formula 1
    Type: Application
    Filed: December 11, 2003
    Publication date: May 27, 2004
    Inventors: Rudiger Fischer, Bernd Alig, Thomas Bretschneider, Mazen Es-Sayed, Christoph Erdelen, Peter Losel, Udo Reckmann
  • Novel imidazotriazinones and the use thereof
    Publication number: 20040097498
    Abstract: Novel imidazotrizinones of general formula (I), a method for the production and the pharmaceutical use thereof are disclosed.
    Type: Application
    Filed: February 6, 2003
    Publication date: May 20, 2004
    Inventors: Ulrich Niewohner, Maria Niewohner, Mazen Es-Sayed, Thomas Lampe, Helmut Haning, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn
  • Pyridyl pyrimidines for use as pesticides
    Publication number: 20040077641
    Abstract: Novel pyridylpyrimidines of the formula 1
    Type: Application
    Filed: August 19, 2003
    Publication date: April 22, 2004
    Inventors: Thomas Bretschneider, Mazen Es-Sayed, Rudiger Fischer, Fritz Maurer, Christoph Erdelen, Peter Losel
  • 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
    Publication number: 20040067945
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Application
    Filed: February 12, 2003
    Publication date: April 8, 2004
    Inventors: Ulrich Niewohner, Maria Niewohner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jorg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski
  • Triazolotriazinones and the use thereof
    Patent number: 6683081
    Abstract: The invention relates to novel triazolotriazinones of the general formula (I), to a method for their production and to the pharmaceutical use thereof.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: January 27, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • N-(3-benzofuranyl)urea-derivatives
    Patent number: 6677372
    Abstract: N-(3-benzofuranyl)urea-derivatives are prepared by reacting of 3-amino-substituted benzofuranes with appropriate substituted isocyanates or isothiocyanates. The N(3-benzofuranyl)urea-derivatives can be used as active ingredients in medicaments particularly for the treatment of acute and chronic inflammatory processes.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: January 13, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gabriele Bräunlich, Rüdiger Fischer, Mazen Es-Sayed, Rolf Henning, Michael Sperzel, Karl-Heinz Schlemmer, Ulrich Nielsch, Stephen Tudhope, Graham Sturton, Trevor S. Abram, Mary F. Fitzgerald
  • Triazolotriazinones and the use thereof
    Publication number: 20030212064
    Abstract: The invention relates to novel triazolotriazinones of the general formula (I), to a method for their production and to the pharmaceutical use thereof.
    Type: Application
    Filed: October 21, 2002
    Publication date: November 13, 2003
    Inventors: Ulrich Niewohner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Novel imidazo[1,3,5]triazinones and the use thereof
    Publication number: 20030195210
    Abstract: The invention relates to novel imidazo[1,3,5]triazinones of the general formula (I), to a method for their production and to their use as medicaments, in particular as inhibitors of cyclic GMP metabolising phosphodiesterases.
    Type: Application
    Filed: November 4, 2002
    Publication date: October 16, 2003
    Inventors: Ulrich Niewhner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Tan-1057 derivatives
    Patent number: 6617332
    Abstract: The invention relates to novel natural product derivatives of the formula (I), to processes for their preparation, to pharmaceutical compositions comprising them and to their use in the treatment of disorders in humans or animals: in which R1, D, X, Y and Z are defined as in claim 1.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: September 9, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Brands, Mazen Es-Sayed, Dieter Häbich, Siegfried Raddatz, Joachim Krüger, Rainer Endermann, Reinhold Gahlmann, Hein-Peter Kroll, Frank-Ulrich Geschke, Armin de Meijere, Vladimir N. Belov, Victor Sokolov, Sergej Kozhushkov, Markus Kordes
  • Benzofuranylsulfonates
    Patent number: 6610687
    Abstract: The invention relates to benzofuranylsulfonates of the general formula (I), their preparation and their use for the treatment of inflammation.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: August 26, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gabriele Bräunlich, Mazen Es-Sayed, Rüdiger Fischer, Burkhard Fugmann, Rolf Henning, Stephan Schneider, Michael Sperzel, Karl-Heinz Schlemmer, Graham Sturton, Mary F. Fitzgerald, Barbara Briggs, Arnel Concepcion, William Bullock
  • Isoxazolo pyrimidinones and the use thereof
    Publication number: 20030149033
    Abstract: The invention relates to novel isoxazolo pyrimidinones of general formula (I), a method for producing the same and the pharmaceutical use thereof.
    Type: Application
    Filed: October 22, 2002
    Publication date: August 7, 2003
    Inventors: Ulrich Niewohner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • N-(3-benzofuranyl)urea-derivatives
    Publication number: 20030109578
    Abstract: N-(3-benzofuranyl)urea-derivatives are prepared by reacting of 3-amino-substituted benzofuranes with appropriate substituted isocyanates or isothiocyanates. The N(3-benzofuranyl)urea-derivatives can be used as active ingredients in medicaments particularly for the treatment of acute and chronic inflammatory processes.
    Type: Application
    Filed: May 24, 2002
    Publication date: June 12, 2003
    Inventors: Gabriele Braunlich, Rudiger Fischer, Mazen Es-Sayed, Rolf Henning, Michael Sperzel, Karl-Heinz Schlemmer, Ulrich Nielsch, Stephen Tudhope, Graham Sturton, Trevor S. Abram, Mary F. Fitzgerald
  • 2-phenyl substituted imidatriazinones as phosphodiesterase inhibitors
    Patent number: 6566360
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: May 20, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jörg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski
  • 7-alkyl- and cycloalkyl-substituted imidazotriazinones
    Patent number: 6476029
    Abstract: The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: November 5, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn