Abstract: The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.

Abstract: A fluid testing system can be used to measure the levels of contaminants in a fluid system. The system can utilize anodic stripping voltammetry or some other chemical, electrical, or electrochemical process to measure the contaminant levels. Wire electrodes may be used to facilitate the tests. Unused portions of the electrode wires can be fed into the test chambers between tests to ensure clean and reliable electrodes for subsequent testing.

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling blood glucose levels in patients. In particular, times for obtaining metered blood glucose samples of a patient may be altered based, at least in part, on a blood glucose level of said patient observed from a blood glucose sensor.

Abstract: Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing the underlying trend. Other example embodiments are disclosed herein.

Abstract: A water usage monitor can include a housing having a fluid flow path, a fluid inlet in fluid communication with the fluid flow path, and a fluid outlet in fluid communication with the fluid flow path. The housing can include a dry housing interior fluidly isolated from the fluid flow path. The monitor preferably includes a power generator configured to generate a voltage when fluid flows through the fluid flow path and at least one sensor configured to measure at least one characteristic of a fluid flowing through the fluid flow path. The monitor can include a signal generator configured transmit signals from the power generator and from the at least one sensor to a remote processor. The power generator can be configured to power both the at least one sensor and the signal generator in response to fluid flow through the fluid flow path.

Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).

Abstract: A water usage monitor can include a housing having a fluid flow path, a fluid inlet in fluid communication with the fluid flow path, and a fluid outlet in fluid communication with the fluid flow path. The housing can include a dry housing interior fluidly isolated from the fluid flow path. The monitor preferably includes a power generator configured to generate a voltage when fluid flows through the fluid flow path and at least one sensor configured to measure at least one characteristic of a fluid flowing through the fluid flow path. The monitor can include a signal generator configured transmit signals from the power generator and from the at least one sensor to a remote processor. The power generator can be configured to power both the at least one sensor and the signal generator in response to fluid flow through the fluid flow path.

Abstract: Methods, systems, apparatuses, and computer program products are provided for developing, debugging, and growing workflows. Embodiments enable the developer to test the workflow in place in a workflow designer that displays input/output parameter values for each workflow step during the test run. The developer is enabled to toggle the workflow step(s) between a development mode, where the developer may edit input parameter values, and a test mode, where the developer is displayed (but cannot edit) the input parameter values and is displayed the output parameter values at each workflow step. A record of workflow runs of a workflow is also maintained. The developer is also enabled to transition a workflow from being a business application to a robust software application having additional functionality. The workflow logic generated is transported between a visual workflow designer and a full-blown code editor.

Abstract: Disclosed is a passwordless electronic mail (e-mail) communication method and system. The method includes receiving a cell phone number inputted by a user over a user communication device for registering the user with a server hosting a passwordless email service website with a domain name, sending a SMS message including a verification code to the user using Hypertext Preprocessor (PHP) APIs, authenticating the user communication device using the received verification code, and in response to a successful authentication of the user communication device of the user: converting the received cell phone number into a predefined text email address containing the cell phone number and the domain name, and facilitating the user with transmission and reception of e-mails globally, to and from another user using the converted predefined text email address.

Abstract: Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.

Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).

Abstract: The present investigation relates to a conjugate comprising flagellin adjuvant covalently linked to Vi polysaccharide derived from S. typhi for vaccination against typhoid. Both flagellin adjuvant and Vi polysaccharide are from S. typhi which leads to the improved immunogenicity. The conjugate of the present invention can be used as single dose administration without the need of multiple immunizations. The present invention also discloses a nanoparticle composition comprising the conjugate of the present invention.

Abstract: The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.

Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Abstract: Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation of lysophosphatidic acid receptor 1. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Abstract: The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

Abstract: This disclosure relates generally to contract management, and more particularly to contract management in a data marketplace. In an embodiment, a system for contract management performs refactoring of a contract, during which the system extracts terms and conditions from the contract and generates a simplified view of the contract. The system further performs a requirement validation based on the contract, during which the system determines features of data entity matches requirements specified by a first party or not, based on domain specific ontologies. If the data entity features are not matching with the requirements, then the system fetches one or more relevant attributes from a list of ontologies, verifies whether the features of entity along with the selected feature(s) satisfy the requirements or not. The system accordingly generates an agreeable requirement document as output of the requirement validation.

Abstract: A water usage monitor can include a housing having a fluid flow path, a fluid inlet in fluid communication with the fluid flow path, and a fluid outlet in fluid communication with the fluid flow path. The monitor can include a controllable valve and a diverter that can accommodate a plurality of different types of sensors. The housing can include a dry housing interior fluidly isolated from the fluid flow path. The monitor preferably includes a power generator configured to generate a voltage when fluid flows through the fluid flow path and at least one sensor configured to measure at least one characteristic of a fluid flowing through the fluid flow path. The monitor can include a signal generator configured transmit signals from the power generator and from the at least one sensor to a remote processor. The power generator can be configured to power both the at least one sensor and the signal generator in response to fluid flow through the fluid flow path.

Abstract: An apparatus can be provided which can include a laser arrangement which can be configured to provide a laser radiation, and can include an optical cavity. The optical cavity can include a dispersive optical first arrangement which can be configured to receive and disperse at least one first electro-magnetic radiation so as to provide at least one second electro-magnetic radiation. Such cavity can also include an active optical modulator second arrangement which can be configured to receive and modulate the at least one second radiation so as to provide at least one third electro-magnetic radiation. The optical cavity can further include a dispersive optical third arrangement which can be configured to receive and disperse at least one third electro-magnetic radiation so as to provide at least one fourth electro-magnetic radiation.

Abstract: Exemplary apparatus can be provided which can include a laser arrangement that is configured to provide a laser radiation, and including an optical cavity. The optical cavity can include a dispersive optical waveguide first arrangement having first and second sides, and which is configured to (i) receive at least one first electro-magnetic radiation at the first side so as to provide at least one second electro-magnetic radiation, and (ii) to receive at least one third electro-magnetic radiation at the second side so as to provide at least one fourth electro-magnetic radiation. The first and second sides are different from one another, and the second and third radiations are related to one another. The optical cavity can also include an active optical modulator second arrangement which can be configured to receive and modulate the fourth radiation so as to provide the first electro-magnetic radiation to the first arrangement.