Abstract: The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav 1.7 and/or Nav 1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Abstract: A fluid testing system can be used to measure the levels of contaminants in a fluid system. The system can utilize anodic stripping voltammetry or some other chemical, electrical, or electrochemical process to measure the contaminant levels. Wire electrodes may be used to facilitate the tests. Unused portions of the electrode wires can be fed into the test chambers between tests to ensure clean and reliable electrodes for subsequent testing.

Abstract: A fault monitoring system for an electrical substation includes one or more arrays of acoustic sensors placed around a substation boundary and configured to measure acoustic pressure waves. A processing circuitry in the fault monitoring system localizes and identifies faults in the substation and includes a sound source localization module to identify an area of a sound source based on the acoustic pressure waves. A beamforming module of processing circuitry provides enhanced acoustic pressure waves by eliminating background noise and interfering noise from the acoustic pressure waves and a component signature classification module in the processing circuitry compares enhanced acoustic pressure waves with component signatures to classify the acoustic pressure waves into various events to detect faults in the electrical substation.

Abstract: The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond.

Abstract: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. Aspects of the invention relate to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab).

Abstract: A system for generating eccentering corrected response includes a logging tool configured to examine a material filled in an annular space to generate a tool response. The material is filled in an annular space formed by an outer conduit and an inner conduit disposed in the outer conduit. The logging tool is disposed in an inner conduit. The tool response includes scattered gamma ray photon counts distorted by a radial shift of the logging tool. The system includes a data transmission device coupled to a plurality of detectors and configured to transmit data detected by the plurality of detectors. The system also includes a computer processor linked to the data transmission device and configured to receive the tool response. The computer processor is configured to process the tool response and generate an eccentered corrected response by correcting effects of the radial shift in the tool response using eccentering correction technique.

Abstract: A motor vehicle includes a user interface having a display screen and a loudspeaker. A radio frequency receiver receives a wireless status signal from a traffic light. An electronic processor is communicatively coupled to the radio frequency receiver and determines whether to present content from the status signal to a driver of the vehicle. If it is determined to present content from the status signal to the driver, the content is presented via the display screen and/or the loudspeaker.

Abstract: The catalyst for mild-hydrocracking of residual oil includes a porous alumina support a plurality of transition metals impregnated on the alumina support. The support has a specific surface area greater than 150 m2/g, a total pore volume ranging from about 0.25 ml/g to about 1.5 ml/g, about 20% of the pores having a diameter greater than 150 nm, about 70% of the pores having a diameter ranging from about 2 nm to about 150 nm, and about 10% of the pores having a diameter less than 2 nm. The plurality of transition metals include one Group VIII element and one or more Group VI elements.

Abstract: Systems and methods of the present disclosure provide comprehensive risk assessment in a heterogeneous dynamic network. The framework enables ‘view’ and ‘analyses’ of complete architecture simultaneously in information view, deployment view, business view and security view. Fundamentally, data pertaining to information flow between a plurality of nodes within systems in a network is identified. One or more affected nodes or paths therebetween are identified and attack risk is computed. The graph based framework supports multiple threat models for threat evaluation. It also provides mitigation plans which will reflect reduced risk in the business view and incorporates attack tree simulations to evaluate dynamic behavior of a system under attack.

Abstract: The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

Abstract: An automatic pet wet canned food dispenser robot has a robotic arm comprised of mechanical elements and motors, a can opener and a programmed microprocessor. The programmed microprocessor guides the robotic arm to grasp a food can and utilize the can opener to open the can and invert it and shake out the food contents into a bowl for a pet at predetermined times setup by the pet owner whose presence is not required at time of feeding.

Abstract: A fluid testing system can be used to measure the levels of contaminants in a fluid system. The system can utilize anodic stripping voltammetry or some other chemical, electrical, or electrochemical process to measure the contaminant levels. Wire electrodes may be used to facilitate the tests. Unused portions of the electrode wires can be fed into the test chambers between tests to ensure clean and reliable electrodes for subsequent testing.

Abstract: A parking system and method is disclosed. The system facilitates coordination and communication between users to aid in parking transactions. For instance, one user may wish to occupy the parking spot of another user. The system and method allows users to display parking spots in the system such that they can be viewed by other users, and to request or to book parking spots posted by other users. The system may include an exchange medium in the form of points that can be swapped for parking spots or any other currency or payment method to incentivize the transfer of parking spots between users. The database may include any kind of parking spot from any source, including parking spots posted by other users on streets with free parking.

Abstract: An apparatus can be provided which can include a laser arrangement which can be configured to provide a laser radiation, and can include an optical cavity. The optical cavity can include a dispersive optical first arrangement which can be configured to receive and disperse at least one first electro-magnetic radiation so as to provide at least one second electro-magnetic radiation. Such cavity can also include an active optical modulator second arrangement which can be configured to receive and modulate the at least one second radiation so as to provide at least one third electro-magnetic radiation. The optical cavity can further include a dispersive optical third arrangement which can be configured to receive and disperse at least one third electro-magnetic radiation so as to provide at least one fourth electro-magnetic radiation.

Abstract: The content management application is an intranet application which provides a process for implementing changes to an internet website of a company by providing the company the ability to define and enforce a common style of page layout. The application can be accessed via a desktop browser and multiple users may access the application for multiple reasons at the same time. The application also dynamically generates new page designs and new component design with various people assigned to groups or teams enabling the continuous creation and processing of content. Once the content is created and reviewed, it is then launched onto the company's internet site for viewing by the internet users accessing the company's web page.

Abstract: Methods, systems, apparatuses, and computer program products are provided for developing, debugging, and growing workflows. Embodiments enable the developer to test the workflow in place in a workflow designer that displays input/output parameter values for each workflow step during the test run. The developer is enabled to toggle the workflow step(s) between a development mode, where the developer may edit input parameter values, and a test mode, where the developer is displayed (but cannot edit) the input parameter values and is displayed the output parameter values at each workflow step. A record of workflow runs of a workflow is also maintained. The developer is also enabled to transition a workflow from being a business application to a robust software application having additional functionality. The workflow logic generated is transported between a visual workflow designer and a full-blown code editor.

Abstract: The present invention relates to novel chromone alkaloid of formula 1 isolated from the plant Dysoxylum binectariferum. The compound 5,7-dihydroxy-6-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-one, is found to be a potential inhibitor of cell growth and proliferation and also inhibits production of pro-inflammatory cytokines. The formulations of this particular compound can be used for treatment of cancer and inflammation.

Abstract: The present invention relates to 2,3,4,4a-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyrano[3,2-c]isochromen-6(10bH)-one analogs of the Formula I, wherein, R, R? and R? are as herein described. In addition, the invention relates to methods of using compounds for treating or preventing various inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma and chronic obstructive pulmonary disorder.

Abstract: The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.