Abstract: This invention relates to treatment of cancer using a CD33 antibody drug conjugate in combination with hypomethylating agents.

Abstract: The invention provides a novel filtration apparatus for the selective separation of metals from a mixture thereof. The invention also provides a method for the separation and isolation of metals from a sample using electrochemical precipitation.

Abstract: An end effector for a surgical instrument comprises a first jaw and a second jaw. The first jaw is configured to receive a staple cartridge. The second jaw is movable relative to the first jaw and is configured to provide an anvil for forming staples. The anvil has staple forming pockets. Each staple forming pocket comprises first and second staple forming surface regions configured to receive respective first and second staple legs. The first and second staple forming surface regions each have a respective length that is greater than half of the length of the staple forming pocket. The staple forming surface regions may include convex surfaces that drive staple legs laterally. The pocket minimizes re-entry of staple leg tips into tissue.

Abstract: An apparatus for operating on tissue comprises a body, an elongate shaft, an end effector, a compression member, and a firing beam. The end effector has a pair of jaws configured to open and close along a first plane. The end effector is capable of delivering RF energy to the tissue. The compression member is configured to drive the jaws to a closed position once the compression member has been distally driven into the end effector. The compression member is substantially inflexible along the first plane yet is flexible along a second plane that is transverse to the first plane. The firing beam is operable to sever tissue captured within the end effector. The compression member may be actuated distally to close the jaws upon tissue and provide uniform compression of the tissue along the length of the jaws before the firing beam is advanced through the tissue.

Abstract: A scaffold, a method of using the scaffold and a method of preparing the scaffold which may promote the growth or survival of cells and tissues. The scaffold comprises at least one microvascular layer formed from a thin-film fibrin, the microvascular layer configured to sustain and promote growth of cells and having one or more microfluidics channels embedded in the microvascular layer, the channels configured to contain nutrients needed for growth of the cells, and the channels configured to permit diffusion of the nutrients from the channels to the cells.

Abstract: A kit to facilitate identifying at least one glove particularly suitable to be worn by a particular individual includes a backdrop having at least two visually-discernible calibration marks disposed thereon, a camera, a memory having stored therein characterizing parameters for a variety of different gloves, and a control circuit that operably couples to the latter. The control circuit presents to a kit user via a display an image of the particular individual's hand as placed on the backdrop, and then presents a plurality of user-placeable markers by which the kit user marks particular locations of the particular individual's hand. The control circuit then processes the image of the particular individual's hand as marked by the kit user and as a function of the two visually-discernible calibration marks to identify at least one glove that is particularly suitable to be worn by the particular individual.

Abstract: A method for treating a subject having a diseased or atrophic state of fibrotic tissue, kidney disease and associated nerve endings, or for promoting tissue regeneration in muscle tissue is accomplished through exposing the tissue with a laser light having a wavelength of about 400 nm to about 700 nm, or more preferably having a wavelength of about 405 nm, about 532 nm, about 635 nm, or a combination thereof. Subsequent to exposure, mesenchymal stem cells can be administered to the subject. After the administration of mesenchymal stem cells, the tissue is further exposed to laser light having a wavelength of about 400 nm to about 700 nm, or a laser light having a single wavelength of about 400 nm to about 700 nm. The mesenchymal cells can be interferon gamma activated.

Abstract: The conductive polymer films of this disclosure reversibly and selectively mediate ligand-receptor interactions. This electrochemical manipulation of biochemical interactions is accomplished by embedding or adsorbing receptors for ligands of interest in or onto a conductive polymer matrix. The matrix can also be doped, for example, with desired ions, polyions, or surfactants. Depending on the receptor properties and dopants utilized, ligand-receptor interactions at the polymer-electrolyte interface are manipulated by controlling the oxidation and reduction of the conductive polymer. The intrinsic charge transfer characteristics of conductive polymers are used to modulate ligand-receptor interactions.

Abstract: The present invention provides porous electroactive hydrogels, the deformation angle of which is controlled by electroactuation, and methods for preparing and using such hydrogels.

Abstract: A product package is presented that has a sliding tray disposed within a sleeve. Both the sleeve and the tray have a tab on their top portions through which is positioned a hang-hole. The hang-holes in these two tabs align when the tray is inserted into the sleeve, allowing a display hanger to pass through the hole in both tabs. The tray also has a structure with an overhang portion that extends beyond a side wall of the tray. The overhang portion is positioned to abut the edge of the sleeve when the tray is fully inserted into the sleeve to prevent the tray from passing too far into, or even through the sleeve.

Abstract: An apparatus for operating on tissue comprises a body, an elongate shaft, an end effector, a compression member, and a firing beam. The end effector has a pair of jaws configured to open and close along a first plane. The end effector is capable of delivering RF energy to the tissue. The compression member is configured to drive the jaws to a closed position once the compression member has been distally driven into the end effector. The compression member is substantially inflexible along the first plane yet is flexible along a second plane that is transverse to the first plane. The firing beam is operable to sever tissue captured within the end effector. The compression member may be actuated distally to close the jaws upon tissue and provide uniform compression of the tissue along the length of the jaws before the firing beam is advanced through the tissue.

Abstract: An end effector for a surgical instrument comprises a first jaw and a second jaw. The first jaw is configured to receive a staple cartridge. The second jaw is movable relative to the first jaw and is configured to provide an anvil for forming staples. The anvil has staple forming pockets. Each staple forming pocket comprises first and second staple forming surface regions configured to receive respective first and second staple legs. The first and second staple forming surface regions each have a respective length that is greater than half of the length of the staple forming pocket. The staple forming surface regions may include convex surfaces that drive staple legs laterally. The pocket minimizes re-entry of staple leg tips into tissue.

Abstract: Disclosed herein are biochemical actuator heads instrumented with a receptor conductive polymer for reversibly controlling ligand-receptor interactions. Also disclosed are systems and methods for utilizing and fabricating the biochemical actuator head. The biochemical actuator head and related systems and methods may be used in a wide array of applications including, without limitation, micro/nano assembly, examination of cellular signaling mechanisms, image-guided cell nanosurgery or particle processing. Particle processing systems and methods are also provided utilizing a receptor conductive polymer for reversibly controlling ligand-receptor interactions.

Abstract: A product package is presented that has a sliding tray disposed within a sleeve. Both the sleeve and the tray have a tab on their top portions through which is positioned a hang-hole. The hang-holes in these two tabs align when the tray is inserted into the sleeve, allowing a display hanger to pass through the hole in both tabs. The tray also has a structure with an overhang portion that extends beyond a side wall of the tray. The overhang portion is positioned to abut the edge of the sleeve when the tray is fully inserted into the sleeve to prevent the tray from passing too far into, or even through the sleeve.

Abstract: The present invention provides porous electroactive hydrogels, the deformation angle of which is controlled by electroactuation, and methods for preparing and using such hydrogels.

Abstract: The conductive polymer films of this disclosure reversibly and selectively mediate ligand-receptor interactions. This electrochemical manipulation of biochemical interactions is accomplished by embedding or adsorbing receptors for ligands of interest in or onto a conductive polymer matrix. The matrix can also be doped, for example, with desired ions, polyions, or surfactants. Depending on the receptor properties and dopants utilized, ligand-receptor interactions at the polymer-electrolyte interface are manipulated by controlling the oxidation and reduction of the conductive polymer. The intrinsic charge transfer characteristics of conductive polymers are used to modulate ligand-receptor interactions.