Abstract: The present invention relates to an aircraft, missile, projectile, or underwater vehicle with an improved control system and an improved control system for maneuvering an aircraft, missile, projectile, or underwater vehicle. More particularly, the present invention relates to an aircraft, missile, underwater vehicle or projectile with removable control surfaces. The technical advantage of the removable control surface system (or “removable control surface”) over other systems is that the removable control surface system enables the aircraft, missile, underwater vehicle or projectile to have two or more design configurations, each configuration being tailored to the aircraft, missile, projectile, or underwater vehicle's specific stability or maneuverability requirements during a specific portion of the flight.

Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.

Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.

Abstract: A memory manager acts on a memory that has been arranged with a predetermined number of fixed memory blocks, with each memory block set to a predefined size. These fixed blocks have been initialized to accelerate the allocation process. When a memory manger receives an allocation request, the size of the request is compared to the predefined size. If the memory manager determines that the fixed memory block handles the memory request, then the memory manager allocates one of the fixed blocks to the pending memory request. If no fixed block is available to handle the request, then the memory manager may allocate the memory from a free memory pool. The memory manager may search the available free memory blocks to identify and allocate the optimum free block that satisfies the pending allocation request.

Abstract: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.

Abstract: The present invention relates to an aircraft, missile, projectile, or underwater vehicle with an improved control system and an improved control system for maneuvering an aircraft, missile, projectile, or underwater vehicle. More particularly, the present invention relates to an aircraft, missile, underwater vehicle or projectile with removable control surfaces. The technical advantage of the removable control surface system (or “removable control surface”) over other systems is that the removable control surface system enables the aircraft, missile, underwater vehicle or projectile to have two or more design configurations, each configuration being tailored to the aircraft, missile, projectile, or underwater vehicle's specific stability or maneuverability requirements during a specific portion of the flight.

Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

Abstract: The present invention relates to a method of controlling an aircraft, missile, munition or ground vehicle with plasma actuators, and more particularly to controlling fluid flow across their surfaces or other surfaces, which would benefit from such a method. The method includes the design of an aerodynamic plasma actuator for the purpose of controlling airflow separation over a control surface of a aircraft, missile, or a ground vehicle, and more particularly to the method of determining a modulation frequency for the plasma actuator for the purpose of fluid flow control over these vehicles. The various embodiments provide the steps to increase the efficiency of aircraft, missiles, munitions and ground vehicles. The method of flow control provides a means for reducing aircraft, missile's, munition's and ground vehicle's power requirements. These methods also provide alternate means for aerodynamic control using low-power hingeless plasma actuator devices.

Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

Abstract: According to one embodiment, an apparatus and method for delivering one or more fluids to a microfluidic channel is provided. A microfluidic channel is provided in communication with a first conduit for delivering fluids to the microfluidic channel. Further, the apparatus and method can include a first fluid freeze valve connected to the first conduit and operable to reduce the temperature of the first conduit for freezing fluid in the first conduit such that fluid is prevented from advancing through the first conduit.

Abstract: Methods for characterizing a biochemical reaction and analysis of reaction products by establishing continuously variable concentration gradients of one or more reagents of the biochemical reaction are provided. Methods for determining mechanism of inhibition or activation, potency of inhibition or activation, or both of an enzyme inhibitor or activator, respectively, are also provided. The continuously variable concentration gradients can be established in a microfluidic chip.

Abstract: Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/mm range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.

Abstract: Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

Abstract: A system and method for auto-calibrating a barcode scanning tunnel to determine the orientation of one or more cameras with respect to a range finder and a conveyor belt comprises providing a scanning tunnel having a moveable surface, at least one range finder having an orientation, at least one camera having an orientation and at least one calibration object having at least one indicia disposed in a predetermined relationship to one or more features of the at least one calibration object, capturing at least one image of the at least one calibration object by the at least one camera, electronically detecting the at least one calibration object at least one indicia and the one or more object features and electronically calculating at least one component of the at least one camera orientation with respect to the moveable surface in response to information obtained from the image and the at least one calibration object at least one indicia.

Abstract: The pumps (Pn) are operated to transport individual reagent streams into the chip in a non-pulsatile, laminar flow regime at low flow rates permitting lows grading from 0 to as little as 5 nl/min with a precision of 0.1 nl/min. In the chip (MFC), the reagent streams are merged and the reagents mixed to form a reaction product. The reaction product can be measured at one or more detection points defined in the chip. Concentration gradients are continuously varied by continuously varying the flow rates respectively produced by the pumps according to predetermined flow velocity profiles.

Abstract: A system and method for reading an optical code is provided. The optical code reader system includes a dual aim/illumination assembly including a single light source generating: a) light having a first intensity for providing an aim pattern visible to a user for aiming the aim pattern at a target during an aim period of a scan cycle having at least an aim period and an exposure period; and b) light having a second intensity greater than the first intensity for providing illumination during the exposure period of the scan cycle. An imager module having an array of photo sensors senses incident light and generating image signals corresponding to the sensing during the exposure period.

Abstract: A system and method for performing a read operation including acquiring a series of frames of image data; processing a first frame of image data including an array of pixel data acquired while an aiming pattern was generated for determining a location L of at least one pixel of the array of pixel data that corresponds to the aiming pattern; and processing a second frame of image data acquired while the aiming pattern was not generated. The processing of the second frame of image data includes the steps of selecting at least one optical code acquired in the second frame of image data that is located at a respective location; wherein the respective location meets a predetermined condition relative to the determined location L; and providing the selected at least one optical code for further processing in accordance with the read operation.

Abstract: Methods and apparatus for swipe image scanning comprising a scan stand and an imaging scanner. An exemplary scan stand comprises an illumination module and a receiving structure to receive the imaging scanner. Other embodiments further comprise a scan module, an illumination module, a processing unit, a detection component and memory. In an embodiment, the scan stand illuminates target dataforms brighter than the illumination from the scanner allowing for shorter exposure times and improved scanner performance.

Abstract: A modular camera having a chassis module, a camera module, an illumination module and a communications module that together form a cooling passageway. The chassis module has a back wall having a first end and an opposite second end, a bottom wall having at least one opening formed therein, a first fan mounted at the chassis back wall first end, and a second fan mounted at the chassis back wall second end. The camera module has a body, wherein the camera body is removably received through a hole formed through the chassis module back wall. The illumination module has a back wall, wherein the illumination module is removably coupled to the chassis module so that the illumination module back wall is spaced apart from the chassis module back wall. The communication module is removably coupled to the chassis module. The chassis module back wall, the camera module body, the illumination module back wall and the communications module together form a cooling channel.

Abstract: A bar code scanning system and method for reading and processing bar code symbology uses a scanning station installed above the check-out stand and a receiving station at some distance away from the scanning station. The scanning station projects light onto a surface of the check-out stand. The projected light can have a well defined border indicating where a user should place items to be scanned. Alternatively, a pattern coincident with the projected light can be projected onto the surface and which includes a target indicating where items should be placed for scanning. Light reflected by items in the target region is processed to decode optical symbology on the item and produce a signal that is representative of said sensed symbology. Information about the scanned item can be processed and displayed by the receiving station for use in, e.g., a point-of-sale transaction.