Patents by Inventor Mei Zhang
Mei Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12214394Abstract: A mold for preparing large-size rare earth magnesium alloy ingot without tail shrinkage by back pressure plastic deformation includes a male mold, a female mold, a recoverable discard block and a back pressure plate connected with a pushing cylinder of the press machine. The female mold is provided with an upper mold cavity and a lower mold cavity, an upper part of the upper mold cavity is configured for placing blanks, the recoverable discard block and the male mold, and a lower part of the upper mold cavity is inclined inward to form an extrusion deformation area. The recoverable discard block is configured to be deformed to fill an extrusion deformation area and subsequently restored into the initial state of the recoverable discard block.Type: GrantFiled: September 14, 2022Date of Patent: February 4, 2025Assignee: Shanxi Zhongbei Ruizhi Jingcheng Technology Co., Ltd.Inventors: Zhimin Zhang, Jianmin Yu, Mei Cheng, Zhe Chen, Zhen Wang
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Patent number: 12208365Abstract: A gene chip includes a chip carrier, a plurality of DNA nanoballs assembled on the chip carrier, and a polymer film formed on the chip carrier and wrapping the DNA nanoballs. The polymer film includes at least one of a film of a positively charged polymer, a film of a positively charged polymer which is modified, a film of a zwitterionic polymer, and a composite polymer film. The composite polymer film is formed by a layer-by-layer self-assembly process of a positively charged polymer and a negatively charged polymer. The gene chip has good sequencing quality and different functions can be achieved by coating with different polymers, such as the chip surface rapidly drying out and surface non-specific adsorption. A method of preparing a gene chip is further disclosed.Type: GrantFiled: August 15, 2018Date of Patent: January 28, 2025Assignee: BGI SHENZHENInventors: Zhao-Hui Wang, Hui Wang, Cheng-Mei Xing, Han-Dong Li, Wen-Wei Zhang, Jay Willis Shafto, Mei-Hua Gong, Jin Yang, Yin-Ling Luo, Zhen-Hua Zhang, Yuan Li, Xue-Qin Jiang
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Publication number: 20250011272Abstract: A long-chain compound, a preparation method therefor and the use thereof are disclosed. The structure of said compound is represented by formula (I). The definition of each substituent in the formula is as set out in the description and claims. The compound can directly inhibit ACLY, inhibit lipid synthesis in primary hepatocytes, inhibit lipid de novo synthesis and histone acetylation in various cancer cells such as H358, and inhibit cancer cell proliferation. The compound may be used to prepare drugs that treat metabolic diseases such as hyperlipidemia and atherosclerosis or various cancers such as lung cancer, pancreatic cancer, breast cancer, ovarian cancer, liver cancer, intestinal cancer, brain cancer, and acute myeloid leukemia.Type: ApplicationFiled: September 21, 2022Publication date: January 9, 2025Inventors: Fajun NAN, Jingya LI, Yi CHEN, Gaolei SONG, Zhifu XIE, Yanfen FANG, Mei ZHANG, Xinyu SUN, Lei CAO, Hui MA, Yurou YANG
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Patent number: 12190253Abstract: A system according to which a network of physical sensors are configured to detect and track the performance of aircraft engines. The physical sensors are placed in specific locations to detect an exhaust gas temperature, vibration, speed, oil pressure, and fuel flow for each aircraft engine. The performance of each aircraft engine is then viewed in combination with oil consumption associated with that aircraft engine and the routine maintenance program associated with that aircraft engine to route the aircraft and move the aircraft, in accordance with the routing, to a specific location. The sensors efficiently track the performance and physical condition of the engines. Moreover, a listing of identified “at-risk” engines is displayed on a screen of a GUI in a manner that allows for easy navigation and display. Data point(s) that triggered the identification of each “at-risk” engine are easily accessible and viewable.Type: GrantFiled: June 30, 2023Date of Patent: January 7, 2025Assignee: AMERICAN AIRLINES, INC.Inventors: Ning Xu, Jose Antonio Ramirez-Hernandez, Steven James Oakley, Mei Zhang, Ou Bai, Supreet Reddy Mandala
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Publication number: 20240407235Abstract: A light-emitting module and a display device are disclosed. The light-emitting module includes a substrate, a light-emitting element, and a protective sealant. The protective sealant has a thermal expansion rate that is greater than a thermal expansion rate of the substrate. There is defined a plurality of grooves in a side of the substrate facing the protective sealant. Each groove is disposed between adjacent light-emitting elements.Type: ApplicationFiled: April 22, 2024Publication date: December 5, 2024Inventors: Mei ZHANG, Lidan YE
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Patent number: 12156884Abstract: A method of treating a subject having cancer is described that includes administering a therapeutically effective amount of a ?-(1,3)-(1,4) glucan to the subject. Methods of immunostimulating in a subject by administering an effective amount of a ?-(1,3)-(1,4) glucan to the subject are also described.Type: GrantFiled: February 10, 2021Date of Patent: December 3, 2024Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Mei Zhang, Alex Y. Huang, Julian Kim
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Patent number: 12134636Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.Type: GrantFiled: October 30, 2020Date of Patent: November 5, 2024Assignee: Janssen Pharmaceutica NVInventors: Mark Macielag, Raymond J. Patch, Rui Zhang, Martin A. Case, Mark J. Wall, Yue-Mei Zhang, Shamina M. Rangwala, James N. Leonard, Raul C. Camacho, Michael J. Hunter, Katharine E. D'Aquino, Wilson Edwards, Ronald V. Swanson, Wenying Jian, Ellen Chi
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Patent number: 12137312Abstract: An earphone comprising: a device housing that defines an interior cavity within the device housing; an acoustic port formed through a wall of the device housing; an audio driver disposed within the device housing and aligned to emit sound through the acoustic port; a user input region disposed along an exterior surface of the device housing; a flex circuit disposed within the interior cavity, the flex circuit including a first portion bonded at a first location to an inner surface of the device housing directly beneath the user-input region, a second portion bonded at a second location to an inner surface of the device housing spaced apart from the first location, and a third portion extending between the first and second portions; a force pixel disposed within the interior cavity and mounted to the first portion of the flex circuit below the user input region; a plurality of touch pixels disposed within the interior cavity between the force pixel and the user input region; sensor control circuitry disposed wType: GrantFiled: August 24, 2022Date of Patent: November 5, 2024Assignee: APPLE INC.Inventors: Benjamin A. Cousins, Travis Owens, Karan Jain, Lee M. Panecki, Mei Zhang, Julia Canning
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Patent number: 12111810Abstract: A computer-implemented method includes: collecting, by a computing device, database activities and database structure information of a database; identifying, by the computing device, related columns in the database; determining, by the computing device, one or more data types for column transference of the identified related columns; generating, by the computing device, a super union column based on the column transference and the identified related columns; and updating, by the computing device, the database with the super union column.Type: GrantFiled: March 30, 2022Date of Patent: October 8, 2024Assignee: International Business Machines CorporationInventors: Sheng Yan Sun, Hong Mei Zhang, Peng Hui Jiang, Meng Wan
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Patent number: 12105722Abstract: Provided are techniques for building and using a sparse Time Series Database (TSDB). Time series records are received from a native TSDB, where each of the time series records includes a timestamp and one or more tags. Timeslots are determined for shards for the sparse TSDB based on the timestamp included in each of the time series records. The sparse TSDB is built by creating the shards for the determined timeslots and storing the time series records in the shards, while filling in empty ranges in the shards. A query that specifies at least one of the one or more tags is received. It is determined whether to execute the query against the sparse TSDB, and, in response to a determination to execute the query against the sparse TSDB, the query is executed against the sparse TSDB to generate results that are returned.Type: GrantFiled: August 5, 2022Date of Patent: October 1, 2024Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Peng Hui Jiang, Jun Su, Sheng Yan Sun, Hong Mei Zhang, Meng Wan
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Patent number: 12091419Abstract: A method for preparing dihydroartemisinin bulk drug in single process comprises: S1. dissolving artemisinin in aprotic solvent; S2. adding phase transfer catalyst and reducing agent in sequence to cause a reduction reaction with artemisinin; S3. adjusting the pH of the reaction system obtained in step S2 to 5-7 with acid solution, adding water and stirring, separating the liquids, extracting the aqueous phase obtained by the separation with the same aprotic solvent as in step S1, combining the organic phase obtained by extraction and separation, washing with water, and drying, obtaining dried organic phase; S4. placing the dried organic phase obtained in step S3 in a crystallization device that has the functions of crystallization-press filtration-drying, and then the crystals are precipitated, concentrated, press-filtered, and dried to obtain the refined dihydroartemisinin.Type: GrantFiled: February 20, 2020Date of Patent: September 17, 2024Assignee: Vinsce Bio-pharm (Suzhou) Co., Ltd.Inventors: Xuedong Peng, Mei Zhang, Jinzhao Zhao, Yongyi Yan
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Publication number: 20240277923Abstract: An ambulatory pump having a disposable drug container comprised of a flexible IV-type bag sealed to a length of tubing extending from the IV bag. The IV bag is contained in a lightweight rigid housing facilitating attachment to the skin and providing a guide channel for the IV tube against a retaining wall. This allows a motorized backpack to be simply installed on the rigid housing of the drug container for peristaltic pumping of the medicine through the IV tube during use, and then removed from the drug container for reuse with a different drug container, minimizing the overall system cost.Type: ApplicationFiled: February 16, 2024Publication date: August 22, 2024Inventors: Chao Young Lee, Zhenhua Mao, James Zhimin Yan, Mei Zhang
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Patent number: 12045235Abstract: In a computer-implemented method for improving performance of a database optimizer, a processor calculates a first execution time for a database query executing through a first access path of a database system. A processor generates a second access path. A processor determines a second execution time via a simulation of the database query through the second access path. A processor determines that the second execution time is less than the first execution time. A processor, responsive to determining that the second execution time is less than the first execution time, sends the second access path to the database optimizer.Type: GrantFiled: December 14, 2020Date of Patent: July 23, 2024Assignee: International Business Machines CorporationInventors: Shuo Li, Xiaobo Wang, Sheng Yan Sun, Hong Mei Zhang
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Patent number: 12039299Abstract: In an embodiment, a computer-implemented method comprises identifying a theme of a process based on a set of communication information. The set of communication information is generated corresponding to performing the process. The method further comprises determining a plurality of roles in the process at least partly based on the set of communication information. The plurality of roles performs respective actions during performing the process. The method further comprises generating a framework of the process based on the theme and the plurality of roles. The framework comprises one or more branches. In other embodiments, a system and a computer program product are disclosed.Type: GrantFiled: November 12, 2020Date of Patent: July 16, 2024Assignee: International Business Machines CorporationInventors: Shuo Li, Xiaobo Wang, Hong Mei Zhang, Sheng Yan Sun
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Patent number: 12021181Abstract: The disclosed technology relates to a battery utilizing an indicator to orient an unopposed portion of a cathode or anode with respect to a battery can, and a tag to generate an electromagnetic field to mitigate or eliminate an electromagnetic field generated by the unopposed portion of the cathode or anode. The battery includes a wound set of layers including a cathode, an anode, and a separator; a can housing the wound set of layers; a lid disposed atop of the can to enclose the wound set of layers within the can; and a tag coupled to the lid. An unopposed portion of the cathode or anode generates a first electromagnetic field. The tag generates a second electromagnetic field to oppose the first electromagnetic field.Type: GrantFiled: September 11, 2020Date of Patent: June 25, 2024Assignee: Apple Inc.Inventors: Katherine I. Pregler, Kyle Tse, Samantha K. Young, Jason W. Brinsfield, Mei Zhang, Charles Greenlee, Kevin R. Richardson, Susheel Teja Gogineni, Ethan L. Huwe, Connor R. Duke, Michael B. Nussbaum, Shawn G. Fink, Kirill Kalinichev
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Publication number: 20240201394Abstract: Techniques for providing evacuation guidance parameters to a vehicle traversing in a geographical region in the presence of interfering GNSS signals are disclosed. In some embodiments, a vehicle can determine evacuation guidance parameters from characteristics of at least one interfering source and implement evasive maneuvers based on the evacuation guidance parameters. Alternatively, a vehicle can send characteristics of at least one interfering source to a central processing system located remotely from the vehicle, and receive evacuation guidance parameters from the central processing system.Type: ApplicationFiled: December 19, 2022Publication date: June 20, 2024Applicant: Honeywell International Inc.Inventors: Guoqing Wang, Karl Abraham Keyzer, Xiaoqiang Chen, Danhua Liang, Mei Zhang
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Publication number: 20240194515Abstract: A wafer handling device is configured to transport a wafer tray. The wafer handling device includes a sucker module and a transporting apparatus. The sucker module includes a sucker body, at least one airtight assembly, and a pump. The sucker body includes a first portion and a second portion. The first portion has a hole and a first air sucking hole. The second portion has a second air sucking hole. The airtight assembly is connected to the hole. The pump has a suction tube connected to the first air sucking hole and the second air sucking hole. The transporting apparatus is configured to move the sucker body. When the sucker body is connected to the wafer tray, the first portion, the second portion, and the wafer tray form an airtight space.Type: ApplicationFiled: March 13, 2023Publication date: June 13, 2024Inventors: Shun-Chi YEH, Fu-Hua YAN, Ze-Shan YAN, Xiao-Mei ZHANG
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Patent number: 12003406Abstract: A method, network device, and computer program product for network traffic diversion are disclosed. In one embodiment, a method according to the present disclosure includes receiving a frame at a core edge node that is a member of a redundancy group (where the frame comprises network address information and a packet), and determining whether a link is affected by a network failure. The frame was sourced by a remote core edge node that is not a member of the redundancy group, and the network address information indicates that the packet is to be forwarded via the link. In response to the link being affected by the network failure, the method further includes generating a modified frame and forwarding the modified frame to another core edge node. The generating comprises including a redirect label in the modified frame. The another core edge node is another member of the redundancy group.Type: GrantFiled: March 21, 2022Date of Patent: June 4, 2024Assignee: CISCO TECHNOLOGY, INC.Inventors: Patrice Brissette, Luc Andre Burdet, Jiri Chaloupka, Mei Zhang, Tarek Saad
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Patent number: 11970529Abstract: The present invention relates to an epitope on fibronectin B (ED-B) domain, more specifically to an antibody or an antibody fragment of ED-B domain, and can be widely applied in in-vitro detection and in-vivo positioning of ED-B domain as well as in targeted cancer therapy.Type: GrantFiled: November 5, 2021Date of Patent: April 30, 2024Assignee: Hefei Lifeon Pharmaceutical Co., Ltd.Inventors: Mei Zhang, Junqiu Ji, Meihua Gao, Jun Chen
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Patent number: 11960114Abstract: A backlight module and a display device are disclosed. The backlight module includes a back plate, an assembled light plate composed of multiple light plates, and a pressure bar. The assembled light plate is fixed to the back plate by the pressure bar. The pressure bar includes a fixing portion and a connecting portion. One end of the connecting portion goes through the gap, and the other end is connected to the fixing portion. The fixing portion extends from the gap to the light plates on both sides to form a first abutting portion and a second abutting portion. The surfaces of the first and the second abutting portions adjacent to the light plates are level and flush with each other. The first and the second abutting portions respectively abut and firmly press the light-emitting surfaces of the light plates on both sides. The fixed portion covers the entire gap.Type: GrantFiled: December 26, 2022Date of Patent: April 16, 2024Assignees: CHUZHOU HKC OPTOELECTRONICS TECHNOLOGY CO., LTD., HKC CORPORATION LIMITEDInventors: Mei Zhang, Haoxuan Zheng