Abstract: Disclosed are a smart head mount device and a housing thereof. The housing comprises a weight-reducing frame by at least a part of the housing The weight-reducing frame is made of at least an organic aerogel material and has a density of 0.4 g/cm3 to 1.3 g/cm3 and a bending modulus greater than 2.5 GPa.

Abstract: Described are antisense oligonucleotides comprising one or more ?-L-threofuranosyl (TNA) nucleosides linked to an adjacent nucleoside via a phosphodiester (PO) internucleoside linkage, as well as methods to modulate the properties of antisense oligonucleotides by the introduction of such TNA nucleosides. These are particularly applicable to antisense gapmer oligonucleotides.

Abstract: The present invention relates to antisense oligonucleotides which are complementary to conserved TDP-43 binding sites on pre-mRNA transcripts, which are capable of restoring RNA binding protein function in the processing of multiple independent mRNAs in TDP-43 depleted cells.

Abstract: Disclosed in the present disclosure are a dome and a diaphragm assembly for a sound producing apparatus, a sound producing apparatus, and an electronic device. The dome comprises an organic aerogel matrix and a reinforcing material dispersed in the organic aerogel matrix. The mass of the organic aerogel matrix accounts for 10% to 95% of the total mass of the dome, and the modulus density ratio of the dome is greater than or equal to 5 GPa·cm3/g. According to the present disclosure, the dome has a light weight, and thus facilitates meeting the design requirements of lightening, thinning and miniaturization of the sound producing apparatus, and can also reduce the resonance frequency of the sound producing apparatus and improve the medium-frequency sensitivity thereof.

Abstract: A housing of a sound generating device, the sound generating device and an electronic apparatus are provided. At least a part of the housing of the sound generating device is formed as a supporting part, at least a part of the supporting part is made of organic aerogel material, the organic aerogel material has a mesh structure on which reinforcement material is distributed, the reinforcement material accounts for 0 wt % to 40 wt % of the supporting part, and a specific modulus of the supporting part is 1.5 GPa·cm3/g to 40 GPa·cm3/g. At least part of the housing of the sound generating device is formed as the supporting part, the supporting part including organic aerogel material with a mesh structure and reinforcement material disposed on the mesh structure. Thus, the housing of the sound generating device has advantages of high strength, light weight and strong applicability.

Abstract: A housing of a sound production device, a sound production device, and an electronic apparatus. At least a part of the housing is a first support housing, and the first support housing includes a metal frame and an organic aerogel material, wherein the metal frame is a porous framework with a pore channel structure, and the organic aerogel material is distributed on a surface of the metal frame and in the pore channel structure.

Abstract: The present invention relates to antisense oligonucleotides which are complementary to conserved TDP-43 binding sites on pre-mRNA transcripts, which are capable of restoring RNA binding protein function in the processing of multiple independent mRNAs in TDP-43 depleted cells. The contiguous nucleotide sequence of the antisense oligonucleotides comprise 2?-O-methoxyethyl-RNA (2?-MOE) nucleosides and the antisense oligonucleotides are attached to cholesterol moieties.

Abstract: The present invention relates to double stranded oligonucleotides that are complementary to JAK1, leading to modulation of the expression of JAK1. Modulation of JAK1 expression is beneficial for a range of medical disorders including inflammatory bowel disease, organ transplant rejection, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis (RA), juvenile idiopathic arthritis, psoriasis, dermatitis, diabetic nephropathy, systemic lupus erythematosus (SLE), dry eye disease, cancer, myelofibrosis, and asthma. Also included are compositions comprising the double stranded oligonucleotide and methods of treatment using the double stranded oligonucleotide.

Abstract: A wireless secure communication method based on RIS-NOMA under complex channel conditions, the method including: firstly, an intelligent surface is assume to be disposed between the base station and legitimate NOMA users, and between the base station and eavesdroppers; the signal to interference plus distortion noise ratio (SIDNR) for the legitimate NOMA user and the eavesdropper is calculated in the presence of RHI in the system; secondly, considering shadow fading and to simplify the overly complex calculation process, the probability density function and cumulative distribution function of the shadow fading are approximated; finally, the outrage probability and intercept probability of the legitimate users and eavesdroppers are calculated.

Abstract: The present invention relates to a gapmer oligonucleotide comprising at least one phosphorodithioate internucleoside linkage of formula (I) as defined in the description and in the claims. The oligonucleotide of the invention can be used as a medicement.

Abstract: Described are antisense oligonucleotides comprising one or more ?-L-threofuranosyl (TNA) nucleosides as well as methods to modulate the properties of antisense oligonucleotides by the introduction of TNA nucleosides. These are particularly applicable for antisense gapmer oligonucleotides.

Abstract: The present invention relates to antisense oligonucleotides which are complementary to conserved TDP-43 binding sites on pre-mRNA transcripts, which are capable of restoring RNA binding protein function in the processing of multiple independent mRNAs in TDP-43 depleted cells.

Abstract: The present invention relates to antisense oligonucleotides which are complementary to conserved TDP-43 binding sites on pre-mRNA transcripts, which are capable of restoring RNA binding protein function in the processing of multiple independent mRNAs in TDP-43 depleted cells.

Abstract: The present invention relates to a compound of formula (II) or (IIb) Wherein X, Y, Rx, Ry, R5 and Nu are as defined in the description and in the claims. The compound of formula (II) can be used in the manufacture of oligonucleotides.

Abstract: The present invention relates to an oligonucleotide comprising at least one phosphorodithioate internucleoside linkage of formula (I) (I) as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicement.

Abstract: The present invention relates to antisense oligonucleotides which are complementary to conserved TDP-43 binding sites on pre-mRNA transcripts, which are capable of restoring RNA binding protein function in the processing of multiple independent mRNAs in TDP-43 depleted cells.

Abstract: The present invention relates to an oligonucleotide comprising at least one phosphorotrithioa to internucleoside linkage of formula (I), wherein (A1), (A2) and R are as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicament.

Abstract: The present invention relates to an oligonucleotide comprising at least one phosphorotrithioate internucleoside linkage of formula (I) as defined herein. The oligonucleotide of the invention can be used as a medicament.

Abstract: The present invention relates to a compound of formula (II) or (IIb) Wherein X, Y, Rx, Ry, R5 and Nu are as defined in the description and in the claims. The compound of formula (II) can be used in the manufacture of oligonucleotides.

Abstract: A method may add whey to high calcium papermaking industrial wastewater blended and pre-acidification treatment to promote anaerobic reaction and inhibit calcification. The method includes, before anaerobic treatment of papermaking wastewater, mixing whey wastewater with the papermaking wastewater. The method also includes pre-treating the papermaking wastewater by acidification to stabilize the papermaking wastewater prior to entering an anaerobic reaction system.