Abstract: A multi-analyte sensor system is provided, comprising: a transmitter for containing a battery the transmitter being for placement on top of patient skin; and an implantable multianalyte monolithic integrated circuit for placement beneath the patient skin, wherein the implantable multianalyte monolithic integrated circuit comprises a sensor control circuit (e.g., Potentiostat, Voltametric Circuit) and an electrochemical sensing element, wherein the electrochemical sensing element is configured to sense concentrations of two or more analytes and generate an electrical signal representative of these concentrations, and wherein sensor control circuit is electrically connected to the electrochemical sensing element and enables independent control of detection method and conditions (e.g., redox potential) at the integrated sensing circuit.

Abstract: Systems and methods are related to a successive approximation analog to digital converter (SAR ADC). The SAR ADC includes a sample and digital to analog conversion (DAC) circuit configured to sample an input voltage, a comparator circuit coupled to the sample and DAC circuit and having an output, a first set of storage circuits, and a comparator driver. The comparator driver is disposed between the output and the first set of storage circuits (e.g., ratioed latched. The first set of storage circuits are coupled to the comparator circuit and the sample and DAC circuit. The comparator driver can include a first driver and second driver. The first driver is coupled to a first input of a first storage circuit of the first set of storage circuits, and the second driver is coupled to first inputs of a second set of storage circuits within the first set of storage circuits.

Abstract: Systems and methods are related to a successive approximation analog to digital converter (SAR ADC). The SAR ADC includes a sample and digital to analog conversion (DAC) circuit configured to sample an input voltage, a comparator circuit coupled to the sample and DAC circuit and having an output, a first set of storage circuits, and a comparator driver. The comparator driver is disposed between the output and the first set of storage circuits (e.g., ratioed latched. The first set of storage circuits are coupled to the comparator circuit and the sample and DAC circuit. The comparator driver can include a first driver and second driver. The first driver is coupled to a first input of a first storage circuit of the first set of storage circuits, and the second driver is coupled to first inputs of a second set of storage circuits within the first set of storage circuits.

Abstract: There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (I) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Abstract: There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (I) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Abstract: There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (1) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Abstract: There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (1) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Abstract: Systems and methods are related to a successive approximation analog to digital converter (SAR ADC). The SAR ADC includes a sample and digital to analog conversion (DAC) circuit configured to sample an input voltage, a comparator circuit coupled to the sample and DAC circuit and having an output, a first set of storage circuits, and a comparator driver. The comparator driver is disposed between the output and the first set of storage circuits (e.g., ratioed latched. The first set of storage circuits are coupled to the comparator circuit and the sample and DAC circuit. The comparator driver can include a first driver and second driver. The first driver is coupled to a first input of a first storage circuit of the first set of storage circuits, and the second driver is coupled to first inputs of a second set of storage circuits within the first set of storage circuits.

Abstract: Systems and methods are related to a successive approximation analog to digital converter (SAR ADC). In one aspect, a method includes sampling, by a sample and digital to analog conversion (DAC) circuit, an input voltage to obtain a sampled voltage. The method also includes determining, by a comparator coupled to a set of storage circuits, a state of a plurality of bits corresponding to the sampled voltage. The comparator has a current parameter or voltage parameter adjusted based upon a conversion margin. Adjustment of the current parameter or the voltage parameter affects speed of determining the state of the bits. The method also includes storing the bits in the set of storage circuits. In some aspects, an SAR ADC is configured to perform the method.

Abstract: There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (I) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

Abstract: Monitoring of one or more key indicators can provide powerful insights into operation and state of different physical systems. For example, continuous monitoring of multiple analyte in body will allow for detailed insights into personal health and will allow for preventative health management. In this application, we present an ultra-small scale wireless sensing platform capable of long-term wireless in-vivo sensing. The key for extreme miniaturization lies in ultra-low-power compact design and lithographic integration of key system components. The key to low cost is using standard technologies and scalable manufacturing. For example, using standard semiconductor technologies for sensing, processing and wireless operation paves way to a low-cost integrated wireless sensing technology. Modern semiconductor technologies provide the capability to provide low-power and yet powerful electronics functionality in a small (mm-scale) size and wireless operation at high frequency.

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

Abstract: Monitoring of one or more key indicators can provide powerful insights into the operation and state of different physical systems. For example, continuous monitoring of multiple analytes in a subject allows for detailed insights into personal health as well as allowing for the implementation of preventative health measures. Herein are described design and processing methods for a small wireless multi-analyte sensing platform that can be used to monitor multiple analytes such as glucose, lactate, Urea and other physicochemical quantities. The design techniques and processing methods presented herein can be used for a multitude of other applications and are not limited to those described here.

Abstract: A sensor incorporates one or more working electrodes, a counter electrode and a reference electrode. The sensor is inserted in a needle and connected to control electronics to detect the concentration of target molecules. The electrodes are arrays of nanostructures increasing the detection surface area. The nanostructures are functionalized with nucleic acids which bind to select target molecules.

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

Abstract: A time-interleaved clock circuit, including circuitry to provide multiple clock components of a sampling clock. The clock components are corrected by averaging pairs of the multiple clock components in order to output averaged signals. The time-interleaved clock is applied to data conversion in which input signals of the analog signal domain or of the digital signal domain are sampled based on the corrected clock components and converted to the digital signal domain or the analog signal domain, respectively.

Abstract: A time-interleaved clock circuit, including circuitry to provide multiple clock components of a sampling clock. The clock components are corrected by averaging pairs of the multiple clock components in order to output averaged signals. The time-interleaved clock is applied to data conversion in which input signals of the analog signal domain or of the digital signal domain are sampled based on the corrected clock components and converted to the digital signal domain or the analog signal domain, respectively.

Abstract: A sensor incorporates one or more working electrodes, a counter electrode and a reference electrode. The sensor is inserted in a needle and connected to control electronics to detect the concentration of target molecules. The electrodes are arrays of nanostructures increasing the detection surface area. The nanostructures are functionalized with nucleic acids which bind to select target molecules.