Patents by Inventor Mel Silvers

Mel Silvers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060222351
    Abstract: An improved pre-heating, contiguous in-line water heater is described. The in-line water heater utilizes a passive heating means to passively heat at least a portion of the input water received by the in-line water heater. The result is a more cost efficient water heater. The in-line water heater is integrated with a means for control to receive input from at least one sensor and to regulate the operation of the in-line water heater.
    Type: Application
    Filed: February 12, 2004
    Publication date: October 5, 2006
    Inventors: Cem Cezayirli, Mel Silvers, Chester Gates
  • Patent number: 6977073
    Abstract: A method is described whereby dendritic cells derived from the CD34+ and CD 34?hematopoietic cell lineages are directed to become programmable antigen presenting cells. The programmed cells may be pulsed with tumor cell RNA or tumor cell RNA expression products. The protocol provides for directing the maturation of dendritic cells to become antigen presenting cells. The protocol further provides for isolating tumor cell RNA from biopsy material that has been prepared in paraffin block storage. The directed dendritic cell is provided with a plurality of tumor markers by using tumor RNA in toto, the poly A+RNA fraction or the expression product of such RNA. Once activated the dendritic cells are incubated with T4 and T8 lymphocytes to stimulate and sensitize the T lymphocytes which upon introduction either into a donor host or a nondonor recipient will provide immune response protection.
    Type: Grant
    Filed: November 10, 2003
    Date of Patent: December 20, 2005
    Inventors: Cem Cezayirli, Mel Silvers
  • Patent number: 6701069
    Abstract: An improved pre-heating, contiguous in-line water heater is described. The in-line water heater utilizes a passive heating means to passively heat at least a portion of the input water received by the in-line water heater. The result is a more cost efficient water heater. The in-line water heater is integrated with a control means to receive input from various sensor and to regulate the operation of the in-line water heater.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: March 2, 2004
    Inventors: Cem Cezayirli, Mel Silvers, Chester Z. Gates
  • Patent number: 6645487
    Abstract: A method is described whereby dendritic cells derived from the CD34+ and CD 34-hematopoietic cell lineages are directed to become programmable antigen presenting cells. The programmed cells may be pulsed with tumor cell RNA or tumor cell RNA expression products. The protocol provides for directing the maturation of dendritic cells to become antigen presenting cells. The protocol further provides for isolating tumor cell RNA from biopsy material that has been prepared in paraffin block storage. The directed dendritic cell is provided with a plurality of tumor markers by using tumor RNA in toto, the poly A+RNA fraction or the expression product of such RNA. Once activated the dendritic cells are incubated with T4 and T8 lymphocytes to stimulate and sensitize the T lymphocytes which upon introduction either into a donor host or a nondonor recipient will provide immune response protection.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: November 11, 2003
    Inventors: Cem Cezayirli, Mel Silvers
  • Patent number: 6586243
    Abstract: A method is described whereby dendritic cells derived from the CD34+ and CD 34− hematopoietic cell lineages are directed to become programmable antigen presenting cells. The programmed cells may be pulsed with tumor cell RNA or tumor cell RNA expression products. The protocol provides for directing the maturation of dendritic cells to become antigen presenting cells. The protocol further provides for isolating tumor cell RNA from biopsy material that has been prepared in paraffin block storage. The directed dendritic cell is provided with a plurality of tumor markers by using tumor RNA in toto, the poly A+RNA fraction or the expression product of such RNA. Once activated the dendritic cells are incubated with T4 and T8 lymphocytes to stimulate and sensitize the T lymphocytes which upon introduction either into a donor host or a nondonor recipient will provide immune response protection.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: July 1, 2003
    Inventors: Cem Cezayirli, Mel Silvers
  • Publication number: 20010005506
    Abstract: A method is described whereby dendritic cells derived from the CD34+ and CD 34− hematopoietic cell lineages are directed to become programmable antigen presenting cells. The programmed cells may be pulsed with tumor cell RNA or tumor cell RNA expression products. The protocol provides for directing the maturation of dendritic cells to become antigen presenting cells. The protocol further provides for isolating tumor cell RNA from biopsy material that has been prepared in paraffin block storage. The directed dendritic cell is provided with a plurality of tumor markers by using tumor RNA in toto, the poly A+RNA fraction or the expression product of such RNA. Once activated the dendritic cells are incubated with T4 and T8 lymphocytes to stimulate and sensitize the T lymphocytes which upon introduction either into a donor host or a nondonor recipient will provide immune response protection.
    Type: Application
    Filed: December 20, 2000
    Publication date: June 28, 2001
    Inventors: Cem Cezayirli, Mel Silvers
  • Patent number: 6251665
    Abstract: A method is described whereby dendritic cells derived from the CD34+ and CD34− hematopoietic cell lineages are directed to become programmable antigen presenting cells. The programmed cells may be pulsed with tumor cell RNA or tumor cell RNA expression products. The protocol provides for directing the maturation of dendritic cells to become antigen presenting cells. The protocol further provides for isolating tumor cell RNA from biopsy material that has been prepared in paraffin block storage. The directed dendritic cell is provided with a plurality of tumor markers by using tumor RNA in toto, the poly A+RNA fraction or the expression product of such RNA. Once activated the dendritic cells are incubated with T4 and T8 lymphocytes to stimulate and sensitize the T lymphocytes which upon introduction either into a donor host or a nondonor recipient will provide immune response protection.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: June 26, 2001
    Inventors: Cem Cezayirli, Mel Silvers
  • Publication number: 20010001066
    Abstract: A method is described whereby dendritic cells derived from the CD34+ and CD 34-hematopoietic cell lineages are directed to become programmable antigen presenting cells. The programmed cells may be pulsed with tumor cell RNA or tumor cell RNA expression products. The protocol provides for directing the maturation of dendritic cells to become antigen presenting cells. The protocol further provides for isolating tumor cell RNA from biopsy material that has been prepared in paraffin block storage. The directed dendritic cell is provided with a plurality of tumor markers by using tumor RNA in toto, the poly A+RNA fraction or the expression product of such RNA. Once activated the dendritic cells are incubated with T4 and T8 lymphocytes to stimulate and sensitize the T lymphocytes which upon introduction either into a donor host or a nondonor recipient will provide immune response protection.
    Type: Application
    Filed: December 20, 2000
    Publication date: May 10, 2001
    Inventors: Cem Cezayirli, Mel Silvers
  • Patent number: 6228640
    Abstract: A method is described whereby a dendritic cell derived from the CD34 hematopoietic cell lineage is directed to become a super antigen presenting cell that has been pulsed with tumor cell RNA or RNA expression products. The protocol provides for programming the maturation of dendritic cells to become antigen presenting cells. The protocol further provides for isolating tumor cell RNA from biopsy material that has been prepared in pariffin block storage. The directed dendritic cell is provided with a plurality of tumor markers by using tumor RNA in toto or the poly A+RNA fraction. Once activated the dendritic cells are incubated with T4 and T8 lymphocytes to stimulate and sensitize the T lymphocytes which upon introduction either into a donor host or a nondonor recipient will provide immune response protection.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: May 8, 2001
    Inventors: Cem Cezayirli, Mel Silvers