Abstract: The present invention provides an UNC5H2 splice variant polypeptide, UNC5H2d, and the nucleic acid molecule encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing the UNC5H2d polypeptide. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with the UNC5H2d polypeptide.

Abstract: This invention relates to a new family of secreted proteins, termed the SECFAM3 family, its family members including the novel human proteins INSP123, INSP124, and INSP125, herein identified as secreted proteins containing a von Willebrand Factor type C (vWFC) domain, and to the use to these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.

Abstract: This invention relates to the novel protein, termed INSP161, herein identified as a secreted protein, in particular, as a c1q domain containing protein and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.

Abstract: This invention relates to novel protein INSP058, herein identified as TNF-like secreted protein, and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention, and treatment of disease.

Abstract: This invention relates to the novel protein, termed INSP (179), herein identified as a secreted protein, in particular as a member of the leucine rich repeat containing protein family and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease.

Abstract: This invention relates to the novel protein, termed INSP163, herein identified as a secreted protein containing a jelly-roll fold, in particular, as a member of the TNF (tumor necrosis factor)-like family of cytokines, specifically as a C1q-like protein and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.

Abstract: The invention is based on the discovery that INSP100 is a splice variant of human chorionic somatomammotropin hormone 2 (HCS-B; Q14407) and that INSP104 is a splice variant of human chorionic somatomammotropin hormone 1 (hCS-A;P01243). The invention relates to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease. This invention relates to novel proteins, termed INSP100 and INSP104, herein identified as novel splice variants of human Chorionic somatomammotropin hormone 2 (hCS-B; Q14407) and human Chorionic somatomammotropin hormone 1 (hCS-A; P01243) respectively and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease. The variants have an altered A-B loop and are therefore predicted to possess altered receptor binding properties. All publications, patents and patent applications cited herein are incorporated in full by reference.

Abstract: This invention relates to a new family of secreted proteins, termed the SECFAMI family, its family members including the novel proteins INSP113, INSP114, INSP115, INSP116 and INSP117, herein identified as secreted proteins containing epidermal growth factor (EGF) fold-containing domains, ranging from 125-153 amino acids in length and containing eight conserved cysteine residues and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

Abstract: This invention relates to a novel protein, termed INSP101, herein identified as a novel splice variant of human pituitary growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.

Abstract: This invention relates to proteins, termed INSP093, herein identified as secreted proteins, in particular, as members of the Interleukin (IL) 8-like chemokine family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

Abstract: The invention is based on the discovery that the INSP106 protein is a novel splice variant of a known midkine family member (swall|P21741|MK_HUMAN).

Abstract: The present invention relates to novel proteins, termed INSP081, INSP082, and INSP091, herein identified as members of the Germinal Center Kinase (GCK) subfamily of the STE20 family of protein kinases, preferably as NCK-interacting kinases (NIKs) and more preferably as NIK-like embryo specific kinases (NESKs), and to the use of these and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.

Abstract: This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

Abstract: The invention is based on the discovery that the INSP017 protein functions as a trans-membrane protein molecule, preferably as a trans-membrane protein molecule of the netrin receptor family.