Patents by Inventor Melvin I. Simon

Melvin I. Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pain signaling molecules
    Patent number: 8916355
    Abstract: The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: December 23, 2014
    Assignee: California Institute of Technology
    Inventors: David J. Anderson, Xinzhong Dong, Mark Zylka, Sang-kyou Han, Melvin I. Simon
  • Method and device for regulating fluid flow in microfluidic devices
    Patent number: 8206975
    Abstract: A method and a microfluidic device are provided to regulate fluid flow by equalization of channel pressures. The fluid flow is regulated by way of valve-actuated channel pressures.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: June 26, 2012
    Assignee: California Institute of Technology
    Inventors: Xiaoyan Robert Bao, Stephen R. Quake, Melvin I. Simon
  • Assay employing G protein-coupled receptor expressed in dorsal root ganglia
    Patent number: 7510845
    Abstract: The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: March 31, 2009
    Assignee: California Institute of Technology
    Inventors: David J. Anderson, Xinzhong Dong, Mark J. Zylka, Sang-Kyou Han, Melvin I. Simon
  • Transgenic mouse comprising a disruption in an RGS9 gene
    Patent number: 6750375
    Abstract: The invention relates to an animal model for studying behavior related to RGS9 and RGS9 modulated dopamine D2-mediated behavior. The invention provides transgenic non-human animals in which RGS9 expression is disrupted, methods of using such animals, and methods of modulating dopamine D2-mediated behavior.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: June 15, 2004
    Assignee: California Institute of Technology
    Inventors: Johannes Schwarz, Ching-Kang Chen, Melvin I. Simon, Henry Lester
  • Pain signaling molecules
    Publication number: 20030092035
    Abstract: The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
    Type: Application
    Filed: June 26, 2002
    Publication date: May 15, 2003
    Inventors: David J. Anderson, Xinzhong Dong, Mark Zylka, Sang-Kyou Han, Melvin I. Simon
  • Methods of use of regulators of G-protein signaling to modulate dopamine signaling and dopamine-related neurobehavior
    Publication number: 20020095693
    Abstract: The invention relates to an animal model for studying behavior related to RGS9 and RGS9 modulated dopamine D2-mediated behavior. The invention provides transgenic non-human animals in which RGS9 expression is disrupted, methods of using such animals, and methods of modulating dopamine D2-mediated behavior.
    Type: Application
    Filed: October 23, 2001
    Publication date: July 18, 2002
    Inventors: Johannes Schwarz, Ching-Kang Chen, Melvin I. Simon, Henry Lester
  • Osmosensing histidine kinases
    Patent number: 5939306
    Abstract: The present invention relates to histidine kinases, including osmosensing fungal histidine kinases. In particular, the present invention provides amino acid and nucleic acid sequences of fungal histidine kinases from organisms such as Candida (e.g., C. albicans) and Neurospora (e.g., N. crassa). The present invention further provides compositions and methods for the development of antifungal compounds.
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: August 17, 1999
    Assignees: University Technology Corporation, California Institute of Technology
    Inventors: Lisa A. Alex, Melvin I. Simon, Claude Selitrennikoff, Jacqueline Agnan