Patents by Inventor Meng Cui
Meng Cui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240067683Abstract: The present disclosure relates to the field of biomedicine, in particular to the use of MCM8-cGAS-STING-IFN-I signal pathway as a disease target, including the use in the preparation of an animal model of a disease or the preparation of a product for the diagnosis, prevention, or treatment of a disease. In particular, the present disclosure comprises the use of a reagent for quantitatively detecting the gene expression or protein expression or protein activity of MCM8 in the preparation of a product for the diagnosis of a disease caused by dysfunctional mitophagy or caused by abnormal activation of cGAS-STING-IFN-I signaling pathway.Type: ApplicationFiled: August 20, 2021Publication date: February 29, 2024Inventors: Yuxia Zhang, Meng Lin, Huifang Xian, Zhanghua Chen, Fan Bai, Jun Cui, Xiaoqiong Gu
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Publication number: 20240069321Abstract: An apparatus for large-scale dynamic imaging of a sample is described. The apparatus includes an optical detector, a light guide, a dichroic beam splitter, and a light source. The light guide includes a first portion and a second portion. The second defines a tapered shape such that a first diameter defined by a distal end of the second portion is smaller than a second diameter defined by a proximal end of the second portion. The dichroic beam splitter is positioned between the first portion and the second portion of the light guide. The light source is configured to direct a light beam through an external surface of the dichroic beam splitter. The dichroic beam splitter is configured to direct the light beam toward the second open end of the light guide and transfer the return emitted signal through the light guide to the optical detector.Type: ApplicationFiled: August 30, 2023Publication date: February 29, 2024Applicant: Purdue Research FoundationInventor: Meng Cui
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Patent number: 11815456Abstract: Systems and methods for analyzing samples, such as tissue samples, and measuring the emissions when these samples are exposed to light are disclosed. Embodiments include illuminating multiple target locations on a sample with laser light, which may first be manipulated by a scanner, and receiving decaying emissions from the target location. At least some embodiments include the emissions traveling backwards along a substantial portion of the laser light pathway and being received by a detector. Additional embodiments include converting the received emissions into streak lines of position versus time, converting the streak lines to plots of signal strength versus time, and curve fitting the plots to determine representative decay times. In some embodiments, the decay times are presented as plots of position on the surface of the sample versus emission strength, which may be color coded. Some embodiment dwell on each target location for multiple scans of the laser.Type: GrantFiled: August 25, 2021Date of Patent: November 14, 2023Assignee: PURDUE RESEARCH FOUNDATIONInventor: Meng Cui
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Publication number: 20230333368Abstract: An optical system includes first and second optical scanners and first and second gradient-index (GRIN) lenses. The first optical scanner is configured to scan a laser beam in a first scanning path and output a first scanned beam. The first GRIN lens is configured to translate the first scanned beam therethrough. The second optical scanner is configured to scan the first scanned beam in a second scanning path and output as second scanned beam. The second scanning path has a scanning trajectory rotated by 90 degrees relative to the first scanning path. The second GRIN lens is configured to translate the second scanned beam therethrough and collect the emitted signal from the imaging target.Type: ApplicationFiled: January 19, 2023Publication date: October 19, 2023Inventor: Meng Cui
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Publication number: 20230273417Abstract: A confocal microscope system includes a light source configured to form a light beam, a scanning unit, and an objective lens. The scanning unit is in the form of a mechanically driven scanning unit with a controllable scanning trajectory, and is configured to direct the light beam through the scanning trajectory. The objective lens defines a pupil plane and a focal plane. The light beam is directed from the scanning unit to the objective lens. The confocal microscope system is configured for multi-color line-scanning confocal microscopy, and implements multi-color fluorescence imaging without laser excitation crosstalk.Type: ApplicationFiled: August 11, 2022Publication date: August 31, 2023Inventors: Meng Cui, Hehai Jiang
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Publication number: 20230266577Abstract: High speed laser scanning systems and methods are disclosed for imaging target samples. Embodiments of the laser scanning systems and methods include separating a laser beam into two or more different pathways and pulsing light along the two or more pathways. The different pathways intersect the surface of a moving mirror at different locations and light traveling in a pathway that is being approached by an edge of the moving reflective surface is turned off while light traveling in a different pathway that is farther from the edge of the moving reflective surface is turned on. Embodiments include reflective surfaces that form a rotating polygonal scanner. Further embodiments include recombining the two or more different pathways, focusing the laser light on a test sample, and imaging the light reflected from the test sample.Type: ApplicationFiled: February 21, 2023Publication date: August 24, 2023Inventor: Meng CUI
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Publication number: 20230236092Abstract: Apparatuses for cutting tissue include an oscillator assembly and a clamp. The oscillator assembly defines a resonance frequency and includes a frame, an excitation element, and a blade. The frame has an upper portion and a lower portion, and the lower portion is configured to oscillate relative to the upper portion. The excitation element is coupled with the lower portion of the frame, and the excitation element is selectively operable to provide an excitation signal to the oscillator assembly sufficient to cause the oscillator assembly to oscillate at the resonance frequency. The blade is coupled with the lower portion for sectioning tissue. The clamp is selectively moveable along the frame to alter the resonance frequency of the oscillator assembly.Type: ApplicationFiled: September 30, 2022Publication date: July 27, 2023Inventor: Meng Cui
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Publication number: 20230159500Abstract: A compound according to Formula (I) or a pharmaceutically acceptable salt thereof: is provided. X1 is N or C-Y; Y is H, halogen, NH2, OH, SH, alkyl, aryl, alkoxy, or aryloxy; A is O, NH, S, Se, or CH2, B is X2 is N or CH; and Z is NH, CH2, S, O, or Se.Type: ApplicationFiled: September 29, 2022Publication date: May 25, 2023Inventors: Miao Zhang, Keykavous Parang, Naglaa Ibrahim, Young Woo Nam, Ilya Bezprozvanny, Meng Cui
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Patent number: 11599994Abstract: An optical tissue imaging system includes a probe for insertion into a transparent cylindrical capillary. The capillary includes an internal cylindrical channel that extends along a central axis. The capillary is inserted into tissue of a subject, and the probe may rotate and translate within the capillary. The probe may include a mirror configured to reflect light to the tissue outside of the cylindrical capillary.Type: GrantFiled: March 28, 2020Date of Patent: March 7, 2023Assignee: Purdue Research FoundationInventor: Meng Cui
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Publication number: 20230024345Abstract: A data processing method and apparatus, a device, and a non-transitory computer-readable storage medium are provided. A target data table is obtained that includes at least two index keywords corresponding to a target object. Metadata information corresponding to the target data table is merged to obtain a metadata management table. Feature mapping is performed on data in the target data table according to the metadata management table in order to obtain data features corresponding to the at least two index keywords in the target data table and in order to generate data feature tables. The data feature tables are merged to obtain an index table. A metadata management table is constructed through the metadata information of the target data table. An index table corresponding to the target data table is generated according to the metadata management table to implement the inverted index of the data through the index table.Type: ApplicationFiled: September 26, 2022Publication date: January 26, 2023Applicant: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITEDInventors: Hongjia CHEN, Lingying ZENG, Jixuan CAI, Meng CUI, Wuxiong ZENG
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Publication number: 20220065783Abstract: Systems and methods for analyzing samples, such as tissue samples, and measuring the emissions when these samples are exposed to light are disclosed. Embodiments include illuminating multiple target locations on a sample with laser light, which may first be manipulated by a scanner, and receiving decaying emissions from the target location. At least some embodiments include the emissions traveling backwards along a substantial portion of the laser light pathway and being received by a detector. Additional embodiments include converting the received emissions into streak lines of position versus time, converting the streak lines to plots of signal strength versus time, and curve fitting the plots to determine representative decay times. In some embodiments, the decay times are presented as plots of position on the surface of the sample versus emission strength, which may be color coded. Some embodiment dwell on each target location for multiple scans of the laser.Type: ApplicationFiled: August 25, 2021Publication date: March 3, 2022Applicant: Purdue Research FoundationInventor: Meng Cui
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Publication number: 20210301643Abstract: A method for evaluating a downhole working condition of a PDC bit includes: performing an indoor test, including performing a drilling test in different full-sized cores by using the PDC bit with different degrees of abrasion and balling under condition of given WOB and rotational speed, to acquire change characteristics of a WOB, a rotational speed, a torque, a ROP and a bit vibration of the PDC bit in different time domains; improving and perfecting an existing prediction model and evaluation method for the downhole working condition through data obtained by the test to obtain the method; reading parameters of the WOB, the rotational speed, the torque and the ROP in real time during drilling; determining the downhole working condition of the PDC bit by using the method in the improving and perfecting.Type: ApplicationFiled: March 16, 2021Publication date: September 30, 2021Inventors: Guodong JI, Haige WANG, Meng CUI, Zhao MENG, Qiang WU, Li LIU, Jiawei ZHANG, Changchang CHEN, Liu CUI, Jing YU
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Publication number: 20200311930Abstract: An optical tissue imaging system includes a probe for insertion into a transparent cylindrical capillary. The capillary includes an internal cylindrical channel that extends along a central axis. The capillary is inserted into tissue of a subject, and the probe may rotate and translate within the capillary. The probe may include a mirror configured to reflect light to the tissue outside of the cylindrical capillary.Type: ApplicationFiled: March 28, 2020Publication date: October 1, 2020Applicant: Purdue Research FoundationInventor: Meng Cui
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Patent number: 9780122Abstract: An array substrate, a display panel and a display device are provided. The array substrate includes: a substrate, wherein a signal transmission line, a first insulator layer, a second insulator layer, a pixel electrode layer and a common electrode layer are disposed on the substrate, wherein the first insulator layer is disposed between the signal transmission line and the common electrode layer, and the second insulator layer is disposed between the pixel electrode layer and the common electrode layer, and wherein a dielectric constant of the first insulator layer is less than or equal to a dielectric constant of the second insulator layer, and the signal transmission line is electrically connected with the common electrode layer. A parasitic capacitance between the signal transmission line and the common electrode layer is reduced in the array substrate.Type: GrantFiled: September 23, 2015Date of Patent: October 3, 2017Assignees: SHANGHAI TIANMA MICRO-ELECTRONICS CO., LTD., TIANMA MICRO-ELECTRONICS CO., LTD.Inventors: Yong Yuan, Quanpeng Yu, Meng Cui, Zhongshou Huang
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Patent number: 9720218Abstract: A system for a laser-scanning microscope includes an optical element configured to transmit light in a first direction onto a first beam path and to reflect light in a second direction to a second beam path that is different from the first beam path; a reflector on the first beam path; and a lens including a variable focal length, the lens positioned on the first beam path. The lens and reflector are positioned relative to each other to cause light transmitted by the optical element to pass through the lens a plurality of times and in a different direction each time. In some implementations, the system also can include a feedback system that receives a signal that represents an amount of focusing of the lens, and changes the focal length of the lens based on the received signal.Type: GrantFiled: August 5, 2014Date of Patent: August 1, 2017Assignee: Howard Hughes Medical InstituteInventors: Meng Cui, Lingjie Kong
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Publication number: 20160293632Abstract: An array substrate, a display panel and a display device are provided. The array substrate includes: a substrate, wherein a signal transmission line, a first insulator layer, a second insulator layer, a pixel electrode layer and a common electrode layer are disposed on the substrate, wherein the first insulator layer is disposed between the signal transmission line and the common electrode layer, and the second insulator layer is disposed between the pixel electrode layer and the common electrode layer, and wherein a dielectric constant of the first insulator layer is less than or equal to a dielectric constant of the second insulator layer, and the signal transmission line is electrically connected with the common electrode layer. A parasitic capacitance between the signal transmission line and the common electrode layer is reduced in the array substrate.Type: ApplicationFiled: September 23, 2015Publication date: October 6, 2016Inventors: Yong Yuan, Quanpeng Yu, Meng Cui, Zhongshou Huang
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Publication number: 20150042992Abstract: A system for a laser-scanning microscope includes an optical element configured to transmit light in a first direction onto a first beam path and to reflect light in a second direction to a second beam path that is different from the first beam path; a reflector on the first beam path; and a lens including a variable focal length, the lens positioned on the first beam path. The lens and reflector are positioned relative to each other to cause light transmitted by the optical element to pass through the lens a plurality of times and in a different direction each time. In some implementations, the system also can include a feedback system that receives a signal that represents an amount of focusing of the lens, and changes the focal length of the lens based on the received signal.Type: ApplicationFiled: August 5, 2014Publication date: February 12, 2015Inventors: Meng Cui, Lingjie Kong
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Patent number: 8866107Abstract: Wavefront distortions of an optical beam are measured. The transverse optical modes of the optical beam are partitioned into a plurality of subsets of transverse optical modes, one of the subsets of transverse optical modes is selected as the current subset, and the optical beam is modulated based on the current subset by maintaining the transverse optical modes of the optical beam that are outside the current subset stable, and modulating the transverse optical modes of the optical beam within the current subset. A non-linear optical signal is generated from the modulated optical beam by directing the modulated optical beam through a non-linear optical system that includes a random scattering medium, the power of the generated non-linear optical signal is measured, and, based on the measured power, values of the spatial phase for the optical beam at transverse optical modes are extracted within the current subset.Type: GrantFiled: July 12, 2012Date of Patent: October 21, 2014Assignee: Howard Hughes Medical InstituteInventor: Meng Cui
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Patent number: 8830573Abstract: A 4-Pi microscope for imaging a sample, comprising a first objective for focusing a first light beam on the sample at a spatial point one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include a sensor for detecting the first light beam that has been transmitted through the sample and inputted on the sensor; and a spatial light modulator (SLM) for outputting, in response to the first light beam detected by the sensor, a second light beam that is an optical phase conjugate of the first light beam; and a second objective positioned to transmit the first light beam to the sensor and focus the second light beam on the sample at the spatial point, so that the first light beam and the second light beam are counter-propagating and both focused to the spatial point.Type: GrantFiled: November 10, 2010Date of Patent: September 9, 2014Assignee: California Institute of TechnologyInventors: Meng Cui, Changhuei Yang
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Patent number: 8760661Abstract: An apparatus includes a spatial light modulator configured to receive an optical pulse train; and output a modulated optical pulse train; a non-linear optical system that receives the modulated optical pulse train and generates a non-linear optical signal; and a power detector that detects a power of the generated non-linear optical signal. A control system outputs a signal to the spatial light modulator to cause it to modulate the optical pulse train by modulating the spectral phase of the optical pulse at wavelengths within a current wavelength range subset and maintain the spectral phase of the optical pulse constant at wavelengths outside the current wavelength range subset; and based on the detected power, extracts values of the spectral phase for the optical pulse at wavelengths within the current wavelength range subset, the values extracted being those that compress the optical pulses.Type: GrantFiled: May 3, 2012Date of Patent: June 24, 2014Assignee: Howard Hughes Medical InstituteInventor: Meng Cui