Patents by Inventor Meng Cui
Meng Cui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8830573Abstract: A 4-Pi microscope for imaging a sample, comprising a first objective for focusing a first light beam on the sample at a spatial point one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include a sensor for detecting the first light beam that has been transmitted through the sample and inputted on the sensor; and a spatial light modulator (SLM) for outputting, in response to the first light beam detected by the sensor, a second light beam that is an optical phase conjugate of the first light beam; and a second objective positioned to transmit the first light beam to the sensor and focus the second light beam on the sample at the spatial point, so that the first light beam and the second light beam are counter-propagating and both focused to the spatial point.Type: GrantFiled: November 10, 2010Date of Patent: September 9, 2014Assignee: California Institute of TechnologyInventors: Meng Cui, Changhuei Yang
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Patent number: 8760661Abstract: An apparatus includes a spatial light modulator configured to receive an optical pulse train; and output a modulated optical pulse train; a non-linear optical system that receives the modulated optical pulse train and generates a non-linear optical signal; and a power detector that detects a power of the generated non-linear optical signal. A control system outputs a signal to the spatial light modulator to cause it to modulate the optical pulse train by modulating the spectral phase of the optical pulse at wavelengths within a current wavelength range subset and maintain the spectral phase of the optical pulse constant at wavelengths outside the current wavelength range subset; and based on the detected power, extracts values of the spectral phase for the optical pulse at wavelengths within the current wavelength range subset, the values extracted being those that compress the optical pulses.Type: GrantFiled: May 3, 2012Date of Patent: June 24, 2014Assignee: Howard Hughes Medical InstituteInventor: Meng Cui
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Patent number: 8717574Abstract: A detector of light transmitted through a turbid medium, comprising: one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include (1) a sensor for detecting input light that has been transmitted through the turbid medium and inputted on the sensor; and (2) a spatial light modulator (SLM) for outputting, in response to the input light detected by the sensor, output light that is an optical phase conjugate of the input light.Type: GrantFiled: November 10, 2010Date of Patent: May 6, 2014Assignee: California Institute of TechnologyInventors: Changhuei Yang, Meng Cui
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Patent number: 8716677Abstract: An apparatus includes a transverse scanning optical system in the path of a first light beam traveling along a first optic axis; a wavefront correction system in the path of a second light beam traveling along a second optic axis, the wavefront correction system including a wavefront correction device having a spatial phase profile on its surface; a beam combiner that receives the first light beam and the second light beam and outputs an interference beam having a beat frequency equal to a difference frequency between the first light beam and second light beam; and a detection system placed relative to a random scattering medium, which is in the path of the interference beam. The detection system detects measurement light produced by the random scattering medium while the interference beam strikes the random scattering medium.Type: GrantFiled: January 18, 2012Date of Patent: May 6, 2014Assignee: Howard Hughes Medical InstituteInventor: Meng Cui
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Publication number: 20130285892Abstract: A Liquid Crystal Display (LCD) panel includes a pixel array, a scanning line driver, a common electrode driver, and a data line driver. During a current frame, the scanning lines receive a scanning signal. The common electrode driver applies a common electrode signal to the common electrode line during a time window in which the scanning line corresponding to the common electrode line receives the scanning signal. The data line driver applies a data signal to the data lines during a time window in which the scanning line driver outputs the scanning signal. The data signals of adjacent pixel rows have opposite polarities, the common electrode signal during the current frame is opposite to the common electrode signal during a next frame, and the data signals of the pixel row in the current frame have opposite polarities of the data signals applied on the pixel row during the next frame.Type: ApplicationFiled: June 25, 2013Publication date: October 31, 2013Inventors: Dong QIAN, Hanyu GU, Chang-ho TSENG, Meng CUI
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Publication number: 20130182253Abstract: Wavefront distortions of an optical beam are measured. The transverse optical modes of the optical beam are partitioned into a plurality of subsets of transverse optical modes, one of the subsets of transverse optical modes is selected as the current subset, and the optical beam is modulated based on the current subset by maintaining the transverse optical modes of the optical beam that are outside the current subset stable, and modulating the transverse optical modes of the optical beam within the current subset. A non-linear optical signal is generated from the modulated optical beam by directing the modulated optical beam through a non-linear optical system that includes a random scattering medium, the power of the generated non-linear optical signal is measured, and, based on the measured power, values of the spatial phase for the optical beam at transverse optical modes are extracted within the current subset.Type: ApplicationFiled: July 12, 2012Publication date: July 18, 2013Applicant: Howard Hughes Medical InstituteInventor: Meng Cui
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Patent number: 8450674Abstract: A light microscope for imaging a sample containing one or more fluorescent agents, comprising a source for generating acoustic waves that are focused at a focus in the sample, wherein the acoustic waves frequency shift a frequency of light passing through the focus, thereby creating a frequency shifted light beam; at least one spatial light modulator (SLM) positioned to illuminate the sample with an output beam that is an optical phase conjugate of the frequency shifted light beam, wherein the output beam is a reflection of a first reference beam off one or more pixels of the SLM, and the pixels are for modulating the first reference beam to create the output beam; and a detector positioned to detect fluorescence generated by the output beam exciting the fluorescent agents at the focus in the sample, thereby imaging the sample.Type: GrantFiled: November 10, 2010Date of Patent: May 28, 2013Assignees: California Institute of Technology, Northeastern UniversityInventors: Changhuei Yang, Charles DiMarzio, Meng Cui, Ying Min Wang
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Publication number: 20130114630Abstract: An apparatus includes a spatial light modulator configured to receive an optical pulse train; and output a modulated optical pulse train; a non-linear optical system that receives the modulated optical pulse train and generates a non-linear optical signal; and a power detector that detects a power of the generated non-linear optical signal. A control system outputs a signal to the spatial light modulator to cause it to modulate the optical pulse train by modulating the spectral phase of the optical pulse at wavelengths within a current wavelength range subset and maintain the spectral phase of the optical pulse constant at wavelengths outside the current wavelength range subset; and based on the detected power, extracts values of the spectral phase for the optical pulse at wavelengths within the current wavelength range subset, the values extracted being those that compress the optical pulses.Type: ApplicationFiled: May 3, 2012Publication date: May 9, 2013Applicant: HOWARD HUGHES MEDICAL INSTITUTEInventor: Meng Cui
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Publication number: 20130015367Abstract: An apparatus includes a transverse scanning optical system in the path of a first light beam traveling along a first optic axis; a wavefront correction system in the path of a second light beam traveling along a second optic axis, the wavefront correction system including a wavefront correction device having a spatial phase profile on its surface; a beam combiner that receives the first light beam and the second light beam and outputs an interference beam having a beat frequency equal to a difference frequency between the first light beam and second light beam; and a detection system placed relative to a random scattering medium, which is in the path of the interference beam. The detection system detects measurement light produced by the random scattering medium while the interference beam strikes the random scattering medium.Type: ApplicationFiled: January 18, 2012Publication date: January 17, 2013Applicant: Howard Hughes Medical InstituteInventor: Meng Cui
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Publication number: 20110309267Abstract: A method, apparatus, and article of manufacture for irradiating a sample with electromagnetic (EM) radiation. A number of passes of EM radiation through a sample are formed and/or selected, wherein the EM radiation in each of the passes comprises (1) input EM radiation incident on the sample, and (2) transmitted EM radiation exiting the sample formed from the input EM radiation that is transmitted through the sample. A phase conjugate of the transmitted EM radiation is used as the input EM radiation in a next pass of the EM radiation. The number of passes results in one or more EM fields of the input EM radiation having at least a threshold transmittance through the sample.Type: ApplicationFiled: June 9, 2011Publication date: December 22, 2011Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Meng Cui, Changhuei Yang
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Publication number: 20110122416Abstract: A detector of light transmitted through a turbid medium, comprising: one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include (1) a sensor for detecting input light that has been transmitted through the turbid medium and inputted on the sensor; and (2) a spatial light modulator (SLM) for outputting, in response to the input light detected by the sensor, output light that is an optical phase conjugate of the input light.Type: ApplicationFiled: November 10, 2010Publication date: May 26, 2011Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Changhuei Yang, Meng Cui
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Publication number: 20110108707Abstract: A light microscope for imaging a sample containing one or more fluorescent agents, comprising a source for generating acoustic waves that are focused at a focus in the sample, wherein the acoustic waves frequency shift a frequency of light passing through the focus, thereby creating a frequency shifted light beam; at least one spatial light modulator (SLM) positioned to illuminate the sample with an output beam that is an optical phase conjugate of the frequency shifted light beam, wherein the output beam is a reflection of a first reference beam off one or more pixels of the SLM, and the pixels are for modulating the first reference beam to create the output beam; and a detector positioned to detect fluorescence generated by the output beam exciting the fluorescent agents at the focus in the sample, thereby imaging the sample.Type: ApplicationFiled: November 10, 2010Publication date: May 12, 2011Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Meng Cui, Ying Min Wang, Charles DiMarzio, Changhuei Yang
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Publication number: 20110109962Abstract: A 4-Pi microscope for imaging a sample, comprising a first objective for focusing a first light beam on the sample at a spatial point one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include a sensor for detecting the first light beam that has been transmitted through the sample and inputted on the sensor; and a spatial light modulator (SLM) for outputting, in response to the first light beam detected by the sensor, a second light beam that is an optical phase conjugate of the first light beam; and a second objective positioned to transmit the first light beam to the sensor and focus the second light beam on the sample at the spatial point, so that the first light beam and the second light beam are counter-propagating and both focused to the spatial point.Type: ApplicationFiled: November 10, 2010Publication date: May 12, 2011Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Meng Cui, Changhuei Yang
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Publication number: 20040203094Abstract: A method and composition for tRNA synthetases that activate and aminoacylate nonstandard and noncognate amino acids to tRNA adaptor molecules is described that can be used to generate custom designed protein products for uses in medicinal, therapeutic, diagnostic, biotechnology, engineering, and spectroscopy applications. Some tRNA synthetases naturally misactivate and misaminoacylate noncognate amino acids. Many of these tRNA synthetases, including but not limited to leucyl-, isoleucyl-, and valyl-tRNA synthetases, have evolved proofreading and editing mechanisms to correct these mistakes. Inactivation of the enzyme's editing activity allows and facilitates production and accumulation of tRNAs that are misaminoacylated with nonstandard and noncognate amino acids. These misaminoacylated tRNAs can be used to introduce novel amino acids into proteins.Type: ApplicationFiled: September 20, 2002Publication date: October 14, 2004Inventors: Susan A. Martinis, James M. Briggs, Richard S. Mursinna, Keun Woo Lee, Tommie L. Lincecum, Caleb Davis, Meng Cui, Amy M. Williams, Joshua A. Speidel, Yuxin Zhai