Patents by Inventor Merl F. Hoekstra

Merl F. Hoekstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Abasic site endonuclease assay
    Patent number: 7790385
    Abstract: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: September 7, 2010
    Assignee: Elitech Holding B.V.
    Inventors: Igor V. Kutyavin, David Milesi, Merl F. Hoekstra
  • Molecular modification assays
    Patent number: 7745142
    Abstract: Assays for detecting molecular modifications such as phosphate modifications and the presence and/or activity of enzymes and other agents involved in facilitating or otherwise regulating such modifications.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: June 29, 2010
    Assignee: Molecular Devices Corporation
    Inventors: Annegret Boge, Luke D. Lavis, J. Richard Sportsman, Merl F. Hoekstra, Wei Huang
  • Method for amplifying target nucleic acid sequences using a primer comprising an AP endonuclease-cleavable linker
    Patent number: 7553643
    Abstract: The present invention provides a novel method for nucleic acid amplification. The method includes contacting the sample with at least one forward primer and at least one reverse primer, an AP endonuclease, and a nucleic acid polymerase. under conditions sufficient to allow the forward and reverse primers to hybridize to the target nucleic acid and form a reaction mixture, wherein at least one of the forward and reverse primer includes an AP endonuclease-cleavable linker L, and incubating the reaction mixture under reaction conditions that simultaneously allow the AP endonuclease to cleave at a linker site L and the extension of the primers in a template-specific manner to amplify the target nucleic acid sequence.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: June 30, 2009
    Assignee: EPoch Biosciences, Inc.
    Inventors: Igor V. Kutyavin, David Milesi, Merl F. Hoekstra
  • ABASIC SITE ENDONUCLEASE ASSAY
    Publication number: 20080166782
    Abstract: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.
    Type: Application
    Filed: June 28, 2007
    Publication date: July 10, 2008
    Applicant: Epoch Biosciences, Inc.
    Inventors: Igor V. Kutyavin, David Milesi, Merl F. Hoekstra
  • Methods for modulating signal transduction mediated by TGF-? and related proteins
    Patent number: 7358056
    Abstract: Methods are provided for identifying agents that modulate signaling mediated by transforming growth factor beta (TGF-?) and members of the TGF-? family, such as bone morphogenic protein (BMP). Such agents may be identified using screens that evaluate candidate agents for the ability to modulate Smad protein degradation. Agents identified as described herein may be used to augment or inhibit signaling mediated by one or more TGF-? family members in a variety of cell types and for therapeutic purposes.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: April 15, 2008
    Assignee: Signal Pharmaceuticals
    Inventors: Merl F. Hoekstra, Weilin Xie, Brion W. Murray, Frank M. Mercurio
  • Abasic site endonuclease assay
    Patent number: 7252940
    Abstract: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: August 7, 2007
    Assignee: Epoch Biosciences, Inc.
    Inventors: Igor V. Kutyavin, David Milesi, Merl F. Hoekstra
  • Molecular modification assays
    Patent number: 7070921
    Abstract: Assays for detecting molecular modifications such as phosphate modifications and the presence and/or activity of enzymes and other agents involved in facilitating or otherwise regulating such modifications.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: July 4, 2006
    Assignee: Molecular Devices Corporation
    Inventors: Wei Huang, Merl F. Hoekstra, J. Richard Sportsman, Ewald A. Terpetschnig
  • Molecular modification assays
    Publication number: 20040249586
    Abstract: Assays for detecting molecular modifications such as phosphate modifications and the presence and/or activity of enzymes and other agents involved in facilitating or otherwise regulating such modifications.
    Type: Application
    Filed: December 23, 2003
    Publication date: December 9, 2004
    Inventors: Annegret Boge, Luke D. Lavis, J. Richard Sportsman, Merl F. Hoekstra, Wei Huang
  • Abasic site endonuclease assay
    Publication number: 20040101893
    Abstract: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.
    Type: Application
    Filed: August 20, 2003
    Publication date: May 27, 2004
    Applicant: Epoch Biosciences, Inc.
    Inventors: Igor V. Kutyavin, David Milesi, Merl F. Hoekstra
  • Methods for modulating signal transduction mediated by TGF-beta related proteins
    Publication number: 20030119072
    Abstract: Methods are provided for identifying agents that modulate signaling mediated by transforming growth factor beta (TGF-&bgr;) and members of the TGF-&bgr; family, such as bone morphogenic protein (BMP). Such agents may be identified using screens that evaluate candidate agents for the ability to modulate Smad protein degradation. Agents identified as described herein may be used to augment or inhibit signaling mediated by one or more TGF-&bgr; family members in a variety of cell types and for therapeutic purposes.
    Type: Application
    Filed: December 2, 2002
    Publication date: June 26, 2003
    Applicant: Signal Pharmaceuticals, Inc.
    Inventors: Merl F. Hoekstra, Weilin Xie, Brion W. Murray, Frank M. Mercurio
  • Materials and methods for modulating differentiation
    Publication number: 20020142976
    Abstract: This invention generally relates to materials and methods for modulating the differentiation of cells. Specifically provided are methods to promote or inhibit cell differentiation and methods to identify compounds that promote cellular differentiation.
    Type: Application
    Filed: March 27, 2001
    Publication date: October 3, 2002
    Applicant: ICOS Corporation
    Inventors: Merl F. Hoekstra, Mathew J. Thayer
  • Molecular modification assays
    Publication number: 20020034766
    Abstract: Assays for detecting molecular modifications such as phosphate modifications and the presence and/or activity of enzymes and other agents involved in facilitating or otherwise regulating such modifications.
    Type: Application
    Filed: April 27, 2001
    Publication date: March 21, 2002
    Inventors: Wei Huang, Merl F. Hoekstra, J. Richard Sportsman, Ewald A. Terpetschnig
  • Materials and methods for modulating differentiation
    Patent number: 6071691
    Abstract: This invention generally relates to materials and methods for modulating the differentiation of cells. Specifically provided are methods to promote or inhibit cell differentiation and methods to identify compounds that promote cellular differentiation.
    Type: Grant
    Filed: April 27, 1998
    Date of Patent: June 6, 2000
    Assignee: Oregon Health Science University
    Inventors: Merl F. Hoekstra, Mathew J. Thayer
  • Protein kinases
    Patent number: 6060296
    Abstract: Protein kinase mutant and wild-type genes encoding polypeptides of the class heretofore designated "casein kinase I" and useful in screening compositions which may affect DNA double-strand break repair activity are disclosed. Also disclosed are methods using the polynucleotides in cell-proliferative disorders.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: May 9, 2000
    Assignee: The Salk Institute for Biological Studies
    Inventor: Merl F. Hoekstra
  • Lipid kinase
    Patent number: 5985589
    Abstract: The present invention generally relates to a novel catalytic subunit of a lipid kinase designated p110.delta.. Polynucleotides encoding p110.delta. and recombinant p110.delta. polypeptides are provided along with antibodies to p110.delta., assays for identifying inhibitors of p110.delta., and the like.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: November 16, 1999
    Assignee: ICOS Corporation
    Inventors: David H. Chantry, Merl F. Hoekstra, Douglas A. Holtzman
  • Lipid kinase
    Patent number: 5882910
    Abstract: The present invention generally relates to a novel catalytic subunit of a lipid kinase designated p110.delta.. Polynucleotides encoding p110.delta. and recombinant p110.delta. polypeptides are provided along with antibodies to p110.delta., assays for identifying inhibitors of p110.delta., and the like.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: March 16, 1999
    Assignee: ICOS Corporation
    Inventors: David H. Chantry, Merl F. Hoekstra, Douglas A. Holtzman
  • Lipid kinase
    Patent number: 5858753
    Abstract: The present invention generally relates to a novel catalytic subunit of a lipid kinase designated p110.delta.. Polynucleotides encoding p110.delta. and recombinant p110.delta. polypeptides are provided along with antibodies to p110.delta., assays for identifying inhibitors of p110.delta., and the like.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: January 12, 1999
    Assignee: ICOS Corporation
    Inventors: David H. Chantry, Merl F. Hoekstra, Douglas A. Holtzman
  • Materials and methods relating to proteins that interact with casein kinase I
    Patent number: 5846764
    Abstract: The present invention relates generally to identification of proteins, designated TIH proteins, that interact with casein kinase I isoforms and to isolation of polynucleotides encoding the same.
    Type: Grant
    Filed: January 23, 1995
    Date of Patent: December 8, 1998
    Assignee: ICOS Corporation
    Inventors: Anthony J. DeMaggio, Merl F. Hoekstra
  • Protein kinases
    Patent number: 5756289
    Abstract: Protein kinase mutant and wild-type genes encoding polypeptides of the class heretofore designated "casein kinase I" and useful in screening compositions which may affect DNA double-strand break repair activity are disclosed. Also disclosed are methods using the polynucleotides in cell-proliferative disorders.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: May 26, 1998
    Assignee: Salk Institute for Biological Studies
    Inventor: Merl F. Hoekstra
  • TIH1, protein that interacts with casein kinase I
    Patent number: 5728806
    Abstract: The present invention relates generally to identification of proteins, designated TIH proteins, that interact with casein kinase I isoforms and to isolation of polynucleotides encoding the same.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 17, 1998
    Assignee: ICOS Corporation
    Inventors: Anthony J. DeMaggio, Merl F. Hoekstra