Abstract: The present invention relates to a sealing system, its uses and method of use for forming a seal against a surface, and in particular for plugging and sealing an orifice such as a road or railway tunnel to prevent or minimise the dispersion of hazardous agent(s) in an emergency scenario. The system comprises a frame (200) which can be orientated against a surface (50) of an orifice, frame (10) comprising a perimeter outer surface (180) through which pliant elements (40) can extrude, via apertures (22), following the initiation of a means (30) for providing an overpressure.

Abstract: The present invention relates to a sealing system, its uses and method of use for forming a seal against a surface, and in particular for plugging and sealing an orifice such as a road or railway tunnel to prevent or minimise the dispersion of hazardous agent(s) in an emergency scenario. The system comprises a frame (200) which can be orientated against a surface (50) of an orifice, frame (10) comprising a perimeter outer surface (180) through which pliant elements (40) can extrude, via apertures (22), following the initiation of a means (30) for providing an overpressure.

Abstract: An improved amphibious vehicle comprising: a drive train; a plurality of ground engaging wheels; a cooling system; a water propulsion system; and a hull which defines a passenger compartment, wherein the form/shape of the hull below the waterline is substantially defined by a plurality of buoyancy modules that are demountably mountable to the amphibious vehicle.

Abstract: An improved amphibious vehicle comprising: a drive train; a plurality of ground engaging wheels; a cooling system; a water propulsion system; and a hull which defines a passenger compartment, wherein the form/shape of the hull below the waterline is substantially defined by a plurality of buoyancy modules that are demountably mountable to the amphibious vehicle.

Abstract: An improved amphibious vehicle comprising: a drive train; a plurality of ground engaging wheels; a cooling system; a water propulsion system; and a hull which defines a passenger compartment, wherein the form/shape of the hull below the waterline is substantially defined by a plurality of buoyancy modules that are demountably mountable to the amphibious vehicle.

Abstract: A roller door system (100) particularly for opening and closing a doorway (120) defined in the wall of a lightweight structure (110) such as a marquee, hangar, field hospital, emergency shelter and the like. The door system comprises a rollable door (150) secured, in use, along one edge of the doorway (152); a roller (140) for rolling and unrolling the rollable door about the roller; an opening mechanism and a closing mechanism for controlling the deployment of the rollable door by translating the roller across the doorway; and reusable sealing means (135, 136, 155, 156) for sealing between the lateral margins of the rollable door and the doorway; characterized in that the rollable door comprises a plurality of collapsible hoses (165, 166) connected to a pressurized fluid power system (160, 161, 163) such that in use a positive pressure applied to the fluid power system causes the rollable door to unroll from the roller and controls the deployment of the rollable door.

Abstract: A roller door system (100) particularly for opening and closing a doorway (120) defined in the wall of a lightweight structure (110) such as a marquee, hangar, field hospital, emergency shelter and the like. The door system comprises a rollable door (150) secured, in use, along one edge of the doorway (152); a roller (140) for rolling and unrolling the rollable door about the roller; an opening mechanism and a closing mechanism for controlling the deployment of the rollable door by translating the roller across the doorway; and reusable sealing means (135, 136, 155, 156) for sealing between the lateral margins of the rollable door and the doorway; characterised in that the rollable door comprises a plurality of collapsible hoses (165, 166) connected to a pressurised fluid power system (160, 161, 163) such that in use a positive pressure applied to the fluid power system causes the rollable door to unroll from the roller and controls the deployment of the rollable door.

Abstract: The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.

Abstract: The present invention relates to novel benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.

Abstract: Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.

Abstract: The invention relates to compounds of formula (I): processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.

Abstract: Certain compounds of formula (I), or a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein R1, R2, P, P?, n, p, q, r and s are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds and composition in medicine.

Abstract: The invention relates to compounds of formula (I): processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.

Abstract: Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.

Abstract: The invention relates to compounds of formula (I): processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.

Abstract: Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.

Abstract: Disclosed are motilin agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract: The present invention relates to novel biaryl derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.

Abstract: Certain compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, P, P?, X, m and n are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds in medicine.

Abstract: Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.