Patents by Inventor Mervyn Thompson

Mervyn Thompson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PIPERAZINYL-SULFONAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES
    Publication number: 20100256364
    Abstract: Disclosed are motilin agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Application
    Filed: November 26, 2008
    Publication date: October 7, 2010
    Inventors: Darren Jason Mitchell, Jonathan Thomas Seal, Geoffrey Stemp, Mervyn Thompson, Susan Marie Westaway
  • Quinoline derivatives and their use as 5-HTligands
    Patent number: 7799774
    Abstract: Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: September 21, 2010
    Assignee: Glaxo Group Limited
    Inventors: Mahmood Ahmed, Christopher Norbert Johnson, Martin C Jones, Gregor James MacDonald, Stephen Frederick Moss, Mervyn Thompson, Charles Edward Wade, David R Witty
  • Gpr38 Receptor Agonists
    Patent number: 7700599
    Abstract: The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: April 20, 2010
    Assignee: Glaxo Group Limited
    Inventors: Mervyn Thompson, Susan Marie Westaway
  • QUINOLINE DERIVATIVES AND THEIR USE AS 5-HT6 LIGANDS
    Publication number: 20090298841
    Abstract: The present invention relates to novel quinoline compounds having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
    Type: Application
    Filed: August 14, 2009
    Publication date: December 3, 2009
    Inventors: Mahmood Ahmed, Christopher Norbert Johnson, Martin C. Jones, Gregor James MacDonald, Stephen Frederick Moss, Mervyn Thompson, Charles Edward Wade, David R. Witty
  • Quinoline derivatives and their use as 5-HT6 ligands
    Patent number: 7601837
    Abstract: The present invention relates to novel quinoline compounds having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: October 13, 2009
    Assignee: Glaxo Group Limited
    Inventors: Mahmood Ahmed, Christopher Norbert Johnson, Gregor James MacDonald, Stephen Frederick Moss, Mervyn Thompson, David R Witty
  • COMPOUNDS
    Publication number: 20090192160
    Abstract: The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.
    Type: Application
    Filed: April 2, 2009
    Publication date: July 30, 2009
    Inventors: Darren Jason MITCHELL, Jonathan Thomas Seal, Mervyn Thompson, Susan Marie Westway, Samantha Louisa Brown
  • Urea-compounds active as vanilloid receptor antagonists for the treatment of pain
    Publication number: 20090163506
    Abstract: Certain compounds of formula (I), or a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein R1, R2, P, P?, n, p, q, r and s are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds and composition in medicine.
    Type: Application
    Filed: September 13, 2002
    Publication date: June 25, 2009
    Applicant: SMITHKLINE BEECHAM PLC.
    Inventors: Harshad Kantilal Rami, Mervyn Thompson, Paul Adrian Wyman
  • Vanilloid receptor modulators
    Patent number: 7538121
    Abstract: Certain compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, P, X, Y, q, r ans s are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds in medicine.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: May 26, 2009
    Assignee: Glaxo Group Limited
    Inventors: Gregor James MacDonald, Darren Jason Mitchell, Harshad Kantilal Rami, Mervyn Thompson, Susan Marie Westaway
  • BENZYLPIPERAZINE DERIVATIVES AS MOTILIN RECEPTOR ANTAGONISTS
    Publication number: 20090131453
    Abstract: The invention relates to compounds of formula (I): processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.
    Type: Application
    Filed: June 14, 2007
    Publication date: May 21, 2009
    Inventors: Jonathan Thomas Seal, Geoffrey Stemp, Mervyn Thompson, Susan Marie Westaway
  • Carboxamide derivatives
    Patent number: 7531558
    Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein P, W, X, Y, R2, R3, r and s are as defined in the specification, processes for preparing such compounds, pharmaceutical compositions comprising such compounds and their use in therapy.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: May 12, 2009
    Assignee: Glaxo Group Limited
    Inventors: Gregor James Macdonald, Darren Jason Mitchell, Harshad Kantilal Rami, Mervyn Thompson, Leontine Saskia Trouw, Susan Marie Westaway
  • Urea derivatives having vanilloid receptor antagonist activity
    Patent number: 7528150
    Abstract: According to the invention there are provided compounds of formula (I) wherein R1, p, P, n, s, r, W, P?, t, R2 and q are as defined in the specification, processes for preparing them and their use in therapy.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: May 5, 2009
    Assignee: Glaxo Group Limited
    Inventors: Gregor James MacDonald, Harshad Kantilal Rami, Mervyn Thompson
  • Heterocyclic urea derivatives for the treatment of pain
    Patent number: 7528151
    Abstract: Compounds of formula (I): or a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein: P, P?, R1, R2, n, p, q, r, and s are as defined in the specification, processes for preparing such compounds, pharmaceutical compositions comprising such compounds and their use in therapy.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: May 5, 2009
    Assignee: Glaxo Group Limited
    Inventors: Stephen Frederick Moss, Harshad Kantilal Rami, Mervyn Thompson, David Richard Witty
  • Urea derivatives and their use as vanilloid receptor antagonists in the treatment of pain
    Patent number: 7514562
    Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein P, P?, W, R1, R2, n, p, q, r, s and t are as defined in the specification, processes for preparing such compounds, pharmaceutical compositions comprising such compounds and their use in therapy.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: April 7, 2009
    Assignee: Glaxo Group Limited
    Inventors: Stephen Christopher Martin Fell, Harshad Kantilal Rami, Mervyn Thompson, David Richard Witty
  • BENZYLPIPERAZINE DERIVATIVES AND THEIR MEDICAL USE
    Publication number: 20090054456
    Abstract: The present invention relates to novel benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.
    Type: Application
    Filed: July 24, 2006
    Publication date: February 26, 2009
    Inventors: Christopher Norbert Johnson, David Timothy Macpherson, Steven James Stanway, Geoffrey Stemp, Mervyn Thompson, Susan Marie Westaway
  • Quinoline Derivatives and Their Use as 5-HT6 Ligands
    Publication number: 20090036682
    Abstract: The present invention relates to novel quinoline compounds having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
    Type: Application
    Filed: September 5, 2008
    Publication date: February 5, 2009
    Inventors: Mahmood AHMED, Christopher Norbert Johnson, Martin C. Jones, Gregor James MacDonald, Stephen Frederick Moss, Mervyn Thompson, Charles Edward Wade, David R. Witty
  • Novel Compounds
    Publication number: 20090012099
    Abstract: Disclosed is a method for use of phenyl sulfone compounds of formula (I) in the treatment of Alzheimer's disease and age related cognitive decline.
    Type: Application
    Filed: September 11, 2008
    Publication date: January 8, 2009
    Inventors: Gregor James MacDonald, Mervyn Thompson
  • Piperazine Heteroaryl Derivatives as Gpr38 Agonists
    Publication number: 20080312209
    Abstract: The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Z, X and B are as defined in the specification. The compounds are partial or full agonists at the GPR38 receptor. Pharmaceutical compositions comprising the compounds, methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.
    Type: Application
    Filed: July 12, 2005
    Publication date: December 18, 2008
    Inventors: Gregor James MacDonald, Steven James Stanway, Mervyn Thompson, Susan Marie Westaway
  • Biaryl Compounds Useful as Agonists of the Gpr38 Receptor
    Publication number: 20080306083
    Abstract: The present invention relates to novel biaryl derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.
    Type: Application
    Filed: December 1, 2006
    Publication date: December 11, 2008
    Inventors: Gregor James MacDonald, Darren Jason Mitchell, Mervyn Thompson, Susan Marie Westaway
  • Quinoline derivatives and their use as 5-ht6 ligands
    Patent number: 7452888
    Abstract: Disclosed are novel quinoline compounds of formula (I), processes for their preparation, compositions containing them and their use in the treatment of CNS disorders.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: November 18, 2008
    Assignee: Glaxo Group Limited
    Inventors: Mahmood Ahmed, Christopher Norbert Johnson, Martin C Jones, Gregor James Macdonald, Stephen Frederick Moss, Mervyn Thompson, Charles Edward Wade, David R Witty
  • Compounds
    Patent number: 7439245
    Abstract: Disclosed is a method for use of phenyl sulfone compounds of formula (I) in the treatment of anxiety.
    Type: Grant
    Filed: May 13, 2008
    Date of Patent: October 21, 2008
    Assignee: Glaxo Group Limited
    Inventors: Gregor James MacDonald, Mervyn Thompson