Abstract: The present invention relates to a method for monitoring migration, invasion, and metastasis of cancer cells by observing the shape of cancer cells cultured in a three-dimensional environment and measuring the activity, expression, and changes in expression sites of proteins associated with invadopodia formation and metastasis, and the degradation of an extracellular matrix; and to a method for screening a cancer metastasis inhibitor. More specifically, it was verified that the reduction in c-Jun phosphorylation induced the increase in snail1 and the decrease in cortactin expression in the cells cultured in a three-dimensional environment and the expression regulation relations between the proteins were identical to those in breast cancer tissues obtained from patients.

Abstract: In one example embodiment, a genome ontology device may determine one or more super-concepts to be included in an ontology, generate a first genome database, from a genome, that includes at least one first title, at least one first field name and at least one first field value, select, from among the one or more super-concepts, one or more super-concepts that correspond to the first genome database, search web-based sources using at least one first key word associated with the one or more super-concepts and the first database, retrieve, from results of the search, a plurality of sub-concepts subsumed by the one or more super-concepts and one or more respective relationships between the one or more super-concepts and the plurality of sub-concepts, and generate the ontology based on the super-concepts, the retrieved sub-concepts, and the retrieved relationships.

Abstract: In one example embodiment, a server may divide documents into a plurality of morphological segments, parse, from the plurality of morphological segments, a plurality of named biological entities, tag the plurality of named biological entities and the plurality of morphological segments, generate a database that includes the tagged named biological entities and the tagged morphological segments, receive a first search term including one or more of the tagged named biological entities or one or more of the tagged morphological segments, search the database for at least one result phrase that includes at least one occurrence of the first search term, receive an input to retrieve a second search term including at least one morphological segment from one of the result phrases, store the second search term as a mining search term, and mine for the one or more documents based on the mining search term.

Abstract: This disclosure relates to an angiogenesis-related pharmaceutical composition using connective tissue growth factor, more particularly to a pharmaceutical composition for promoting angiogenesis containing the connective tissue growth factor or a pharmaceutical composition for inhibiting angiogenesis containing at least one selected from the group consisting of polypeptide, antibody and a compound binding to connective tissue growth factor.

Abstract: This disclosure relates to an angiogenesis-related pharmaceutical composition using connective tissue growth factor, more particularly to a pharmaceutical composition for promoting angiogenesis containing the connective tissue growth factor or a pharmaceutical composition for inhibiting angiogenesis containing at least one selected from the group consisting of polypeptide, antibody and a compound binding to connective tissue growth factor.