Abstract: Described herein are compounds or conjugates of Formula I or II and their pharmaceutically acceptable salts, solvates, or stereoisomers, as well as their uses (e.g., as VHL-binding agents or bifunctional degraders for degrading certain proteins (e.g., STAT3)).

Abstract: Described herein are compounds of Formula II and their pharmaceutically acceptable salts, solvates, or stereoisomers, as well as their uses (e.g., as SMARCA2 or SMARCA4 degraders).

Abstract: A robust on-orbit geometric calibration (GC) method based on the rational polynomial coefficient (RPC) model for spaceborne segmented linear-array camera is proposed. Through a series of processing steps, including obtaining reliable ground control point (GCP) observations based a priori gross error elimination, constructing the adjustment model for GC parameters, GC for absolute geometric distortion, GC for relative geometric distortions among segmented charge-coupled devices (CCDs), and the correction for the created bias field-of-view (FOV) distortion, this invention is able to achieve robust GC for camera distortion, as well as accurate geometric splicing and registration of segmented CCDs under the same geometric benchmark.

Abstract: This disclosure discloses a method and system of hue-distance constrained relative radiometric correction considering Helmholtz-Kohlrausch (H-K) effect for multiple remote sensing images. The method comprises: first converting the image from the RGB color space to the CIELAB color space, then performing relative radiometric correction using adaptive constraint based on hue-distance, and quantitatively describing the H-K effect to apply global lightness mapping to the corrected image. Based on the limitations of the RGB color space, this disclosure proposes a relative radiometric correction strategy that maintains hue distance, which suppresses radiometric anomalies in local regions and optimizes correction results. By implementing global lightness mapping based on the H-K effect and introducing perceived lightness into the relative radiometric correction of remote sensing images, this method effectively enhances the radiation consistency of multi-temporal images.

Abstract: Described herein are compounds or conjugates of Formula II and pharmaceutically acceptable salts, solvates, or stereoisomers thereof, as well as their uses (e.g., as cereblon-binding agents or bifunctional degraders for degrading certain proteins).

Abstract: The present disclosure provides compounds represented by Formula I: wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are EED inhibitors. EED inhibitors are useful for the treatment of cancer and other diseases.

Abstract: The present disclosure provides compounds represented by Formula I: wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are EED inhibitors. EED inhibitors are useful for the treatment of cancer and other diseases.

Abstract: Provided is a novel anti-CD3 humanized antibody. The anti-CD3 humanized antibody can specifically bind to human and monkey CD3 proteins, and said antibody has good biological activity.

Abstract: The present disclosure relates to compounds of Formula (I), and the pharmaceutically A—(CH2)m—X—Y—Z—B1??I, acceptable salts and solvates thereof, wherein A, m, X, Y, Z, and B1 are as defined as set forth in the specification. The present disclosure also relates to uses of the compounds, e.g., in treating or preventing a condition or disorder responsive to the degradation of CBP/P300 proteins (e.g., cancer).

Abstract: A robust on-orbit geometric calibration (GC) method based on the rational polynomial coefficient (RPC) model for spaceborne segmented linear-array camera is proposed. Through a series of processing steps, including obtaining reliable ground control point (GCP) observations based a priori gross error elimination, constructing the adjustment model for GC parameters, GC for absolute geometric distortion, GC for relative geometric distortions among segmented charge-coupled devices (CCDs), and the correction for the created bias field-of-view (FOV) distortion, this invention is able to achieve robust GC for camera distortion, as well as accurate geometric splicing and registration of segmented CCDs under the same geometric benchmark.

Abstract: Disclosed are a leaf vein flow channel bionic air-cooled fuel cell module supporting lung air intake, and a method thereof. A circular columnar stack is arranged in a cylindrical impeller and is placed in a cylindrical sealing volute, such that the circular columnar stack is suitable for the cylindrical body structure of drones and unmanned submersibles. A cathode surface and an anode surface are integrated on a same bipolar plate. The cathode surface adopts a mesh vein distribution pattern imitating veins of a lotus leaf, and the anode surface adopts a distribution pattern imitating veins of a banana leaf. In this way, even diffusion of gas is facilitated, and gas reaction is even. In addition, parasitic power consumed by a motor driving an impeller is small.

Abstract: Described herein are compounds of Formula I and pharmaceutically acceptable salts, solvates, or stereoisomers thereof, as well as their uses as STAT5 and/or STAT6 inhibitors.

Abstract: Described herein are compounds of Formula I and pharmaceutically acceptable salts, solvates, or stereoisomers thereof, as well as their uses as STAT5 and/or STAT6 degraders.

Abstract: The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein R1, R3, L, Y, and B1 are as defined in the specification. Compounds having Formula I are SHP2 protein degraders useful for the treatment of cancer and other diseases.

Abstract: A method of fully autonomous geometric calibration for linear-array remote sensing satellite (LARSS) based on the joint observation for stars and earth by satellite, with the support of satellite's high maneuverability is proposed. This invention realizes the full-link processing from data acquisition to internal and external calibration. Based on the ultra-high attitude stability and agile maneuverability, this invention designs a joint observation mode for the star and the earth, which is suitable for autonomous geometric calibration. With the joint observations, this invention achieves the external calibration through the star observations acquired in the solar shadow area, and achieves the internal calibration through the ground overlapping images acquired in the solar illumination area. Therefore, the high-precision geometric imaging model of the LARSS would be restored by the method, under the condition without using the ground calibration sites.

Abstract: Disclosed a passive wireless sensor for detecting discrete droplets and bubbles. A first inductor channel and a second inductor channel are disposed opposite each other to form a capacitor channel, the first inductor channel is connected to the second inductor channel to form a resonant circuit. When a detection object passes through the detection channel, the permittivity between the first inductor channel and the second inductor channel changes and consequently a capacitance value of the capacitor channel changes, thus resulting in a change in resonant frequency of the resonant circuit. A readout device is used to read the resonant frequency of the resonant circuit and perform detection according to the resonant frequency to obtain information of a corresponding detection object.

Abstract: The present disclosure provides compounds represented by Formula I: wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are EED inhibitors. EED inhibitors are useful for the treatment of cancer and other diseases.

Abstract: Disclosed a passive wireless sensor for detecting discrete droplets and bubbles. A first inductor channel and a second inductor channel are disposed opposite each other to form a capacitor channel, the first inductor channel is connected to the second inductor channel to form a resonant circuit. When a detection object passes through the detection channel, the permittivity between the first inductor channel and the second inductor channel changes and consequently a capacitance value of the capacitor channel changes, thus resulting in a change in resonant frequency of the resonant circuit. A readout device is used to read the resonant frequency of the resonant circuit and perform detection according to the resonant frequency to obtain information of a corresponding detection object.

Abstract: Disclosed is a passive wireless device for microfluidic detection of multi-level droplets. A primary inductor channel and a secondary inductor channel each comprise two layers of inductance coils, and the inductance coils of the primary inductor channel and the secondary inductor channel are alternately arranged in each layer. A double-resonance circuit is formed after a liquid conductive material is injected. A first part of a detection channel is disposed between a primary capacitor channel, and a second part of a detection channel is disposed between a secondary capacitor channel. A reading device is used to read a resonant frequency of the double-resonance circuit, and perform detection according to the resonant frequency to obtain information of a corresponding first droplet group and/or second droplet group.

Abstract: Disclosed is a passive wireless device for microfluidic detection of multi-level droplets. A primary inductor channel and a secondary inductor channel each comprise two layers of inductance coils, and the inductance coils of the primary inductor channel and the secondary inductor channel are alternately arranged in each layer. A double-resonance circuit is formed after a liquid conductive material is injected. A first part of a detection channel is disposed between a primary capacitor channel, and a second part of a detection channel is disposed between a secondary capacitor channel. A reading device is used to read a resonant frequency of the double-resonance circuit, and perform detection according to the resonant frequency to obtain information of a corresponding first droplet group and/or second droplet group.