Abstract: Described herein are compounds of Formula I and pharmaceutically acceptable salts, solvates, or stereoisomers thereof, as well as their uses as STAT5 and/or STAT6 degraders.

Abstract: The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein R1, R3, L, Y, and B1 are as defined in the specification. Compounds having Formula I are SHP2 protein degraders useful for the treatment of cancer and other diseases.

Abstract: A method of fully autonomous geometric calibration for linear-array remote sensing satellite (LARSS) based on the joint observation for stars and earth by satellite, with the support of satellite's high maneuverability is proposed. This invention realizes the full-link processing from data acquisition to internal and external calibration. Based on the ultra-high attitude stability and agile maneuverability, this invention designs a joint observation mode for the star and the earth, which is suitable for autonomous geometric calibration. With the joint observations, this invention achieves the external calibration through the star observations acquired in the solar shadow area, and achieves the internal calibration through the ground overlapping images acquired in the solar illumination area. Therefore, the high-precision geometric imaging model of the LARSS would be restored by the method, under the condition without using the ground calibration sites.

Abstract: Disclosed a passive wireless sensor for detecting discrete droplets and bubbles. A first inductor channel and a second inductor channel are disposed opposite each other to form a capacitor channel, the first inductor channel is connected to the second inductor channel to form a resonant circuit. When a detection object passes through the detection channel, the permittivity between the first inductor channel and the second inductor channel changes and consequently a capacitance value of the capacitor channel changes, thus resulting in a change in resonant frequency of the resonant circuit. A readout device is used to read the resonant frequency of the resonant circuit and perform detection according to the resonant frequency to obtain information of a corresponding detection object.

Abstract: The present disclosure provides compounds represented by Formula I: wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are EED inhibitors. EED inhibitors are useful for the treatment of cancer and other diseases.

Abstract: Disclosed a passive wireless sensor for detecting discrete droplets and bubbles. A first inductor channel and a second inductor channel are disposed opposite each other to form a capacitor channel, the first inductor channel is connected to the second inductor channel to form a resonant circuit. When a detection object passes through the detection channel, the permittivity between the first inductor channel and the second inductor channel changes and consequently a capacitance value of the capacitor channel changes, thus resulting in a change in resonant frequency of the resonant circuit. A readout device is used to read the resonant frequency of the resonant circuit and perform detection according to the resonant frequency to obtain information of a corresponding detection object.

Abstract: Disclosed is a passive wireless device for microfluidic detection of multi-level droplets. A primary inductor channel and a secondary inductor channel each comprise two layers of inductance coils, and the inductance coils of the primary inductor channel and the secondary inductor channel are alternately arranged in each layer. A double-resonance circuit is formed after a liquid conductive material is injected. A first part of a detection channel is disposed between a primary capacitor channel, and a second part of a detection channel is disposed between a secondary capacitor channel. A reading device is used to read a resonant frequency of the double-resonance circuit, and perform detection according to the resonant frequency to obtain information of a corresponding first droplet group and/or second droplet group.

Abstract: Disclosed is a passive wireless device for microfluidic detection of multi-level droplets. A primary inductor channel and a secondary inductor channel each comprise two layers of inductance coils, and the inductance coils of the primary inductor channel and the secondary inductor channel are alternately arranged in each layer. A double-resonance circuit is formed after a liquid conductive material is injected. A first part of a detection channel is disposed between a primary capacitor channel, and a second part of a detection channel is disposed between a secondary capacitor channel. A reading device is used to read a resonant frequency of the double-resonance circuit, and perform detection according to the resonant frequency to obtain information of a corresponding first droplet group and/or second droplet group.

Abstract: A method of jitter detection and image restoration for high-resolution TDI CCD satellite images. The method includes: obtaining a parallax image after a sub-pixel matching method relying on a correlation coefficient and least squares algorithm; transferring a jitter offset from an image space to an object space by an integral transformation function (ITF); dealing with a continuous push-broom mode of cameras in a discrete way with a denser sampling strategy according to a continue dynamic shooting model (CDSM), obtaining a specialized CDSM and feeding it back to the ITF; applying the accurate ITF to the obtained parallax image and conducting the jitter curve fitting to achieve the jitter detection; estimating a correspondent partial PSF according to the CDSM and the obtained jitter curve; carrying out an adaptive restoration based on context through optimal window Wiener filtering, by means of multiple input and single output to completes the image restoration.

Abstract: A method of jitter detection and image restoration for high-resolution TDI CCD satellite images. The method includes: obtaining a parallax image after a sub-pixel matching method relying on a correlation coefficient and least squares algorithm; transferring a jitter offset from an image space to an object space by an integral transformation function (ITF); dealing with a continuous push-broom mode of cameras in a discrete way with a denser sampling strategy according to a continue dynamic shooting model (CDSM), obtaining a specialized CDSM and feeding it back to the ITF; applying the accurate ITF to the obtained parallax image and conducting the jitter curve fitting to achieve the jitter detection; estimating a correspondent partial PSF according to the CDSM and the obtained jitter curve; carrying out an adaptive restoration based on context through optimal window Wiener filtering, by means of multiple input and single output to completes the image restoration.

Abstract: A liquid crystal on silicon, a wavelength selective switch, an alignment direction obtaining method, and a method for manufacturing a liquid crystal on silicon. The liquid crystal on silicon has a first pixel area, and a first liquid crystal located in the first pixel area. The first liquid crystal is deflected in a plane perpendicular to a first panel, and is deflected towards a first direction in a plane parallel to the first panel. An alignment direction of the first partial alignment film located in the first pixel area is deflected towards a second direction relative to a polarization direction of an incident beam, and the second direction is opposite to the first direction to reduce a loss of a deflected beam.

Abstract: A flow monitoring system is described for monitoring flow of a mixed-phase sample comprising at least a first phase and a second phase having different electrical conductivities, the second phase being a liquid or a gas and substantially electrically non-conductive and the first phase being a liquid and having a conductivity higher than the second phase.

Abstract: A liquid crystal on silicon, a wavelength selective switch, an alignment direction obtaining method, and a method for manufacturing a liquid crystal on silicon. The liquid crystal on silicon has a first pixel area, and a first liquid crystal located in the first pixel area. The first liquid crystal is deflected in a plane perpendicular to a first panel, and is deflected towards a first direction in a plane parallel to the first panel. An alignment direction of the first partial alignment film located in the first pixel area is deflected towards a second direction relative to a polarization direction of an incident beam, and the second direction is opposite to the first direction to reduce a loss of a deflected beam.

Abstract: A memory protection module includes comparison logic that has a write-once window CSR that stores a memory address range, and window protection logic. The comparison logic receives a memory write transaction, determines a memory address of the memory write transaction, and provides an indication as to whether or not the memory address is included in the memory address range. The window protection logic receives the memory transaction receives the indication from the comparison logic, allows the memory write transaction to proceed in response to the indication indicating that the memory address is not included in the memory address range, and drops the memory write transaction in response to the indication indicating that the memory address is included in the memory address range.

Abstract: Tomography apparatus comprises: a plurality of electrodes arranged around a perimeter of a cross section of a sample volume for containing a liquid or mixed-phase sample, each electrode being arranged to be in electrical contact with a sample contained in the sample volume; measurement means adapted to perform a set of measurements, each measurement comprising driving a current between a first respective adjacent pair of said electrodes and measuring a voltage developed across a second respective adjacent pair of said electrodes; and processing means adapted to generate a tomogram indicative of sample conductivity over said cross section from said set of measurements. The processing means is arranged to calculate sample conductivity values of a portion of said cross section from said set of measurements and generate said tomogram from said calculated sample conductivity values of said portion using an assumption of symmetry.

Abstract: A memory protection module includes comparison logic that has a write-once window CSR that stores a memory address range, and window protection logic. The comparison logic receives a memory write transaction, determines a memory address of the memory write transaction, and provides an indication as to whether or not the memory address is included in the memory address range. The window protection logic receives the memory transaction receives the indication from the comparison logic, allows the memory write transaction to proceed in response to the indication indicating that the memory address is not included in the memory address range, and drops the memory write transaction in response to the indication indicating that the memory address is included in the memory address range.

Abstract: A flow monitoring system is described for monitoring flow of a mixed-phase sample comprising at least a first phase and a second phase having different electrical conductivities, the second phase being a liquid or a gas and substantially electrically non- conductive and the first phase being a liquid and having a conductivity higher than the second phase.

Abstract: Tomography apparatus comprises: a plurality of electrodes arranged around a perimeter of a cross section of a sample volume for containing a liquid or mixed-phase sample, each electrode being arranged to be in electrical contact with a sample contained in the sample volume; measurement means adapted to perform a set of measurements, each measurement comprising driving a current between a first respective adjacent pair of said electrodes and measuring a voltage developed across a second respective adjacent pair of said electrodes; and processing means adapted to generate a tomogram indicative of sample conductivity over said cross section from said set of measurements. The processing means is arranged to calculate sample conductivity values of a portion of said cross section from said set of measurements and generate said tomogram from said calculated sample conductivity values of said portion using an assumption of symmetry.

Abstract: A memory protection module includes comparison logic that has a write-once window CSR that stores a memory address range, and window protection logic. The comparison logic receives a memory write transaction, determines a memory address of the memory write transaction, and provides an indication as to whether or not the memory address is included in the memory address range. The window protection logic receives the memory transaction, receives the indication from the comparison logic, allows the memory write transaction to proceed in response to the indication indicating that the memory address is not included in the memory address range, and drops the memory write transaction in response to the indication indicating that the memory address is included in the memory address range.

Abstract: A memory protection module includes comparison logic that has a write-once window CSR that stores a memory address range, and window protection logic. The comparison logic receives a memory write transaction, determines a memory address of the memory write transaction, and provides an indication as to whether or not the memory address is included in the memory address range. The window protection logic receives the memory transaction, receives the indication from the comparison logic, allows the memory write transaction to proceed in response to the indication indicating that the memory address is not included in the memory address range, and drops the memory write transaction in response to the indication indicating that the memory address is included in the memory address range.