Abstract: The present disclosure is directed to novel bispecific Fc fusion proteins with an IF-15 domain, an Interleukin-15 receptor alpha (IF-15R?) sushi domain, an Fc domain and a soluble PD-1 (sPD-1) variant domain, polynucleotides encoding said bispecific Fc fusion proteins, methods of making and using thereof.

Abstract: A driving circuit, a driving module, a driving method, a display substrate and a display device are provided. The driving circuit includes a first leakage prevention circuit, an output circuit and a first control node control circuit; the first leakage prevention circuit is configured to control to connect or disconnect the first control node, the first node and the first intermediate node under the control of a first voltage signal provided by the first voltage line according to a potential of the first intermediate node, control to connect or disconnect the first intermediate node and the second voltage line under the control of the potential of the first node, and control to disconnect the first control node and the first node when the first intermediate node and the second voltage line is connected.

Abstract: Provided is a pixel drive circuit. The pixel drive circuit includes a plurality of scan drive circuits transmitting gate drive signals to pixels, a plurality of emission drive circuits transmitting emission control signals to the pixels, a plurality of compensation drive circuits transmitting compensation signals to the pixels, and a plurality of reset drive circuits transmitting reset signals to the pixels, which are all cascaded in a pixel column direction. In addition, the scan drive circuit, the emission drive circuit, the compensation drive circuit, and the reset drive circuit corresponding to the same row of pixels are arranged sequentially along a pixel row direction, the scan drive circuit being disposed farthest away from the pixels. Moreover, among signal lines coupled to the pixel drive circuit, a plurality of signal lines is overlapped with each other, and cutouts are provided at the overlapping portions of the plurality of signal lines.

Abstract: Turbinmicin analogs of Formula I are provided. Compositions including Turbinmicin analogs of Formula I, such as pharmaceutical compositions including effective amounts of Turbinmicin analogs of Formula I for treating fungal infections such as Candida and Aspergillus, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with Turbinmicin analogs of Formula I and compositions thereof are disclosed.

Abstract: A driving method and an apparatus, and a storage medium are provided. The driving method is applied to a pixel drive circuit, the pixel drive circuit including a drive transistor, the drive transistor including a second electrode and a third electrode; and the method includes: applying a data voltage acquired based on a reference gamma curve to the third electrode of the drive transistor, and applying a preset voltage to the second electrode of the drive transistor; a lowest voltage of the reference gamma curve is greater than a lowest voltage of a standard gamma curve, and the preset voltage is less than or equal to the lowest voltage of the reference gamma curve.

Abstract: Provided is a display panel including: a substrate, including a display region and a GOA region at least partially surrounding the display region; a plurality of pixels arranged in arrays, disposed in the display region; a first GOA circuit, disposed in the GOA region, wherein the first GOA circuit includes a plurality of cascaded first GOA units, each of the first GOA units being coupled to at least one row of the pixels and being configured to transmit a gate drive signal to the at least one row of the pixels; and a second GOA circuit, disposed in the GOA region, wherein the second GOA circuit includes a plurality of cascaded second GOA units, each of the second GOA units being coupled to at least one row of the pixels and being configured to transmit a light emission control signal to the at least one row of the pixels.

Abstract: An array substrate is provided. The array substrate includes a plurality of data lines; a plurality of second fanout connecting lines; and a plurality of first voltage supply lines. In at least one subpixel of the array substrate, an individual data line of the plurality of data lines and an individual second fanout connecting line of the plurality of second fanout connecting lines have a substantial mirror symmetry with respect to an individual first voltage supply fine of the plurality of first voltage supply lines.

Abstract: A spiking neuron reinforcing circuit and a spiking neuron reinforcing method are provided.

Abstract: Provided is a method for sensing pixel internal data in a display device. The method includes: sensing pixel internal data for each line of pixel units to determine column sequence numbers of suspected abnormal pixel units in the line of pixel units; determining, based on a number of the suspected abnormal pixel units of each column sequence number in the at least three lines of pixel units, whether a sensing signal line corresponding to the column sequence number is an abnormal sensing signal line; and in a case that there is at least one abnormal sensing signal line, replacing pixel internal data of a column of pixel units corresponding to each abnormal sensing signal line with pixel internal data of at least one column of pixel units adjacent to the abnormal sensing signal line each time the pixel internal data of all pixel units is sensed.

Abstract: A display substrate is provided to include: a base substrate including a display area and a peripheral area surrounding the display area; pixel units in array are in the display area; a driving module is in the peripheral area and is configured to provide electrical signals for the pixel units, to control the pixel units to operate; the driving module includes driving circuits each provided with a corresponding operating signal line group in the peripheral area; the signal line group includes at least two operating signal lines connected to the corresponding driving circuit, to provide electrical signals thereto; the at least two operating signal lines include first and second clock signal lines; the first clock signal lines for at least two driving circuits are a same first clock signal line; and/or the second clock signal lines for the at least two driving circuits are a same second clock signal line.

Abstract: A pixel circuit includes a driving sub-circuit coupled to a first node, a second node and a third node, a compensation sub-circuit coupled to the first node, the third node and a first scan signal terminal, an adjustment sub-circuit, and a writing sub-circuit. The compensation sub-circuit includes a first transistor group, and the first transistor group includes at least two first transistors connected in series. A fourth node is formed between a second electrode of a first first transistor and a first electrode of a second first transistor. The adjustment sub-circuit is coupled to the fourth node and at least one control terminal. The adjustment sub-circuit is configured to, in light-emitting phases, adjust a voltage of the fourth node under a control of a signal from the at least one control terminal, so as to reduce a voltage difference between the fourth node and the first node.

Abstract: Turbinmicin, an isolated compound of Formula (I) or IA is provided. Turbinomycin compounds of Formula (II) or (IIA) are also provided. A compound isolated from a bacterial species from the sea squirt, Ecteinascidia turbinate, and having a chemical formula of C34H29NO11 is also provided. Compositions including turbinmicin and turbinmicin compounds, such as pharmaceutical compositions including effective amounts of turbinmicin or turbinomicing compounds for treating fungal infections such as Candida and Aspergillus, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with turbinmicin, turbinmicin compounds and compositions thereof are disclosed.

Abstract: A kitchen waste wastewater treatment equipment includes a reaction kettle, a discharging mechanism and a pressurizing mechanism. In the process of high-temperature and high-pressure thermal hydrolysis of wastewater in the present disclosure, the pressurizing disk in the pressurizing mechanism continuously moves downwards in a vacuum state in the reaction kettle, reducing the volume in the reaction kettle and thus increasing the pressure. The secondary pressurization of wastewater is achieved while using heating for high-temperature and high-pressure, and the high-temperature and high-pressure environment greatly improves the reaction rate of thermal hydrolysis. The thermal hydrolysis reaction also generates gas for further pressurization, which greatly improves the treatment efficiency of wastewater. Moreover, the pressurizing mechanism and the exhaust annular groove can separate the gas generated after thermal hydrolysis.

Abstract: The pixel circuit includes: a light emitting module configured to emit light; a driving module configured to drive the light emitting module to emit light according to a driving voltage during a light emitting stage; a storage module configured to maintain the driving voltage and to provide the driving voltage to the driving module during the light emitting stage; a first transistor, a first electrode of the first transistor being connected to a position where the driving module receives the driving voltage, and a second electrode of the first transistor being not directly connected to a signal source; a second transistor, a first electrode of the second transistor being connected to the first electrode of the first transistor, wherein a structure to which a second electrode of the second transistor is connected is different from a structure to which the second electrode of the first transistor is connected.

Abstract: A method and system for detecting nascent geographic atrophy. An optical coherence tomography (OCT) volume image of a retina of a subject is received. Using a deep learning model, an output is generated using the OCT volume image in which the output indicates whether nascent geographic atrophy is detected. A map output is generated for the deep learning model using a saliency mapping algorithm, wherein the map output indicates a level of contribution of a set of regions in the OCT volume image to the output generated by the deep learning model.

Abstract: An array substrate, a manufacturing method thereof, and a display panel are provided. The present invention uses an inkjet printing method to construct a two-dimensional nanomaterial as a photosensitive film, and adjusts a composition of the nanomaterial to construct a photoelectric film with high gain, which is then combined with a high mobility film to construct a display device with high mobility and broad spectrum light response.

Abstract: A flexible mechanism-based anti-backlash device for a planetary gear train, a gearbox, and a robot joint are provided. The anti-backlash device includes an integrated flexible planet carrier, an adjusting screw and a spring, the integrated flexible planet carrier is provided with a moving platform, the moving platform is provided with a spring hole, and the spring is sleeved outside the screw and is installed in the spring hole; when the threaded connection depth of the adjusting screw and the integrated flexible planet carrier reaches or exceeds a set depth, the adjusting screw can extrude the spring to make the moving platform generate elastic movement along a radial direction of the integrated flexible planet carrier, and the radial elastic movement is transformed into circumferential elastic rotation of a planet carrier bearing hole around the center of the planet carrier through an elastic connector.

Abstract: A display panel and a display device, relate to the technical field of display technology. The present disclosure disposes a plurality of subpixel on a substrate, each subpixel comprises a compensating transistor, a drive transistor, a storage capacitance and a first initialization signal line, a first active pattern of the compensating transistor includes a first active section, a second active section and a third active section, the second active section extends along a first direction, and extension directions of the first active section and the third active section intersect with the first direction; the first initialization signal line extends along the first direction, and an overlapping area exists between an orthogonal projection of the first initialization signal line on the substrate and an orthogonal projection of the second active section on the substrate, the first initialization signal line overlaps with the first active pattern directly to form a coupling capacitance.

Abstract: A display panel and a display device are provided, which belong to the field of display technologies. The display panel includes: a substrate including a display region and a gate driver on array (GOA) region, a plurality of rows and a plurality of columns of pixels disposed in the display region, and a first GOA circuit disposed in the GOA region. The first GOA circuit includes a plurality of cascaded first shift register units, and the plurality of first shift register units are coupled to the plurality of rows of pixels by a plurality of gate lines, and are configured to transmit gate drive signals to the plurality of rows of pixels through the plurality of gate lines, to drive the plurality of rows of pixels to emit light.