Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

Abstract: Aspects of methods, apparatuses, and computer-readable media for performing multi-material selection optimization (MMSO) to provide topologically and geometrically optimized multi-component structures (MCSs) across a plurality of design inputs and constraints are proposed. In some embodiments, a 3-D print model of an object based on load case criteria is obtained. A portion of the 3-D print model is determined that can be replaced with a commercial-off-the-shelf (COTS) part model such that the load case criteria remain satisfied. The portion or the 3-D print model can then be replaced with the COTS part model to determine the MCS model. In various embodiments, a mesh representation of the model can be generated, and plurality of optimization techniques can be used to determine the MCS model.

Abstract: One embodiment provides an apparatus comprising a memory stack including multiple memory dies and a parallel processor including a plurality of multiprocessors. Each multiprocessor has a single instruction, multiple thread (SIMT) architecture, the parallel processor coupled to the memory stack via one or more memory interfaces. At least one multiprocessor comprises a multiply-accumulate circuit to perform multiply-accumulate operations on matrix data in a stage of a neural network implementation to produce a result matrix comprising a plurality of matrix data elements at a first precision, precision tracking logic to evaluate metrics associated with the matrix data elements and indicate if an optimization is to be performed for representing data at a second stage of the neural network implementation, and a numerical transform unit to dynamically perform a numerical transform operation on the matrix data elements based on the indication to produce transformed matrix data elements at a second precision.

Abstract: A method of measuring one or more conditions within a predetermined area includes receiving at a control system a signal including scattered light and time of flight information associated with a plurality of nodes of a detection system, parsing the time of flight information into zones of the detection system, identifying one or more features within the scattered light signal, and analyzing the one or more features within the scattered light signal to determine a presence of the one or more conditions within the predetermined area.

Abstract: The invention relates to a method for screening a library of peptide ligands, said library comprising a plurality of polypeptides covalently linked to a molecular scaffold at two or more amino acid residues, comprising the steps of displaying said library of peptide ligands in a genetic display system, wherein the polypeptide comprises two or more reactive groups which form a covalent linkage to the molecular scaffold, and at least one loop which comprises a sequence of amino acids subtended between two of said reactive groups; exposing the peptide ligands to one or more cells which display one or more target molecules on the cell surface; and screening the peptide ligands for binding against the target, and selecting the ligands which bind to the target.

Abstract: The present disclosure relates to a filter housing having a bowl and a head. The bowl is configured to house a portion of a filter cartridge. The bowl has an annular groove disposed about a rim of the bowl. The head is configured to mate with the bowl. The head includes an inlet, outlet, and a pair of levers. The inlet is to receive a flow of fluid into the filter housing. The outlet is to release the flow of fluid from the filter housing. The pair of levers are to draw the bowl partially into the head. Each lever has a first arm configured to mate with the annular groove, a second arm having a bearing surface, and a pivot disposed between the first arm and the second arm. A force upon the bearing surface urges the bowl into the head to form a seal.

Abstract: An online concierge system iteratively makes a batch of one or more orders available to an increasing number of shoppers to choose to fulfill. Each shopper may choose to accept or reject a batch for fulfillment. To improve batch acceptance and matching between batches and shoppers, the batches are scored with respect to expected resource costs, likelihood of acceptance by the shopper, and/or other quality metrics to iteratively offer the batch to an increasing number of shoppers (prioritizing the scoring factors) until a shopper accepts. The number of shoppers notified of the batch and the frequency that additional shoppers are selected may vary based on characteristics of the batch and likelihood the batch will be accepted by a shopper.

Abstract: A head-mounted display (HMD) determines whether a set of criteria is satisfied based on eye-related readings collected by a camera of the HMD and wirelessly transmits a set of messages in response to a determination that the set of criteria is satisfied. An attachment includes a set of light-emitting diodes (LEDs) and activates the set of LEDs to emit the light at the bleaching intensity in response to receiving the set of messages.

Abstract: A method and apparatus for authenticating a user commerce account associated with a merchant of a commerce platform are described. The method may include initiating authentication of the user commerce account associated with the merchant of the commerce platform from a commerce platform user interface of a user device, the user commerce account established for a user of the merchant. The method may also include sending an electronic message to a mobile device associated with the user account at the commerce platform, wherein the electronic message comprises an authentication code, and receiving the authentication code from the commerce platform user interface. Furthermore, the method may include generating an authentication key for the mobile device in response to matching the received authentication code with the sent authentication code and receiving a cookie provided from the commerce platform to the mobile device.

Abstract: This disclosure relates to novel formulations of bis-choline tetrathiomolybdate useful for treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD). For example, this disclosure relates to low dose formulations of bis-choline tetrathiomolybdate.

Abstract: Provided are bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof, and methods for identifying such bivalent compounds.

Abstract: Provided are organometallic compounds comprising a carbazole group as the central moiety to which at least two further groups selected from carbazole and benzo[d]benzo[4,5]imidazo[1,2-a]imidazole are attached. Also provided are formulations comprising these organometallic compounds. Further provided are organic light emitting devices (OLEDs) and related consumer products that utilize these organometallic compounds.

Abstract: An optical proximity sensor includes a housing, an optical emitter, and an optical detector. A first light guide disposed in a first chimney of the housing is configured to direct light from the optical emitter through the first chimney towards a target location. A second light guide disposed in a second chimney of the housing is configured to direct a returned portion of the light emitted from the optical emitter through the second chimney towards the optical detector.

Abstract: The present disclosure is generally related to modified filamentous fungal strains (cells) comprising enhanced protein productivity phenotypes, wherein such modified strains are particularly well-suited for growth in submerged cultures (e.g., large-scale production of proteins for industrial/commercial applications). Thus, certain embodiments of the disclosure are related to such variant (modified) strains of filamentous fungus derived (obtained) from parental strains comprising a gene encoding a native GEF1 protein, wherein the variant strain comprises a genetic modification which disrupts or deletes a gene encoding a native GEF1 protein, wherein the variant strain comprises an increased protein productivity phenotype (i.e., relative to the parental strain) when grown/cultivated/fermented under the same conditions.

Abstract: The present disclosure describes oligonucleotide-tethered nucleotides, methods of making them, and methods of using them. The oligonucleotide-tethered nucleotides comprise, in some embodiments, a nucleotide linked to an oligonucleotide of from about 3 to about 100 nucleotides in length. These oligonucleotide-tethered nucleotides can be used to label a plurality of different types of nucleic acids in a plurality of different situations with a known oligonucleotide, which can serve as a barcode in some embodiments. The resulting oligonucleotide-labeled nucleic acids oligo-nucleotides can be used in a variety of nucleic acid sequencing methods.

Abstract: A filter device and methods of use thereof are provided. The filter device may include a pitcher for removably engaging with a base in fluid communication with a fluid source. The pitcher may include a magnetic float assembly, and the base may include a sensor, e.g., a Reed switch, for detecting when a magnetic float of the magnetic float assembly is within a detectable range of the sensor. Upon detection of the magnetic float within the detectable range by the sensor, a controller of the filter device may instruct a pump to pump fluid from the fluid source, through a filtration system of the filter device, and into the pitcher. When the pitcher is full of fluid, the magnetic float will be out of the detectable range of the sensor, such that fluid will stop being transferred from the fluid source to the pitcher.

Abstract: A method, system and computer-usable medium are disclosed for operating an endpoint agent at an endpoint device. Certain embodiments include a computer-implemented method for operating an endpoint agent at an endpoint device, including: operating the endpoint agent to selectively subscribe to events corresponding to activities occurring at an endpoint platform; processing events received from a message bus by the endpoint agent, where the events processed by the endpoint agent are events to which the endpoint agent has subscribed; and communicating, to a service, information corresponding to the events processed by the endpoint agent. Other embodiments of this aspect of the invention may include corresponding stand-alone and/or network computer systems, apparatus, and computer programs recorded on one or more computer storage devices, each configured to perform one or more of these actions.

Abstract: The selective dimerization of isoolefins, such as isobutene or isopentane, or mixtures thereof, may be conducted in a system including a series of fixed bed reactors and a catalytic distillation reactor. The system may provide for conveyance of the fixed bed reactor effluents, without componential separation, to a downstream reactor. It has been found that a high selectivity to the dimer may be achieved even though intermediate separation of the desired product from unreacted components between reactors is not performed. Further, embodiments provide for use of a divided wall column for recovery of a high purity dimer product, reducing unit piece count and plot size.

Abstract: A multi-fluid kit for three-dimensional printing can include a fusing agent with water and a radiation absorber, and a detailing agent. The radiation absorber can absorb radiation energy and converts the radiation energy to heat. The detailing agent can include water and from about 0.1 wt % to about 20 wt % organosilanes based on a total weight of the detailing agent, wherein the organosilanes include an organosilane compound with a central silicon having both a water-solubilizing group and multiple hydrolyzable groups attached thereto.

Abstract: A system and method for selecting leadwire stimulation parameters includes a processor iteratively performing, for each of a plurality of values for a particular stimulation parameter, each value corresponding to a respective current field: (a) shifting the current field longitudinally and/or rotationally to a respective plurality of locations about the leadwire; and (b) for each of the respective plurality of locations, obtaining clinical effect information regarding a respective stimulation of the patient tissue produced by the respective current field at the respective location; and displaying a graph plotting the clinical effect information against values for the particular stimulation parameter and locations about the leadwire, and/or based on the obtained clinical effect information, identifying an optimal combination of a selected value for the particular stimulation parameter and selected location about the leadwire at which to perform a stimulation using the selected value.