Patents by Inventor Michael A. Crowe

Michael A. Crowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Voxel build
    Patent number: 11941759
    Abstract: A computer-implemented method that allows users evaluate the densities of images and search for abnormalities in three-dimensional space. The voxel buildup uses a series of two-dimensional images and evaluates every pixel based on the user described predetermined threshold value at runtime. A singular optimized voxel-generated mesh is spawned to represent the combined locations of every pixel.
    Type: Grant
    Filed: February 21, 2022
    Date of Patent: March 26, 2024
    Assignee: Intuitive Research and Technology Corporation
    Inventors: Chanler Crowe, Michael Jones, Kyle Russell, Michael Yohe
  • CONTINUOUS TIME SIGNAL PROCESSING SYSTEMS AND SUBSYSTEMS
    Publication number: 20230412185
    Abstract: Continuous time pipeline, level-crossing (LC), analog-to-digital converters (ADCs) use a plurality of stages from a first stage to a last stage. Each stage has an array of comparators that are provided with an array of reference voltage levels. Each stage is configured to detect level crossings of increasing fineness compared to the preceding stage such that the accuracy of a digitized representation of an input signal can be increased by adding stages as well as increasing the number of comparators in each stage. The voltage error in the digitized representation of the signal that remains after each stage provides the input to the subsequent stage. The continuous time pipeline LC ADCs are also applied to analog signal processing and software defined radios.
    Type: Application
    Filed: March 31, 2023
    Publication date: December 21, 2023
    Inventors: Patrick W. Jungwirth, W. Michael Crowe
  • BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS
    Publication number: 20210348139
    Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.
    Type: Application
    Filed: July 19, 2021
    Publication date: November 11, 2021
    Inventors: Jovana Nazor, Derek J. Smith, Michael A. Crowe, Shiwei Song, Steven J. Collier
  • Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
    Patent number: 11098291
    Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: August 24, 2021
    Assignee: Codexis, Inc.
    Inventors: Jovana Nazor, Derek J. Smith, Michael A. Crowe, Shiwei Song, Steven J. Collier
  • Power Tool and Tool Accessory Data Connection
    Publication number: 20210245353
    Abstract: A power tool system includes a portable power tool having a housing, a motor with an output shaft in the housing, a tool holder secured on the output, and a data reader. The system also includes a power tool accessory configured to be retained by the tool holder that has a data storage device having data stored thereon. The data reader is configured to access the data stored on the data storage device when the power tool accessory is retained by the tool holder.
    Type: Application
    Filed: June 25, 2019
    Publication date: August 12, 2021
    Inventors: Christopher R. Crowell, Michael Crowe
  • BIOCATALYSTS FOR EZETIMIBE SYNTHESIS
    Publication number: 20210222134
    Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 22, 2021
    Inventors: Michael A. Crowe, Oscar Alvizo, Behnaz Behrouzian, Yong Koy Bong, Steven J. Collier, Anupam Gohel, Jagadeesh Mavinahalli, Naga K. Modukuru, Emily Mundorff, Derek J. Smith, Shiwei Song, Wan Lin Yeo
  • Biocatalysts for Ezetimibe synthesis
    Patent number: 10995320
    Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: May 4, 2021
    Assignee: Codexis, Inc.
    Inventors: Michael A. Crowe, Oscar Alvizo, Behnaz Behrouzian, Yong Koy Bong, Steven J. Collier, Anupam Gohel, Jagadeesh Mavinahalli, Naga K. Modukuru, Emily Mundorff, Derek J. Smith, Shiwei Song, Wan Lin Yeo
  • BIOCATALYSTS FOR EZETIMIBE SYNTHESIS
    Publication number: 20200123506
    Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: December 12, 2019
    Publication date: April 23, 2020
    Inventors: Michael A. Crowe, Oscar Alvizo, Behnaz Behrouzian, Yong Koy Bong, Steven J. Collier, Anupam Gohel, Jagadeesh Mavinahalli, Naga K. Modukuru, Emily Mundorff, Derek J. Smith, Shiwei Song, Wan Lin Yeo
  • BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS
    Publication number: 20200123512
    Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.
    Type: Application
    Filed: December 9, 2019
    Publication date: April 23, 2020
    Inventors: Jovana Nazor, Derek J. Smith, Michael A. Crowe, Shiwei Song, Steven J. Collier
  • Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
    Patent number: 10544402
    Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: January 28, 2020
    Assignee: Codexis Inc.
    Inventors: Jovana Nazor, Derek J. Smith, Michael A. Crowe, Shiwei Song, Steven J. Collier
  • Biocatalysts for ezetimibe synthesis
    Patent number: 10544400
    Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: January 28, 2020
    Assignee: Codexis, Inc.
    Inventors: Michael A. Crowe, Oscar Alvizo, Behnaz Behrouzian, Yong Koy Bong, Steven J. Collier, Anupam Gohel, Jagadeesh Mavinahalli, Naga K. Modukuru, Emily Mundorff, Derek J. Smith, Shiwei Song, Wan Lin Yeo
  • BIOCATALYSTS FOR EZETIMIBE SYNTHESIS
    Publication number: 20180312818
    Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: July 11, 2018
    Publication date: November 1, 2018
    Inventors: Michael A. Crowe, Oscar Alvizo, Behnaz Behrouzian, Yong Koy Bong, Steven J. Collier, Anupam Gohel, Jagadeesh Mavinahalli, Naga K. Modukuru, Emily Mundorff, Derek J. Smith, Shiwei Song, Wan Lin Yeo
  • Biocatalysts for Ezetimibe synthesis
    Patent number: 10053673
    Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: August 21, 2018
    Assignee: Codexis, Inc.
    Inventors: Michael A. Crowe, Oscar Alvizo, Behnaz Behrouzian, Yong Koy Bong, Steven J. Collier, Anupam Gohel, Jagadeesh Mavinahalli, Naga K. Modukuru, Emily Mundorff, Derek J. Smith, Shiwei Song, Wan Lin Yeo
  • BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS
    Publication number: 20170283781
    Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.
    Type: Application
    Filed: June 15, 2017
    Publication date: October 5, 2017
    Inventors: Jovana Nazor, Derek J. Smith, Michael A. Crowe, Shiwei Song, Steven J. Collier
  • Multiple location electronic device communication
    Patent number: 9739618
    Abstract: An in-vehicle control system for communicating data between at least one of an office control system and a residential control system including a transceiver configured to be in communication with the office control system and the residential control system. The in-vehicle control system further including a memory device in communication with the transceiver. The memory device is configured to store a data file transmitted and/or received from the office control system and the residential control system.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: August 22, 2017
    Assignee: Visteon Global Technologies, Inc.
    Inventors: Rodger W. Eich, Michael Crowe, John Sibson, William J. Fluharty
  • BIOCATALYSTS FOR EZETIMIBE SYNTHESIS
    Publication number: 20170204378
    Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: April 4, 2017
    Publication date: July 20, 2017
    Inventors: Michael A. Crowe, Oscar Alvizo, Behnaz Behrouzian, Yong Koy Bong, Steven J. Collier, Anupam Gohel, Jagadeesh Mavinahalli, Naga K. Modukuru, Emily Mundorff, Derek J. Smith, Shiwei Song, Wan Lin Yeo
  • Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
    Patent number: 9708588
    Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: July 18, 2017
    Assignee: Codexis, Inc.
    Inventors: Jovana Nazor, Derek J. Smith, Michael A. Crowe, Shiwei Song, Steven J. Collier
  • Biocatalysts for ezetimibe synthesis
    Patent number: 9644189
    Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: May 9, 2017
    Assignee: Codexis, Inc.
    Inventors: Michael A. Crowe, Oscar Alvizo, Behnaz Behrouzian, Yong Koy Bong, Steven J. Collier, Anupam Gohel, Jagadeesh Mavinahalli, Naga K. Modukuru, Emily Mundorff, Derek J. Smith, Shiwei Song, Wan Lin Yeo
  • Chemical process for preparing spiroindolones and intermediates thereof
    Patent number: 9598712
    Abstract: The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1?R,3?S)-5,7?-dichloro-6?-fluoro-3?-methyl-2?,3?,4?,9?-tetrahydrospiro[indoline-3,1?-pyrido[3,4-b]indol]-2-one and salts and hydrates and solvates thereof.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: March 21, 2017
    Assignee: Novartis AG
    Inventors: Michael Crowe, Michael Foulkes, Giancarlo Francese, Dominique Grimler, Ernst Kuesters, Kurt Laumen, Yunzhong Li, Changxue Lin, Jovana Nazor, Thomas Ruch, Derek Smith, Shiwei Song, Shangjun Teng
  • BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS
    Publication number: 20160289649
    Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.
    Type: Application
    Filed: June 13, 2016
    Publication date: October 6, 2016
    Inventors: Jovana Nazor, Derek J. Smith, Michael A. Crowe, Shiwei Song, Steven J. Collier