Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered polypeptides having transaminase activity, polynucleotides encoding the polypeptides, methods of the making the polypeptides, and methods of using the polypeptides for the biocatalytic conversion of ketone substrates to amine products. The present enzymes have been engineered to have one or more residue differences as compared to the amino acid sequence of the naturally occurring transaminase of Vibrio fluvialis. In particular, the transaminases of the present disclosure have been engineered for efficient formation of chiral tryptamine derivatives from its corresponding prochiral ketone substrates.

Abstract: A mobile electronic communications device includes a housing, a memory, a data entry mechanism, a display for visual data, at least one wireless transceiver configured to transmit and receive electromagnetic signals conforming to a plurality of wireless signaling protocols, and a controller. The controller is communicatively connected to the memory, data entry mechanism, and display; and is configured to send and receive data using the at least one wireless transceiver.

Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered polypeptides having transaminase activity, polynucleotides encoding the polypeptides, methods of the making the polypeptides, and methods of using the polypeptides for the biocatalytic conversion of ketone substrates to amine products. The present enzymes have been engineered to have one or more residue differences as compared to the amino acid sequence of the naturally occurring transaminase of Vibrio fluvialis. In particular, the transaminases of the present disclosure have been engineered for efficient formation of chiral tryptamine derivatives from its corresponding prochiral ketone substrates.

Abstract: The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1?R,3?S)-5,7?-dichloro-6?-fluoro-3?-methyl-2?,3?,4?,9?-tetrahydrospiro[indoline-3,1?-pyrido[3,4-b]indol]-2-one and salts and hydrates and solvates thereof.

Abstract: A mobile electronic communications device includes a housing, a memory, a data entry mechanism, a display for visual data, at least one wireless transceiver configured to transmit and receive electromagnetic signals conforming to a plurality of wireless signaling protocols, and a controller. The controller is communicatively connected to the memory, data entry mechanism, and display; and is configured to send and receive data using the at least one wireless transceiver.

Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Abstract: An in-vehicle control system for communicating data between at least one of an office control system and a residential control system including a transceiver configured to be in communication with the office control system and the residential control system. The in-vehicle control system further including a memory device in communication with the transceiver. The memory device is configured to store a data file transmitted and/or received from the office control system and the residential control system.

Abstract: A dynamic braking load analyzer that determines the proper resistance value for a dynamic braking load resistor to be used in combination with a variable frequency drive or servo-drive to accommodate the power dissipated from an induction motor when it is being reduced in speed. The analyzer includes a resistor bank having a plurality of resistors electrically coupled in parallel. Switches are provided between the resistors, and a resistor selector switch determines which resistors are switched into the resistor bank circuit. A heat sensing resistor in the resistor bank measures the heat generated by the resistors and provides a signal that is read by a heat meter. The combination of the temperature measurement and the resistance of the resistors in the circuit gives the proper braking resistance value for the deceleration of the induction motor.

Abstract: A tool for temporarily lifting and supporting reinforcing mesh above an underlying surface includes an elongate rod that can be held at a first end and which has a portion at a second end opposing the first end. The elongate rod, which can engage under an element of mesh, is mounted on a base member for turning on the underlying surface with a rotary movement of the elongate rod, so that movement of the elongate rod acts to lift the element of mesh.

Abstract: A dynamic braking load analyzer that determines the proper resistance value for a dynamic braking load resistor to be used in combination with a variable frequency drive or servo-drive to accommodate the power dissipated from an induction motor when it is being reduced in speed. The analyzer includes a resistor bank having a plurality of resistors electrically coupled in parallel. Switches are provided between the resistors, and a resistor selector switch determines which resistors are switched into the resistor bank circuit. A heat sensing resistor in the resistor bank measures the heat generated by the resistors and provides a signal that is read by a heat meter. The combination of the temperature measurement and the resistance of the resistors in the circuit gives the proper braking resistance value for the deceleration of the induction motor.

Abstract: A method and apparatus for stimulating a muscle of a subject are provided. The apparatus comprises a signal generator for generating an electrical pulse signal of a frequency and a current amplitude for inducing contractions in the muscle, and an electrode apparatus for applying the signal to nerves associated with the muscle to be stimulated or adjacent the muscle of the subject for stimulating the muscle. The frequency and current amplitude of the electrical pulse signal are selected so as to maximize the bulk of the muscle being subjected to the contractions so as to generate a shivering phenomenon therein.

Abstract: A device for attaching at least three electrodes to a subject for stimulating abdominal muscles of the subject, comprising an attachment mechanism for extending around the torso of the subject and a main locating element provided on the attachment mechanism for locating a central electrode of the at least three electrodes adjacent the umbilicus of the subject. Two secondary locating elements are also provided on the attachment mechanism disposed on respective opposite sides of the main locating element for locating two corresponding side electrodes of the at least three electrodes spaced apart from the central electrode. Application of at least one pulsed signal to the subject through the respective central and side electrodes stimulates the abdominal muscles of the subject.

Abstract: Pulsed electrical stimulation is applied to selected tissues via electrodes positioned on and/or in the body. Each electrode is connected to an output (108) of the apparatus. Each output (108) is connected between a high side switch (110) and a low side switch (112) of a switching array. Each stimulation pulse is subdivided into a number of time periods. By operation of the switches (110, 112) each electrode can be selected to operate as an anode or a cathode or neither during any given time period. The spatial and/or time summation of the anode-cathode currents is controlled to selectively to stimulate selected regions and/or types of tissues, typically nerve tissues.

Abstract: Pulsed electrical stimulation is applied to selected tissues via electrodes positioned on and/or in the body. Each electrode is connected to an output (108) of the apparatus. Each output (108) is connected between a high side switch (110) and a low side switch (112) of a switching array. Each stimulation pulse is subdivided into a number of time periods. By operation of the switches (110, 112) each electrode can be selected to operate as an anode or a cathode or neither during any given time period. The spatial and/or time summation of the anode-cathode currents is controlled to selectively to stimulate selected regions and/or types of tissues, typically nerve tissues.