Abstract: A combined artificial cell death/reporter system polypeptide containing a herpes simplex virus thymidine kinase (HSV-tk) fused to a prostate-specific membrane antigen (PSMA) polypeptide via a linker is described. Also described are polynucleotides encoding the artificial cell death polypeptide, cells expressing the artificial cell death polypeptide and related methods.

Abstract: Provided are methods for generating ?? T cells from induced pluripotent stem cells. Also provided are genetically engineered iPSCs, ?? T cells, CAR-?? T cells, and methods of using the same.

Abstract: A rotary roller motor is disclosed herein. The rotary roller motor is a four-stroke internal combustion engine, wherein the rotor “rolls” around the inside of the engine block. The rotor is a two-part rotor having an inner part with a shaft and an offset circular lobe, and an outer rotor fit around the lobe. Two barriers are provided around the rotor chamber, a compression/power barrier and an exhaust/intake barrier. The combustion chamber has a non-reversing compression barrier and a compression hold barrier regulating the combustion of gas.

Abstract: Methods of promoting healing of a wound in a dermal location of a subject are provided. Aspects of the methods may include administering an effective amount of a YAP inhibitor composition to the wound to modulate mechanical activation of Engrailed-1 lineage-negative fibroblasts (ENFs) in the wound to promote ENF-mediated healing of the wound. Also provided are methods of preventing scarring during healing of a wound in a subject and methods of promoting hair growth on a subject. Aspects of the methods may include forming a wound in a dermal location of a subject and administering an effective amount of a YAP inhibitor composition to the wound to modulate mechanical activation of Engrailed-1 lineage-negative fibroblasts (ENFs) in the wound to promote ENF-mediated healing of the wound. Also provided are kits including an amount of a YAP inhibitor composition and a tissue disrupting device.

Abstract: Various embodiments discussed herein enable client applications to be heavily integrated with a voice assistant in order to both perform commands associated with voice utterances of users via voice assistant functionality and also seamlessly cause client applications to automatically perform native functions as part of executing the voice utterance. For example, some embodiments can automatically and intelligently cause a switch to a page the user needs and automatically and intelligently cause a population of particular fields of the page the user needs based on a user view context and the voice utterance.

Abstract: Various embodiments discussed herein enable client applications to be heavily integrated with a voice assistant in order to perform commands associated with voice utterances of users via voice assistant functionality and also seamlessly cause client applications to automatically perform native functions as part of executing the voice utterance. Such heavy integration also allows particular embodiments to support multi-modal input from a user for a single conversational interaction. In this way, client application user interface interactions, such as clicks, touch gestures, or text inputs are executed alternative or in addition to the voice utterances.

Abstract: A method of making a component includes: depositing a metallic powder on a workplane; directing a beam from a directed energy source to fuse the powder in a pattern corresponding to a cross-sectional layer of the component; repeating in a cycle the steps of depositing and fusing to build up the component in a layer-by layer fashion; and during the cycle of depositing and melting, using an external heat control apparatus separate from the directed energy source to maintain a predetermined temperature profile of the component, such that the resulting component has a directionally-solidified or single-crystal microstructure.

Abstract: A system for remote sensing of air gaps includes a substrate and a capacitor sensor array attached to the substrate, where the capacitor sensor array includes a plurality of capacitor sensors. The system also includes a transmit antenna attached to the substrate, and a microprocessor electrically connected to the transmit antenna and the capacitor sensor array. The microprocessor is configured to switch on and off at least one capacitor sensor of the plurality of capacitor sensors and to transmit determined air gap measurements using the transmit antenna.

Abstract: A method for planarizing a metal conductor layer embedded in a dielectric layer is provided. The method includes removing a portion of an overburden of the metal conductor layer that is formed over the dielectric layer with a first CMP slurry. The method also includes removing a remaining portion of the overburden of the metal conductor layer with a second CMP slurry to expose upper portions of the dielectric layer.

Abstract: A method of providing blockchain wireless services in a controlled environment is provided. The method comprises a wireless communication device associated with an inmate of a controlled environment receiving one of a voice and video call from a device external to the controlled environment. The method further comprises the device placing the received call into a hold state and sending a request for validation of the call via a blockchain, the request identifying at least parties to the call. The method further comprises the device, upon receipt of validation, removing the call from the hold state; and enabling at least one of voice and video functionality for the parties. The method further comprises the wireless communication device sending the request for validation to a telecommunications server and the server conducting real time monitoring of the call. The method further comprises the device continuously recording the call.

Abstract: Methods and systems for detecting when users deviate from a provided transportation route and for correcting the transportation route in response to such user deviations is presented. In one embodiment, a method is provided including detecting a changed condition for a transportation route between a first location and a second location. The transportation route may include multiple transportation segments. A first transportation segment designating a first modality may be identified, wherein the changed condition decreases a likelihood that vehicles associated with the first modality will be available to service the first transportation segment. In response, a second transportation segment designating a second modality different from the first modality is generated. The first transportation segment is then replaced with the second transportation segment in the transportation route.

Abstract: A technique for controlling access to one or more attractions is achieved using a number of access keys, each being issued to one or more users. An electronic queue management part manages a virtual queue in respect of each attraction and receives electronic requests for attraction access, each request relating to an access key and being for the users associated with it to access a particular attraction. Receipt of each request causes the respective users to be added to a corresponding virtual queue. A time at which each group of users reaches the front of the virtual queue and can access the attraction is determined. The users access the attractions by presenting an access key to an access control part, in communication with the electronic queue management part. Only a user presenting an access key at the correct time for accessing the attraction is allowed access to the attraction.

Abstract: Embodiments herein provide for improved range response in lidar systems. In one embodiment, a lidar system includes a laser, and a detector. First optics direct light from the laser on a beam path along a first optical axis of the first optics. Second optics image the light from the beam path onto a second plane that is substantially normal to the first plane. The second optics have a second optical axis that differs from the first optical axis. The first and the second optical axes lie in a same first plane. A first line in the first plane intersects a second line in the second plane at an acute angle. The first line is perpendicular to the first optical axis. A spatial filter configured in or near the second plane filters the light from the second optics onto the detector.

Abstract: Methods and systems for planning and creating transportation routes with multiple modalities are provided. In one embodiment, a method is provided that includes receiving a transportation request that includes a first location and a second location. A transportation proposal may then be generated including a route for transportation between the first location and the second location. The method may then include determining modalities available to provide transportation and determining respective transportation segments for the modalities, and at least a subset of the transportation segments may be combined to form the route for transportation. The transportation proposal, including the route for transportation, may then be transmitted for display on a mobile device.

Abstract: A high-temperature, high-strength, oxidation-resistant cobalt-nickel base alloy is disclosed. The alloy includes, in weight percent: about 3.5 to about 4.9% of Al, about 12.2 to about 16.0% of W, about 24.5 to about 32.0% Ni, about 6.5% to about 10.0% Cr, about 5.9% to about 11.0% Ta, and the balance Co and incidental impurities. A method of making an article having high-temperature strength, cyclic oxidation resistance and corrosion resistance is disclosed. The method includes forming a high-temperature, high-strength, oxidation-resistant cobalt-nickel base alloy as described herein; forming an article from the alloy; solution-treating the alloy by a solution heat treatment; and aging the alloy by providing at least one aging heat treatment at an aging temperature that is less than the gamma-prime solvus temperature, wherein the alloy is configured to form a continuous, protective, adherent oxide layer on an alloy surface upon exposure to a high-temperature oxidizing environment.

Abstract: The present disclosure provides chimeric antigen receptors (CARs), particularly CARs that have adaptable receptor specificity (arCARs). Also provided are polypeptides of the CARs and other related molecules, polynucleotides, vectors, and cell compositions comprising the same. Pharmaceutical compositions comprising the polypeptides, polynucleotides, vectors, or cells of the present disclosure, and their uses in treating a disease in a subject are also provided.

Abstract: An exemplary notification device has a frame to securely attach it to a standing structure. The exemplary notification device also has a display coupled to the frame with at least one section displaying one of an activity or a period of time. The notification device has a processor electrically connected to the display and configured to make at least one real-time visible update to the at least one section of the display after the period of time elapses. The processor also delivers information related to the at least one update to a location external of the notification device.

Abstract: A system for repairing a glenoid defect of a specific patient can include a patient-specific punch and a patient-specific shaping block. The patient-specific punch can form a patient-specific glenoid implant from a bone puck. The patient-specific shaping block can shape the patient-specific glenoid implant to match and fill a glenoid defect of a specific patient.

Abstract: A hair length mapping or cutting device uses multiple comb elements to capture bunches of hair as it is traversed across a scalp. The comb elements are traversed away from the scalp to individually measure or cut each bunch of hair to length. Hair may be cut to conform to a hair style mapped, for instance, from an earlier measurement of a hair style.

Abstract: Methods are provided to separately isolate antigen-binding T cells and antigen-activated T cells derived from a starting population of peripheral blood mononuclear cells, and to identify overlapping T cell receptor clonotypes. Antigens include personal and shared neoantigens as well as cancer-testis antigens. The T cell receptor clonotypes can be further used to develop cancer treatment therapies.