Abstract: An ergonomic and unobtrusive cardiac monitoring and treatment device for continuous wear includes a band configured to be worn about a thoracic region of a patient within a T1 thoracic vertebra region to a T12 thoracic vertebra region. The band includes a vertical span of between 1 to 15 centimeters along at least 50 percent of a length of the band and is configured to be immobilized relative to a skin surface of the thoracic region by exerting one or more compression forces. The device also includes electrodes and associated circuitry disposed about the band, one or more sensor ports for receiving one or more physiological sensors separate from ECG sensing electrodes, and a controller. The controller includes an ingress-protected housing and a processor configured to analyze ECG information of the patient, detect one or more treatable arrhythmias based on the ECG information, and cause delivery of electrotherapy.

Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R4 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.

Abstract: A flexible lighting strip for use in an aircraft cabin has a minimum bend radius of no more than 40 mm, and comprises: a track comprising a channel extending along the length of the track; and an inner component within the channel, the inner component comprising lighting components arranged along the length of the inner component. The track comprises two inwardly-directed protrusions extending from opposing sides of the channel, each of the protrusions extending into the inner component 4 and increasing in width within the inner component. The inner component may be formed separately as an insertable insert, or may be formed within the track. A kit of parts for forming such a flexible lighting strip is also disclosed.

Abstract: Systems and methods for sorting and imaging insects, including egg and larval life stages, useful for automated high throughput bioassays.

Abstract: The present embodiments of the invention generally relate to methods for sorting and imaging insects, including egg and larval life stages, useful for automated high throughput bioassays.

Abstract: Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of neuroblastoma, small cell lung cancer (SCLC), large cell neuroendocrine cancer (LCNEC), large-cell carcinoma (LCC), squamous cell carcinoma (SqCC), and/or adenocarcinoma (AC) in subjects in need thereof. The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of neuroblastoma, small cell lung cancer (SCLC), large cell neuroendocrine cancer (LCNEC), large-cell carcinoma (LCC), squamous cell carcinoma (SqCC), and/or adenocarcinoma (AC) in the subject.

Abstract: The present invention provides a ground engaging film roller 30.2 having a generally horizontal axis of rotation and an outer circumference for engaging ground, the roller having opposed outer ends 30.21 of a larger circumference than the circumference of portions 30.22 located between the opposed ends. The present invention also provides a film deployment system having a ground engaging film roller as described above, which is rotationally mounted to a frame 30.1, the ground engaging film roller 30.2 receiving film from above and to a front location of the roller, and passing between a film locating roller 30.3 and the ground engaging roller 30.2, the ground engaging roller 30.2 shaping the ground it engages by forming a channel in ground at the opposed ends 30.21 of the roller 30.2 for the film to be located as it leaves engagement with the ground engaging roller 30.2.

Abstract: The present invention provides a ground engaging film roller 30.2 having a generally horizontal axis of rotation and an outer circumference for engaging ground, the roller having opposed outer ends 30.21 of a larger circumference than the circumference of portions 30.22 located between the opposed ends. The present invention also provides a film deployment system having a ground engaging film roller as described above, which is rotationally mounted to a frame 30.1, the ground engaging film roller 30.2 receiving film from above and to a front location of the roller, and passing between a film locating roller 30.3 and the ground engaging roller 30.2, the ground engaging roller 30.2 shaping the ground it engages by forming a channel in ground at the opposed ends 30.21 of the roller 30.2 for the film to be located as it leaves engagement with the ground engaging roller 30.2.

Abstract: A frozen topologically modified dough product is produced by creating topological features in a dough piece having a main body portion including an upper surface and a lower surface, wherein the topological features is at least one of undulations in the upper surface created through formation of a series of crest and trough regions and a series of tunnels created in the main body portion of the dough piece, and then freezing the dough piece to produce a frozen dough piece. When cooked, particularly through a convection baking operation, the topological features increase the surface area for convection heat transfer during the baking operation, resulting in a significantly reduced overall bake time.

Abstract: An apparatus for support of exercise activities includes a frame having a first Y-shaped portion adjoining a second Y-shaped portion. The two Y-shaped portions share a common leg having opposing ends. Each of the Y-shaped portions has two outboard ends. A support member is coupled to each of the opposing ends of the common leg, each of the two outboard ends of the first Y-shaped portion, and each of the two outboard ends of the second Y-shaped portion. Each such support member is adapted to fit through a hole in a weight plate and adapted to have an exercise resistance band coupled thereto.

Abstract: The present invention is directed to all aspects of novel methyl transferase enzymes that methylate backbone amides of (poly)peptides. The present invention also relates to nucleic acids encoding these enzymes as well as corresponding vectors and host cells comprising these. Moreover, the present invention encompasses the use of said enzymes for modifying (poly)peptides as well as corresponding methods. Also, the present invention pertains to further novel enzymes for modifying (poly)peptides derived from the omphalotin gene cluster of O. olearius and the homologous gene clusters from D. bispora, L. edodes and F. mediterranea as well as related aspects.

Abstract: The invention provides various methods for classifying prostate cancers into subtypes. The classification methods may be used to diagnose or prognose prostate cancers. In one embodiment, the subtypes are PCS1, PCS2, or PCS3. In one embodiment, the PCS1 subtype is most likely to progress to metastatic disease or prostate cancer specific mortality when compared to the PCS2 subtype or PCS3 subtype. In one embodiment, the PCS1 subtype is resistant to enzalutamide.

Abstract: The invention is for a sanitary container to receive and at least temporarily store waste. The container has a hollow housing with an upper aperture, and a portion of the housing can open and reveal the hollow interior. There is an upper part, located substantially above the housing to act as a lid, and this can move to open and close the upper aperture. There is an endless cassette non-rotationally mounted at or near the upper aperture, which holds a length of shirred plastics tubing which exits the cassette at or near its top and which can flow down through a central aperture of the endless cassette toward a bottom of the housing to form a containment. The containment can then receive waste from the upper aperture when open by the lid. The containment can be accessed by the portion when open, and the containment can be drawn downwardly to form a new containment replenished from the cassette and sealed closed by the sealer unit, and allows removal of the containment.

Abstract: Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof. The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.

Abstract: An apparatus for support of exercise activities includes a frame having a first Y-shaped portion adjoining a second Y-shaped portion. The two Y-shaped portions share a common leg having opposing ends. Each of the Y-shaped portions has two outboard ends. A support member is coupled to each of the opposing ends of the common leg, each of the two outboard ends of the first Y-shaped portion, and each of the two outboard ends of the second Y-shaped portion. Each such support member is adapted to fit through a hole in a weight plate and adapted to have an exercise resistance band coupled thereto.

Abstract: Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof. The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.

Abstract: A core form device including a circular plate and a plurality of bendable arms extending from the circular plate which when bent about the circular plate form the core form device.

Abstract: Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of neuroblastoma, small cell lung cancer (SCLC), large cell neuroendocrine cancer (LCNEC), large-cell carcinoma (LCC), squamous cell carcinoma (SqCC), and/or adenocarcinoma (AC) in subjects in need thereof. The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of neuroblastoma, small cell lung cancer (SCLC), large cell neuroendocrine cancer (LCNEC), large-cell carcinoma (LCC), squamous cell carcinoma (SqCC), and/or adenocarcinoma (AC) in the subject.

Abstract: The present invention provides a ground engaging film roller 30.2 having a generally horizontal axis of rotation and an outer circumference for engaging ground, the roller having opposed outer ends 30.21 of a larger circumference than the circumference of portions 30.22 located between the opposed ends. The present invention also provides a film deployment system having a ground engaging film roller as described above, which is rotationally mounted to a frame 30.1, the ground engaging film roller 30.2 receiving film from above and to a front location of the roller, and passing between a film locating roller 30.3 and the ground engaging roller 30.2, the ground engaging roller 30.2 shaping the ground it engages by forming a channel in ground at the opposed ends 30.21 of the roller 30.2 for the film to be located as it leaves engagement with the ground engaging roller 30.2.

Abstract: Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.