Abstract: The present invention is directed to all aspects of novel methyl transferase enzymes that methylate backbone amides of (poly)peptides. The present invention also relates to nucleic acids encoding these enzymes as well as corresponding vectors and host cells comprising these. Moreover, the present invention encompasses the use of said enzymes for modifying (poly)peptides as well as corresponding methods. Also, the present invention pertains to further novel enzymes for modifying (poly)peptides derived from the omphalotin gene cluster of O. olearius and the homologous gene clusters from D. bispora, L. edodes and F. mediterranea as well as related aspects.

Abstract: A method for measuring particle size distribution in a fluid material, involving inserting a laser beam instrument directly in the fluid flow line, wherein the laser beam instrument focuses a laser beam on a window directly coupled with the fluid flow line, wherein the fluid flow line comprises a fluid having a plurality of particles of different sizes, measuring a diameter of at least one particle in the fluid flow line by reflectance of the at least one particle as the at least one particle passes through the focused laser beam, and determining a duration of reflection of the at least one particle, and obtaining a count of particles in each of a pre-set range group of particle sizes, wherein the count of particles is used to determine particle size distribution in the fluid flow line.

Abstract: The invention provides various methods for classifying prostate cancers into subtypes. The classification methods may be used to diagnose or prognose prostate cancers. In one embodiment, the subtypes are PCS1, PCS2, or PCS3. In one embodiment, the PCS1 subtype is most likely to progress to metastatic disease or prostate cancer specific mortality when compared to the PCS2 subtype or PCS3 subtype. In one embodiment, the PCS1 subtype is resistant to enzalutamide.

Abstract: A core form device including a circular plate and a plurality of bendable arms extending from the circular plate which when bent about the circular plate form the core form device.

Abstract: A core form device including a circular plate and a plurality of bendable arms extending from the circular plate which when bent about the circular plate form the core form device.

Abstract: Systems, methods, and apparatus to facilitate the production and presentation of strokes gained golf statistics. Some systems include mobile devices for the collection of essential shot data necessary for producing strokes gained statistics during play. The device travels with a golfer, measures and records distance-to-hole automatically using GPS and/or laser and/or radio technology, in combination with one of various lie-type classifications (tee, fairway, rough, sand, green, recovery, penalty, hazards, etc.) before and after a golf shot as selected by the golfer using human judgement. The device transfers essential shot data to a remote database and receives and displays calculated strokes gained results.

Abstract: A method of blasting rock at an underground blast site in which boreholes (11a, b, c) are drilled in a rock mass 10 from a drive defining face 12, each borehole is loaded with at least one charge of explosive material (13a-c, 14a-c, 15a-c), at least one detonator is placed in operative association with each charge, and a sequence of at least two initiation events is conducted to blast the rock mass, in each of which only some of the charges are initiated, by sending firing signals to only the detonators associated with said charges and in which each initiation event is a discrete user-controlled initiation event. In one of the at least two initiation events a stranded portion of the rock mass such as a pillar is created that has already been drilled and charged, and the stranded portion of the rock mass is blasted in a subsequent one or more of the at least two initiation events without personnel accessing said stranded portion.

Abstract: A core form device including a circular plate and a plurality of bendable arms extending from the circular plate which when bent about the circular plate form the core form device.

Abstract: A method of blasting rock at an underground blast site in which boreholes (11a, b, c) are drilled in a rock mass 10 from a drive defining face 12, each borehole is loaded with at least one charge of explosive material (13a-c, 14a-c, 15a-c), at least one detonator is placed in operative association with each charge, and a sequence of at least two initiation events is conducted to blast the rock mass, in each of which only some of the charges are initiated, by sending firing signals to only the detonators associated with said charges and in which each initiation event is a discrete user-controlled initiation event. In one of the at least two initiation events a stranded portion of the rock mass such as a pillar is created that has already been drilled and charged, and the stranded portion of the rock mass is blasted in a subsequent one or more of the at least two initiation events without personnel accessing said stranded portion.

Abstract: A disrupter unit is used for explosive ordnance disposal by firing a slug into the ordnance to be destroyed. A method is shown to secure the disrupter unit to a sand bag or other stationary location during such firing of the disrupter unit. The present invention may also adapt the disrupter unit to shear wire, such as barbed wire, by attaching a wire cutter element to the disrupter unit through a robust cable during firing. Likewise, the disrupter unit may be used as a remote pull device or further to unearth a buried item via mechanical advantage, wherein a military shovel or another long rod is attached by a robust cable to the disrupter unit.

Abstract: The invention is for a sanitary container to receive and at least temporarily store waste. The container has a hollow housing with an upper aperture, and a portion of the housing can open and reveal the hollow interior. There is an upper part, located substantially above the housing to act as a lid, and this can move to open and close the upper aperture. There is an endless cassette non-rotationally mounted at or near the upper aperture, which holds a length of shirred plastics tubing which exits the cassette at or near its top and which can flow down through a central aperture of the endless cassette toward a bottom of the housing to form a containment. The containment can then receive waste from the upper aperture when open by the lid. The containment can be accessed by the portion when open, and the containment can be drawn downwardly to form a new containment replenished from the cassette and sealed closed by the sealer unit, and allows removal of the containment.

Abstract: A method of blasting rock at an underground blast site in which boreholes (11a, b, c) are drilled in a rock mass (10) from a drive defining face (12), each borehole is loaded with at least one charge of explosive material (13a-c, 14a-c, 15a-c), at least one detonator is placed in operative association with each charge, and a sequence of at least two initiation events is conducted to blast the rock mass, in each of which only some of the charges are initiated, by sending firing signals to only the detonators associated with said charges and in which each initiation event is a discrete user-controlled initiation event. In one of the at least two initiation events a stranded portion of the rock mass such as a pillar is created that has already been drilled and charged, and the stranded portion of the rock mass is blasted in a subsequent one or more of the at least two initiation events without personnel accessing said stranded portion.

Abstract: A method for measuring particle size distribution in a fluid material, involving inserting a laser beam instrument directly in the fluid flow line, wherein the laser beam instrument focuses a laser beam on a window directly coupled with the fluid flow line, wherein the fluid flow line comprises a fluid having a plurality of particles of different sizes, measuring a diameter of at least one particle in the fluid flow line by reflectance of the at least one particle as the at least one particle passes through the focused laser beam, and determining a duration of reflection of the at least one particle, and obtaining a count of particles in each of a pre-set range group of particle sizes, wherein the count of particles is used to determine particle size distribution in the fluid flow line.

Abstract: A down hole tool including a compression surface, a compression surface axis, and at least one support member configured to attach the compression surface to a well drilling tool assembly, wherein the extendable support member is extendable by an extension force provided to the support member. The down hole tool is rotable relative to an axis of the well drilling tool assembly, and as the well drilling tool assembly rotates, the at least one compression device exerts a lateral force along a sidewall of a wellbore. Also, a method of forming filter cake comprising releasing a drilling fluid and contacting the drilling fluid with a mechanical pressure on the sidewall of the wellbore and the drilling fluid.

Abstract: Systems, methods, and apparatus for facilitating the production and presentation of strokes gained golf statistics are described. Some systems include the use of mobile devices for the collection of data during play. The device travels with a golfer and has the means to measure distance-to-hole automatically using GPS and/or laser technology. The device has the means to record shot data before and after a golf shot. The shot data includes the distance-to-hole and lie type of a ball at rest. Lie type is determined by human judgment. The device has the means to transfer data to a database. Some systems may include a database to compile data from mobile devices. The database is arranged to allow for strokes gained analysis of the data, which may be used to generate strokes gained statistics, presented on a computer output system. Related methods also are described.

Abstract: A method includes determining particle size distribution (PSD) in a fluid flow line based on a range of sizes for at least one particle in the fluid flow line and duration of reflection of a laser beam from the at least one particle. The laser beam is focused from a laser beam instrument in direct contact with the fluid low line.

Abstract: A photoacoustic detector wherein control circuits compensate for long term variations of components therein including a light source and sensing microphones. The control circuits intermittently energize the source to evaluate changes in at least source resistance. The control circuits intermittently energize an acoustic generator to evaluate changes in one or more generator responsive microphones.