Abstract: Examples of the present disclosure describe systems and methods relating to adaptive virtual services. In an example, a user specifies a device configuration for a platform device. As a result, a service provider installs selected virtual-network functions and defines network connections as specified by the device configuration. Management software may also be installed, thereby enabling the service provider to communicate with and remotely manage the platform device. The installed virtual-network functions are activated on the platform device once it is delivered to the user. In some instances, the user changes the device configuration. For example, the user may install new virtual-network functions, reconfigure or remove existing virtual-network functions, or change defined network connections. As a result, the service provider reconfigures the platform device accordingly. Thus, the user need not purchase new specialized hardware in order to change the available functions of the computer network.

Abstract: A patient interface for delivering breathable gas to a patient includes a nasal prong assembly including a pair of nasal prongs structured to sealingly communicate with nasal passages of a patient's nose in use and headgear to maintain the nasal prong assembly in a desired position on the patient's face. The headgear includes side straps and rigidizers provided to respective side straps. Each rigidizer includes a first end portion that provides a connector structured to engage a respective end of the nasal prong assembly and an inwardly curved protrusion in the form of a cheek support that curves inwardly of the connector. The cheek support is adapted to follow the contour of the patient's cheek and guide a respective end portion of the side strap into engagement with the patient's cheek to provide a stable cheek support.

Abstract: Embodiments of the present disclosure are drawn to systems and methods for adjusting a three-dimensional (3D) model used in metal additive manufacturing to maintain dimensional accuracy and repeatability of a fabricated 3D part. These embodiments may be used to reduce or remove geometric distortions in the fabricated 3D part. One exemplary method may include: receiving, via one or more processors, a selection made by a user; receiving a 3D model of a desired part; retrieving at least one model constant based on the user's selection; receiving an input of at least one process variable setting from a set of process variable settings; generating transformation factors based on the at least one process variable parameter and the at least one model constant; transforming the 3D model of the desired part based on the transformation factors; and generating processing instructions for fabricating the transformed 3D model of the desired part.

Abstract: A trained ML algorithm may be configured to process medical imaging data to generate a prediction of at least one diagnosis of a patient based on the medical imaging data. The prediction of the at least one diagnosis of the patient is compared with a validated label of the at least one diagnosis of the patient and the performance of the trained ML algorithm is determined based on the comparison. The validated label of the at least one diagnosis of the patient is obtained by parsing a validated radiology report of the patient and the medical imaging data is associated with the validated radiology report. If the performance of the trained ML algorithm is lower than a threshold, an update of parameters of the trained ML algorithm may be triggered based on the validated label.

Abstract: Methods, systems, and media for object grouping and manipulation in immersive environments are provided. In some embodiments, a method can include: displaying a plurality of virtual objects in an immersive environment; generating a group virtual object that includes a first virtual object and a second virtual object, the group virtual object including a handle interface element for interacting with the group virtual object and a selectable indicator associated with the first virtual object and the second virtual object; displaying the group virtual object along with the handle interface element and the selectable indicator in the immersive environment; and in response to detecting a selection of the selectable indicator, displaying a user interface for interacting with the group virtual object.

Abstract: Example embodiments of the present disclosure provide for an example method for controlling the activity of a production facility, such as a production facility having one or more automation environments. The example method includes receiving data indicative of a current production environment. The data can include data of a sensor representing a time since last unit or fill level at one or more processing stations in a production facility. The example method can include determining an impact probability of a downtime event based at least in part on data indicative of the current production environment. The example method can include determining the impact probability of a downtime event and performing a control action associated with the production facility in response to determining the impact probability of the downtime event.

Abstract: A patient interface for delivering breathable gas to a patient includes a nasal prong assembly including a pair of nasal prongs structured to sealingly communicate with nasal passages of a patient's nose in use and headgear to maintain the nasal prong assembly in a desired position on the patient's face. The headgear includes side straps and rigidizers provided to respective side straps. Each rigidizer includes a first end portion that provides a connector structured to engage a respective end of the nasal prong assembly and an inwardly curved protrusion in the form of a cheek support that curves inwardly of the connector. The cheek support is adapted to follow the contour of the patient's cheek and guide a respective end portion of the side strap into engagement with the patient's cheek to provide a stable cheek support.

Abstract: Examples of the present disclosure describe systems and methods relating to adaptive virtual services. In an example, a user specifies a device configuration for a platform device. As a result, a service provider installs selected virtual-network functions and defines network connections as specified by the device configuration. Management software may also be installed, thereby enabling the service provider to communicate with and remotely manage the platform device. The installed virtual-network functions are activated on the platform device once it is delivered to the user. In some instances, the user changes the device configuration. For example, the user may install new virtual-network functions, reconfigure or remove existing virtual-network functions, or change defined network connections. As a result, the service provider reconfigures the platform device accordingly. Thus, the user need not purchase new specialized hardware in order to change the available functions of the computer network.

Abstract: Assemblies fabricated by additive manufacturing include an object and a base plate providing support to the object during the manufacturing process. The geometry of the base plate is defined to optimize space and material constraints. During sintering, the base plate is reduced in area in a manner complementing the reduction in the footprint of the object, preserving the fidelity of the finished object.

Abstract: A computer implemented method of identifying anomalous behavior of a computer system in a set of intercommunicating computer systems, each computer system in the set being uniquely identifiable, the method including monitoring communication between computer systems in the set for a predetermined baseline time period to generate a baseline vector representation of each of the systems; monitoring communication between computer systems in the set for a subsequent predetermined time period to generate a subsequent vector representation of each of the systems; comparing baseline and subsequent vector representations corresponding to a target computer system using a vector similarity function to identify anomalous behavior of the target system in the subsequent time period compared to the baseline time period, wherein a vector representation of the target system for a time period is generated based on a deterministic walk of a graph representation of communications between the computer systems in which nodes of the

Abstract: Support substrates are used in certain additive fabrication processes to permit processing of an object. For additive fabrication processes with materials that are sintered into a final part, a multi-layer support substrate of interleaved support and interface layers is fabricated to support an object while reducing an impact of friction on shrinkage of the part during the sintering process.

Abstract: Provided herein are compositions and methods for treating succinic semialdehyde dehydrogenase deficiency (SSADHD). Compositions may include a gene encoding a functional succinic semialdehyde dehydrogenase (SSADH) enzyme, such as ALDH5A1, operably linked to a targeting vector. The functional SSADII enzyme is envisioned to lower the levels of circulating gamma-hydroxybutyric acid (GHB) and ?-aminobutyric acid (GABA). In some embodiments, combination therapies are envisioned, comprising administering to the subject therapeutically effective amounts of a combination of a composition comprising a gene encoding a functional SSADII enzyme operably linked to a targeting vector; one or more mTOR inhibitors; and a GABA-T inhibitor. Suitable mTOR inhibitors include rapamycin, while suitable GABA-T inhibitors include vigabatrin.

Abstract: Complexity of a geometry of a desired (i.e., target) three-dimensional (3D) object being produced by an additive manufacturing system, as well as atypical behavior of the processes employed by such a system, pose challenges for producing a final version of the desired 3D object with fidelity relative to the desired object. An example embodiment enables such challenges to be overcome as a function of feedback to enable the final version to be produced with fidelity. The feedback may be at least one value that is associated with at least one characteristic of a printed object following processing of the printed object. Such feedback may be obtained as part of a calibration process of the 3D printing system or as part of an operational process of the 3D printing system.

Abstract: A hydraulic radial piston device includes a housing, a pintle having a pintle shaft, a rotor mounted on the pintle shaft and defining a plurality of cylinders, and a plurality of pistons displaceable in the cylinders. The radial piston device further includes a piston ring that provides an interface for the pistons. The radial piston device includes various configurations for improving the performance and efficiency of the device.

Abstract: A 3D printer includes a build plate providing a surface on which an object is printed. Prior to printing, a sheet is fixed to the surface of the build plate. The sheet is composed of a material that adheres to a binder component of the feedstock used to print the object. During printing, the first layer of the printed object forms a bond with the sheet, which secures the location of the first layer and resists movement of the object during printing. Following printing and the object gaining sufficient rigidity, the object and sheet can be removed together from the printer. The sheet may then be peeled from the object, and the object can undergo debinding and/or sintering to create a finished object.

Abstract: 3D-printed parts may include binding agents to be removed following an additive manufacturing process. A debinding process removes the binding agents by immersing the part in a solvent bath causing chemical dissolution of the binding agents. The time of exposure of the 3D-printed part to the solvent is determined based on the geometry of the part, wherein the geometry is applied to predict the diffusion of the solvent through the 3D-printed part. The 3D-printed part is then immersed in the solvent bath to remove the binding agent, and is removed from the solvent bath after the time of exposure.

Abstract: Embodiments described herein relate to methods and systems for controlling the packing behavior of powders for additive manufacturing applications. In some embodiments, a method for additive manufacturing includes adding a packing modifier to a base powder to form a build material. The build material may be spread to form a layer across a powder bed, and the build material may be selectively joined along a two-dimensional pattern associated with the layer. The steps of spreading a layer of build material and selectively joining the build material in the layer may be repeated to form a three-dimensional object. The packing modifier may be selected to enhance one or more powder packing and/or powder flow characteristics of the base powder to provide for improved uniformity of the additive manufacturing process, promote sintering, and/or to enhance the properties of the manufactured three-dimensional objects.

Abstract: A method of metal additive manufacturing, including forming a three-dimensional object as a successive series of layers. At least some of the successive layers is formed by depositing a layer of build material powder on a work surface, depositing a predetermined pattern of fugitive fluid and depositing a predetermined pattern of binder fluid, wherein the predetermined pattern of fugitive fluid improves at least one characteristic of the three-dimensional part.

Abstract: Examples of the present disclosure describe systems and methods relating to adaptive virtual services. In an example, a user specifies a device configuration for a platform device. As a result, a service provider installs selected virtual-network functions and defines network connections as specified by the device configuration. Management software may also be installed, thereby enabling the service provider to communicate with and remotely manage the platform device. The installed virtual-network functions are activated on the platform device once it is delivered to the user. In some instances, the user changes the device configuration. For example, the user may install new virtual-network functions, reconfigure or remove existing virtual-network functions, or change defined network connections. As a result, the service provider reconfigures the platform device accordingly. Thus, the user need not purchase new specialized hardware in order to change the available functions of the computer network.