Abstract: A composite includes a first substrate and a second substrate joined in a bonding region, wherein the first substrate comprises a first Peak Force Tensile Strength and the second Peak Force Tensile Strength. The first Peak Force Tensile Strength is greater than or equal to the second Peak Force Tensile Strength. The bonding region has a Bond Density of about 10% to about 22%; and a Composite Tensile Strength at Peak Force that is within about 15% of the second Peak Force Tensile Strength.

Abstract: Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.

Abstract: Systems and methods for modular adjustable prosthetic volume compensation are disclosed herein. In one embodiment, a system for adjusting fit of a prosthetic device includes: a pump having a bleed actuator, a plunger and a pressure bulb. The system also includes a bladder fluidically coupled to the pump. The bladder lines a posterior section of an interior of a prosthetic device. A volume of the bladder is changeable by a pumping action of the pump. The volume of the bladder at least partially determines a space available inside the prosthetic device. The bleed actuator is configured to decrease a volume of the bladder. The plunger in operation squeezes the pressure bulb of the pump.

Abstract: Disclosed herein is computer technology that applies natural language processing (NLP) techniques to training data to generate information used to train a natural language generation (NLG) system to produce output that stylistically resembles the training data. In this fashion, the NLG system can be readily trained with training data supplied by a user so that the NLG system is adapted to produce output that stylistically resembles such training data. In an example, an NLP system detects a plurality of linguistic features in the training data. These detected linguistic features are then aggregated into a specification data structure that is arranged for training the NLG system to produce natural language output that stylistically resembles the training data. Parameters in the specification data structure can be linked to objects in an ontology used by the NLG system to facilitate the training of the NLG system based on the detected linguistic features.

Abstract: A method including executing a logical computing element (LCE) on a server. Worker LCEs are executed on the server. A first electronic file comprising geometry data in a first data structure is received at the controller LCE. An available worker LCE is identified, by the controller LCE, as an in-use worker LCE from among the worker LCEs. The geometry data is imported by the in-use worker LCE. A job instance is established by the in-use worker LCE. A rendering engine is launched by the in-use worker LCE. The rendering engine generates, for the job instance and using the geometry data, a dataset file in a second data structure different than the first data structure. The dataset file is returned by the in-use worker LCE to the controller LCE. The dataset file is returned by the controller LCE to a remote computer.

Abstract: Chromogenic compositions and devices are described herein which, in some embodiments, permit facile and environmentally friendly production while exhibiting efficient and reversible electrochromic activity. In some embodiments, a composite composition comprises one or more chromogenic thiazolothiazoles contained in an aqueous-based polyelectrolyte matrix. The one or more chromogenic thiazolothiazoles can be soluble in the aqueous-based polyelectrolyte matrix, in some embodiments. Moreover, the chromogenic thiazolothiazoles can comprise at least two pyridinium moieties. In some embodiments, the chromogenic thiazolothiazoles undergo a first color change in response to a first electron reduction, and a second color change in response to a second electron reduction.

Abstract: Logic may receive one or more questions from a customer in a chat. The logic may associate the one or more questions with one or more categories of subjects. The logic may store indications of the one or more categories of the subjects with a customer profile. The logic may select questions for a quiz for the customer based on the one or more categories of the subjects in the customer profile from a set of questions. The logic may present the one or more questions to the customer. And, in some embodiments, the logic may receive answers to the one or more questions from the customer.

Abstract: The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: A computer-implemented method comprising receiving captured sensor data; detecting, based on the captured sensor data, a person proximate a point of sale terminal; determining a category for the detected person proximate the point of sale terminal; and selectively providing access to functionality at the point of sale terminal based on the determined category of the detected person.

Abstract: A liquid concentrate generation system may comprise a manifold having an inlet receptacle including a first piercing member, an outlet receptacle including a second piercing member, and a flow channel connecting the inlet receptacle and outlet receptacle. The system may further comprise a cartridge having an inlet port and an outlet port sealed by a respective first and second cover. The inlet and outlet port may be respectively configured to displace within the inlet receptacle and outlet receptacle from an unspiked position to a spiked position. First and second piercing members may be in communication with the flow channel and spaced apart respectively from the first and second cover in the unspiked position. The first and second piercing members may be isolated from the flow channel and may respectively puncture the first and second cover in the spiked position.

Abstract: The present disclosure provides compositions and methods of using gene therapy to decrease cell migration and metastasis and reduce tumor mass or burden. The methods disclosed herein employ plasmids, vectors, and non-viral vectors that contain PCBP1 and/or PCBP1 mutants which inhibit the expression of cancer biomarkers and decrease cell migration or tumor size.

Abstract: A multi-stage process for transforming a high sulfur ISO 8217 compliant Feedstock Heavy Marine Fuel Oil involving a core desulfurizing process that produces a Product Heavy Marine Fuel Oil that can be used as a feedstock for subsequent refinery process such as anode grade coking, needle coking and fluid catalytic cracking. The Product Heavy Marine Fuel Oil exhibits multiple properties desirable as a feedstock for those processes including a sulfur level has a maximum sulfur content (ISO 14596 or ISO 8754) between the range of 0.05 mass % to 1.0 mass. A process plant for conducting the process is also disclosed.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: The present disclosure is directed to a coated metal substrate comprising a metal substrate; a coating applied over at least a portion of the metal substrate, wherein the coating comprises a film-forming binder; magnesium oxide; and an aluminum compound and/or iron compound; wherein the coating has a dry film thickness of at least 10 microns, and the magnesium oxide and the aluminum and/or iron compound are present in a weight ratio of 1:1 to 240:1. The present disclosure is also directed to a curable film film-forming coating composition a film-forming binder; magnesium oxide; and an aluminum compound and/or iron compound, wherein the magnesium oxide and the aluminum and/or iron compound are present in a weight ratio of 1:1 to 240:1. Also disclosed are methods of coating a substrate.

Abstract: A method of modifying a CAD system model performed on a data processing system includes receiving a dataset of co-ordinates representing an article in 2d, or in 3d and receiving 2d or 3d constraints respectively, to be applied to any changes to the dataset of co-ordinates for the article. A modification to be applied to the dataset is received and combined with the relevant 2d and 3d constraints to produce a constrained modification for each of the article and associated article. The constrained modification is solved in 2d and in 3d to determine whether a solution exists in which all constraints are met. If the solve is successful, the constrained modification is applied to each dataset simultaneously and, updated datasets are stored. If the solve fails, the constraints may be reduced and the solve step repeated, or the process is terminated.

Abstract: A helmet is provided that can include a cage defining a front end, a back end opposite the front end, a first lateral end and a second lateral end opposite the first lateral end. The cage can include multiple longitudinal beams that extend between the back end of the cage and the front end of the cage; and a transverse beam that extends between the first lateral end of the cage and the second lateral end of the cage. The transverse beam can be anchored to the multiple longitudinal beams. The helmet can include a body that fully encapsulates the multiple longitudinal beams of the cage and that partially encapsulates the transverse beam. The body can define multiple vents. Each vent can be situated between two adjacent longitudinal beams. The transverse beam can extend through one of the multiple vents.

Abstract: A medical product includes a bladder, a filtration device, and a sterile product concentrate. The bladder has a perimeter seal and defining a sterile chamber. The filtration device includes a stem and a filter membrane disposed in line with the stem. The stem extends through the perimeter seal and has an inlet end accessible from outside of the perimeter seal and an outlet end in fluid communication with the sterile chamber. The filter membrane can have a nominal pore size in a range of approximately 0.1 ?m to approximately 0.5 ?m, wherein the filter membrane is shaped as a hollow fiber with a wall and pores residing in the wall of the fiber. The sterile product concentrate is disposed in the sterile chamber and adapted to be reconstituted by the introduction of a pharmaceutical fluid into the chamber through the filtration device.

Abstract: An applet may be downloaded or provided to a web browser when a user visits a site in order to protect data input by the user from being captured by malicious software, such as key loggers. The applet may present a user input field in the web browser and may generate a random sequence of low-level key stroke or mouse click events within the input field when the user enters information, such as a username and/or password. A listening key logger will receive a large amount of random data, whereas the applet will receive and buffer the actual user data that may be communicated to a remote site access by the user.

Abstract: The present application discloses cellulose ester compositions that are plasticizer free that can be processed at higher temperatures with reduced degradation. The cellulose ester compositions disclosed are useful for the preparation of articles, for example eyeglass frames, automotive parts, and toys.