Abstract: A computer system includes a processor core and a memory system in signal communication with the processor core. The memory system includes a first cache and a second cache. The first cache is arranged at a first level of a hierarchy in the memory system and is configured to store a plurality of first-cache entries. The second cache is arranged at a second level of the hierarchy that is lower than the first level, and stores a plurality of second-cache entries. The first cache maintains a directory that contains information for each of the first-cache entries. The second cache maintains a shadow pointer directory (SPD) that includes one or more SPD entries that maps each of the first-cache entries to a corresponding second cache entry at a lower-level cache location.

Abstract: A container having a base and a lid is provided. The lid may be rotatable about a hinge from a closed configuration to an open configuration and may be secured, via one or more latching assemblies. The latching assembly may comprise a latch body, a locking member, a biasing member, and an activating member. Additional features of the container may include handles and strength increasing features. The base and lid may also feature attachment points for various accessories. A carry strap may attach to the base of the container to allow a user to lift and carry the container. The container may also have a wheels attached to the bottom portion and/or across the bottom portion to one side of the sidewall structure. In addition, in exemplary containers with wheels, a pull handle may be attached to a side opposite the wheels. The lid may include a lid support member that can act as a molle board to releasably secure items to the lid support member while also providing structural support to the lid.

Abstract: Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

Abstract: In one aspect, a system includes a movable barrier operator configured to open and close a movable barrier; at least one ultra-wideband device associated with the movable barrier operator and electrically configured to receive ultra-wideband radio frequency signals; and a processor operatively connected to the at least one ultra-wideband device and configured to use the ultra-wideband radio signals to determine a status of the movable barrier.

Abstract: Apparatus, methods, and computer-readable media for facilitating distribution matching via reversed compression are disclosed herein. An example method for wireless communication at a wireless transmitter includes decompressing a first sequence of information bits for wireless transmission to output a sequence of shaped symbols. The example method also includes compressing the sequence of shaped symbols to output a second sequence of compressed information bits. The example method also includes transmitting, to a receiver, a signal comprising the sequence of shaped symbols.

Abstract: A medical device, comprising a catheter comprising an end-effector, wherein the end-effector further comprises a proximal portion; and a flexible distal portion, wherein the distal portion further includes a window formed therein; and a flexible ultrasonic waveguide disposed within the end-effector, wherein the waveguide includes an active zone that extends through the window; and a mechanism for bending the waveguide, bending the distal portion, or bending both the waveguide and the distal portion, wherein the mechanism permits desired positioning of the waveguide within a lumen.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: A control system and methods for controlling the position of one or more engine-mounting links of an engine-mounting linkage system are provided. In one aspect, an engine-mounting linkage system includes one or more engine-mounting links that each have an adjustable inclination angle. An inclination angle of a link may be adjusted by an actuator of the control system. One or more controllers of the control system can control the actuator and thus the inclination angle of the link by determining a control command based at least in part on an output received from one or more sensors of the control system. The controllers can then cause the actuator to change the inclination angle of the link based at least in part on the determined control command.

Abstract: A detection system detects malfunctions in an autonomous farming vehicle during an autonomous routine using one or more models and data from sensors coupled to the autonomous farming vehicle. The models may include machine-learned models trained on the sensor data and configured to identify objects indicative of an operational or malfunctioning component within a tilling assembly such as a tilling shank or sweep. Additionally, a machine-learned model may be trained on sensor data to detect whether debris has plugged the tilling assembly of the autonomous farming vehicle. In response to detecting a malfunction or a plug, the detection system may modify the autonomous routine (e.g., pausing operation) or provide information for the malfunction to be addressed (e.g., the likely location of a malfunctioning sweep that has detached from the tilling assembly).

Abstract: Provided herein are molecules having an antigen binding fragment that immunospecifically binds to BTN1A1, such as anti-BTN1A1 antibodies. These molecules include those having an antigen binding fragment that immunospecifically binds to glycosylated BTN1A1, such as anti-glycosylated BTN1A1 antibodies. Methods of making and using these molecules are also provided, including methods of using them in cancer therapies, or as cancer diagnostics.

Abstract: In general, devices and systems for a tangentially actuated magnetic momentum transfer generator, and methods of use thereof, are provided. In an aspect, an electrical generator having a plurality of turns of wire forming a coil, a rotating magnet positioned in the coil, at least one stationary magnet positioned about the coil, and a slider movable relative to the rotating magnet in a direction tangential to an outer surface of the rotating magnet are provided. The slider can be configured to cause rotation of the rotating magnet, and the rotation of the rotating magnet and/or an interaction of the rotating magnet with a magnetic field of one or more of the at least one stationary magnet and the slider magnet can induce a voltage across a first terminal end and a second terminal end.

Abstract: The techniques herein are directed generally to a “zero-knowledge” data management network. Users are able to share verifiable proof of data and/or identity information, and businesses are able to request, consume, and act on the data—all without a data storage server or those businesses ever seeing or having access to the raw sensitive information (where server-stored data is viewable only by the intended recipients, which may even be selected after storage). In one embodiment, source data is encrypted with a source encryption key (e.g., source public key), with a rekeying key being an encrypting combination of a source decryption key (e.g., source private key) and a recipient's public key. Without being able to decrypt the data, the storage server can use the rekeying key to re-encrypt the source data with the recipient's public key, to then be decrypted only by the corresponding recipient using its private key, accordingly.

Abstract: Filaments that contain a filament-forming material and an additive, nonwoven webs, and methods for making such filaments are provided.

Abstract: The present invention is directed to a device having at least one port and at least three lumens, wherein the lumens are for visualization, irrigation and vacuuming. The device allows for vacuuming of debris from a subject, for example renal fragments, stones and dust up to at least 1 mm in size.

Abstract: A vehicle closure module overtravel accommodating system includes a closure module of a vehicle. The closure module is pivotably coupled to a vehicle frame and is configured to pivot relative to the vehicle frame back-and-forth between a closed position and an open position. The system further includes a breakaway mount of the vehicle, and a bumper assembly having a head disposed on a base. The bumper assembly engages the breakaway mount to secure the bumper assembly within the vehicle.

Abstract: A method to form the travel policy for an organization can include using feedback from a user selecting travel reservations annotated with the travel policy to continuously modify the travel policy. The travel policy can be improved to provide the organization with a control of the travel expenditures, together with an advanced knowledge of the travel reservations of the users. In addition, the travel policy can give the users the freedom to select the travel reservations that are most suitable to the users and also acceptable by the corporation.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Reanalysis of the SIMPLIFY 1 and 2 trials data indicates MMB is effective in JAKi-naïve patients and in second line therapy to RUX, providing benefits of reducing enlarged spleens, improving myelofibrosis-related symptoms, and increasing transfusion independence in patient at risk for thrombocytopenia from the underlying disease and RUX therapy. Accordingly, methods of treating myeloproliferative neoplasms (MPN) such as myelofibrosis are described. The methods can include administering a therapeutically effective amount of momelotinib or a pharmaceutically acceptable salt thereof to a subject identified as having (i) myelofibrosis and (ii) a platelet count of less than 150×109/L.